Am J Transplant, Volume 5, Suppl 3 Archives - Page 108 of 170 - ATC Abstracts

2015 American Transplant Congress
Notch Signaling Mediates Epithelial-to-Mesenchymal Transition in the Development of Marginal Liver Graft Fibrosis
X. Liu, K. Man, K. Ng, C. Lo.
Depatment of Surgery, The University of Hong Kong, Hong Kong, China.
Background and aims:Although graft size and chronic liver diseases have been proposed as risk factors for post-transplantation liver fibrosis, the underlying mechanisms remained unclear. Our…
2015 American Transplant Congress
Steroid Free Immunosuppression Protocol in Pediatric Kidney Transplant Recipients Using Alemtuzumab: A Retrospective Single Center Study
R. Shah,¹ Z. Kadry,¹ S. Wassner,² D. Kees-Folts,² M. Freeman,² P. Freeman,¹ B. Olenowski,¹ A. Jain.¹
¹Surgery, Hershey Medical Center, Hershey, PA; ²Pediatric Nephrology, Hershey Medical Center, Hershey, PA.
Background: Steroid free immunosuppression is attractive in pediatric kidney transplantation (KTx). Aim of the present study is to examine the patient survival, graft survival, rate…
2015 American Transplant Congress
Allograft Class II MHC and CD40 Expression Are Required for Endogenous Memory CD8 T Cell Proliferation in Cardiac Allografts Subjected to Prolonged Cold Ischemic Storage
T. Tanaka,^1,2 H. Tsuda,^1,3 N. Kohei,^1,4 D. Kish,¹ W. Baldwin,¹ A. Valujskikh,¹ R. Fairchild.¹
¹Immunology, Cleveland Clinic, Cleveland, OH; ²Urology, Sapporo Medical University, Sapporo, Japan; ³Urology, Osaka University, Osaka, Japan; ⁴Urology, Kidney Center, Tokyo Women's Medical University, Tokyo, Japan.
Endogenous memory CD8 T cells infiltrate MHC-mismatched cardiac allografts and produce IFN-γ in response to donor class І MHC within 24 hrs after graft reperfusion…
2015 American Transplant Congress
Assessment of Circulating HLA-Specific Alloreactive Memory B Cells Reveals Surreptitious Immunized Kidney Transplant Recipients at High Risk of Antibody-Mediated Rejection
M. Lúcia,¹ S. Luque,¹ E. Crespo,¹ J. Cruzado,^1,2 E. Melilli,² J. Martorell,³ J. Torras,^1,2 S. Gil-Vernet,² J. Grinyo,^1,2 O. Bestard.^1,2
¹Renal transplant Unit, Nephrology Department, Bellvitge University Hospital, Barcelona, Catalunya, Spain; ²Experimental Nephrology Laboratory, IDIBELL, Barcelona, Catalunya, Spain; ³Histocompatibility Unit, Immunology Department, Hospital Clinic, Barcelona, Catalunya, Spain.
Even though current bead-based multiplex techniques enable an accurate assessment of circulating HLA-specific antibodies, a more comprehensive study of the humoral alloimmune response through the…
2015 American Transplant Congress
Predicting Graft Loss in a Population of Kidney Transplant Patients Diagnosed With ABMR/TG
J. Reeve,¹ P. Halloran.¹
¹Laboratory Medicine and Pathology, University of Alberta, Edmonton, AB, Canada; ²Medicine, University of Alberta, Edmonton, AB, Canada.
ABMR is the main cause of late graft loss in kidney transplants. Our goal was to determine the variables most strongly predictive of graft loss…
2015 American Transplant Congress
Long-Term Excellent Results of ABO-Incompatible Kidney Transplantations at Multicenter Japanese Case Series
K. Tanabe,^１ H. Ishida,^１ K. Masutani,² Y. Okabe,³ M. Okumi,¹ H. Kitada,² T. Shimizu,⁴ H. Shirakawa.⁵
¹Urology, Tokyo Women's Medical University, Shinjuku, Tokyo, Japan; ²Kyushu University, Fukuoka, Japan; ³Surgery, Harasanshin Hospital, Fukuoka, Japan; ⁴Urology, Todachuo General Hospital, Toda, Saitama, Japan; ⁵Urology, Ohkubo Hospital, Shinjuku, Tokyo, Japan.
[Background]Although kidney transplantation (KT) is the most reassuring treatment for patients with ESRD, shortage of organ donation in Japan is crucial. This issue has forced…
2015 American Transplant Congress
Deceased Donor Kidney Transplantation Without Calcineurin Inhibitors or Steroids
A. Kirk,^1,2 A. Guasch,¹ S. Mead,¹ A. Ghali,¹ A. Mehta,¹ H. Gebel,¹ R. Bray,¹ C. Larsen,¹ T. Pearson.¹
¹Transplant Center, Emory University, Atlanta, GA; ²Surgery, Duke University, Durham, NC.
Kidney transplantation remains limited by toxicities of calcineurin inhibitors (CNIs) and steroids. Belatacept is a less toxic CNI alternative delivered by monthly intravenous infusion, but…
2015 American Transplant Congress
Induction Therapy (IT) in Simultaneous Pancreas and Kidney Transplantation (SPK) according to Patient Risk – A Registry Analysis
R. Gruessner,¹ A. Gruessner.²
¹Department of Surgery, University of Arizona, Tucson, AZ; ²College of Public Health, University of Arizona, Tucson, AZ.
Purpose: Optimal IT in SPK recipients (rec) according to patient risk has not been studied.Methods: Using the International Pancreas Transplant Registry database, we analyzed IT…
2015 American Transplant Congress
IL-2/IL-2 Ab Complex Leads to Long-Term Tolerance in a Treg Dependent DST Model of Skin Allograft Transplantation in Which DST and Timing of the Antibody Complex Are Crucial
G. Zhang,¹ Y. Wang,¹ M. Hu,¹ A. Sawyer,¹ J. Zhou,¹ S. Grey,² S. Alexander.¹
¹Children's Hospital at Westmead, Sydney, Australia; ²Garvan Institute, Sydney, Australia.
Background: In vivo Treg expansion using IL2 complexed with anti-IL2 antibody has been demonstrated to be effective in the induction of long-term acceptance of islet…
2015 American Transplant Congress
Cyclosporine Nephrotoxicity Is Associated With Diminished Expression of Heat Shock Protein 27 (HSP27) and Loss of Claudin-2-Dependent Intercellular Adhesion
A. Zmijewska,¹ R. Thuillier,² J. Chen,¹ J. Zmijewski,¹ R. Mannon.¹
¹Medicine, University of Alabama at Birmingham, Birmingham, AL; ²INSERM U1082, Poitiers, France.
Although Cyclosporine A (CsA), a calcineurin inhibitor (CNI), is an effective immunosuppressant used to prevent kidney allograft rejection, prolonged administration is frequently associated with kidney…