Am J Transplant, Volume 5, Suppl 3 Archives - Page 106 of 170 - ATC Abstracts

2015 American Transplant Congress
Human Bone Marrow Mesenchymal Stem Cell-Derived Hepatocytes Express TIMP-4 and Follistatin
J. Li,¹ J. Xin,¹ W. Ding,² S. Hao,¹ L. Jiang,¹ Q. Zhou,¹ T. Wu,¹ D. Shi,¹ L. Li.¹
¹State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, HangZhou, China; ²Systems Biology Division, Zhejiang-California International Nanosystems Institute, Zhejiang University, HangZhou, China.
Human bone marrow mesenchymal stem cell (hBMSC) transplantation has been expected to be an alternative regenerative technique for liver diseases. However, the mechanism by which…
2015 American Transplant Congress
Oxidative Stress During Organ Recovery Influences Transplant Vasculopathy Development
M. Maglione,¹ G. Riede,¹ B. Cardini,¹ D. Bernhard,² B. Messner,² K. Watschinger,³ C. Steger,⁴ G. Brandacher,⁵ J. Pratschke,¹ E. Werner,³ R. Oberhuber.¹
¹Department of Visceral, Transplant and Thoracic Surgery, Innsbruck Medical University, Innsbruck, Austria; ²Cardiac Surgery Research Laboratory, Department of Surgery, Vienna Medical University, Vienna, Austria; ³Division of Biological Chemistry, Biocenter, Innsbruck Medical University, Innsbruck, Austria; ⁴Institute of Pathology, Innsbruck Medical University, Innsbruck, Austria; ⁵Department of Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore, MD.
Transplant vasculopathy is still a major obstacle to long-term graft survival. Pharmacological strategies aiming at preventing it are still lacking. Herein we show that the…
2015 American Transplant Congress
The Influence of Immunosuppressive Drugs On the Epithelial Microenvironment in Solid Organ Transplantation – Identification of Biomarker Candidates for Rejection Vs. Tolerance
A. Akhdar,¹ B. Mueller,² C. Neudoerfl,¹ F. Lehner,³ M. Stevanovic-Meyer,¹ K. Daemen,¹ J. Keil,¹ H. Haller,⁴ C. Blume,^4,5 C. Falk.^1,6
¹Institute of Transplant Immunology, IFB-Tx, Hanover Medical School, Hanover, Germany; ²MorphoSys, Munich, Germany; ³Department of General, Visceral and Transplantation Surgery, Hanover Medical School, Hanover, Germany; ⁴Department of Nephrology and Hypertension, Hanover Medical School, Hanover, Germany; ⁵Institute of Technical Chemistry, Leibniz University Hanover, Hanover, Germany; ⁶German Center for Infection Research, Braunschweig, Germany.
In the context of kidney transplantation, NK cells may play an important role by targeting the allogeneic organ due to "missing-self recognition", which leads to…
2015 American Transplant Congress
Explorative Analysis of ZEUS After 5 Years: Histological Assessment from Biopsy Analyses
U. Eisenberger,¹ K. Budde,¹ O. Witzke,¹ F. Lehner,¹ C. Sommerer,¹ R. Wuethrich,³ P. Reinke,¹ A. Muehlfeld,¹ K. Heller,¹ R. Stahl,¹ H. Wolters,¹ I. Hauser,¹ M. Porstner,² W. Arns.¹
¹ZEUS Study Group, Germany; ²Novartis, Pharma, Germany; ³ZEUS Study Group, Switzerland.
Background: Analysis of pathologists' assessments and histological data allow for deeper insight on patient outcome together with investigator's final clinical diagnoses. Here we present 5…
2015 American Transplant Congress
Outcomes of Hispanic Kidney Transplant Recipients Under a Cyclosporine Versus Tacrolimus Based Immunosuppression Regimen
P. West-Thielke,¹ M. Campara,² A. Ladik,¹ E. Terranova,² E. Benedetti,¹ J. Thielke.²
¹Surgery, University of Illinois, Chicago; ²Pharmacy Practice, University of Illinois, Chicago.
Purpose: In 2005, an internal retrospective study at our institution showed a higher incidence of post transplant diabetes mellitus (PTDM) in our Hispanic kidney transplant…
2015 American Transplant Congress
Mycophenolate Dose Reductions Contribute to Suboptimal Graft Outcomes in Kidney Transplant Recipients
K. Boyle, J. Fleming, D. Taber, K. Covert, J. Casale, C. Staino, N. Pilch, C. Mardis, H. Meadows, T. Srinivas, J. McGillicuddy, K. Chavin, C. Bratton, P. Baliga.
Medical University of South Carolina, Charleston, SC.
The purpose of this study was to analyze outcomes in patients with mycophenolate mofetil (MMF) dose reductions below doses proven to prevent rejection in a…
2015 American Transplant Congress
Alemtuzumab Induction Is Protective Against Acute Rejection in Kidney Recipients With Subtherapeutic Tacrolimus Concentrations
K. Szempruch, R.-A. Lee, R. Dupuis, J. Deyo, T. Kozlowski.
Transplant Surgery, University of North Carolina Hospitals, Chapel Hill, NC.
Purpose: To determine the effect of attaining early therapeutic tacrolimus (TAC) trough concentrations on biopsy-proven acute rejection (BPAR) within 12 months post-transplantation in adult kidney…
2015 American Transplant Congress
Verification of OPTN Hepatocellular Carcinoma Recurrence Data
J. George,¹ K. Eddinger,¹ D. Goldberg,² M. Levine,³ P. Abt.³
¹Perelman School of Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA; ²Division of Gastroenterology, Hospital of the University of Pennsylvania, Philadelphia, PA; ³Department of Surgery, Hospital of the University of Pennsylvania, Philadelphia, PA.
PURPOSE: OPTN data on HCC recurrence is increasingly utilized for a variety of studies; however, the accuracy of this data has not been examined. We…
2015 American Transplant Congress
Are We Missing Cardiovascular Disease in Children Awaiting Liver Transplant?
C. Villa,¹ E. Hahn,¹ J. Bucuvalas,² K. Campbell,² R. Hirsch,¹ M. Lake,² A. Lorts.¹
¹Heart Institute, Cincinnati Childrens Hospital, Cincinnati, OH; ²Pediatric Liver Care Center, Cincinnati Childrens Hospital, Cincinnati, OH.
Background: Cirrhotic cardiomyopathy, characterized by low systemic vascular resistance, is increasingly recognized as a complication of end stage liver disease. Yet optimal strategies to screen…
2015 American Transplant Congress
Immunomonitoring By Virus-Specific T Cells After Pediatric Kidney Transplantation (IVIST01-Trial): Study Design and Status
T. Ahlenstiel-Grunow,^1,4 M. Sester,³ U. Sester,² L. Pape.^1,4
¹Pediatric Nephrology, Hannover Medical School, Hannover, Germany; ²Nephrology, Saarland University, Homburg (Saar), Germany; ³Virology, Saarland University, Homburg (Saar), Germany; ⁴Integrated Research and Treatment Center Transplantation, Hannover Medical School, Hannover, Germany.
After kidney transplantation (Tx) immunosuppressive therapy causes an impaired cellular immune defense with an increased risk of viral complications. Virus-specific T cells (Tvis) correlate with…