Am J Transplant, Volume 5, Suppl 3 Archives - Page 105 of 170 - ATC Abstracts

2015 American Transplant Congress
Changes in Immunophenotypes After Conversion from Calcineurin Inhibitors to mTOR Inhibitors in Renal Transplant Recipients
A. Yildiz,^1,4 M. Cavusoğlu,¹ S. Adin,² Y. çaliskan,¹ A. Ozkok,¹ H. Tasçi,³ G. Deniz,² M. Sariyar.³
¹Internal Medicine, Nephrology, Istanbul School of Medicine, Istanbul, Turkey; ²Immunology, Experimental Medicine and Research Center, Istanbul, Turkey; ³General Surgery, Medicana Organ Transplant Center, Istanbul, Turkey.
Chronic toxicity of calcineurin inhibitors (CNI) is one of the major causes of chronic allograft loss. Conversion from CNI to mTOR ((mammalian target of rapamycin)…
2015 American Transplant Congress
Implication of Intragraft γδ T Cell Profiles in Operational Tolerance After Clinical Transplantation of Highly Immunogenic Intestine -Difference from Immunoprivileged Liver
Y. Li,¹ X. Zhao,¹ H. Ohe,² H. Nafady-Hego,³ A. Bishop,⁴ J. Pirenne,⁵ T. Koshiba.⁶
¹Kyoto University, Kyoto, Japan; ²Matsue Red Cross Hospital, Matsue, Japan; ³Assiut Universty, Assiut, Egypt; ⁴University of Sydney, Sydney, Australia; ⁵University of Leuven, Leuven, Belgium; ⁶Fukushima Medical University, Fukushima, Japan.
(Background) T-cell receptor (TCR) Vδ2 γ δ T cells (Vδ 2 cells) participate in host defense, whereas Vδ 1 γ δ T cells (Vδ 1…
2015 American Transplant Congress
Effect of Living Kidney Donation on Glucose Metabolism and Insulin Resistance
B. Tanriover,¹ P. Mohan,² S. Cremers,³ I. Lingvay.⁴
¹Medicine/Nephrology, UT Southwestern, Dallas, TX; ²Medicine/Nephrology, Medical University of South Carolina, Charleston, SC; ³Biomarkers Core Laboratory, Columbia University, New York, NY; ⁴Medicine/Endocrinology, UT Southwestern, Dallas, TX.
The kidney contributes to glucose hemostasis through processes of insulin metabolism, gluconeogenesis, and glucose filtration. Little is known on insulin sensitivity in living kidney donors…
2015 American Transplant Congress
Indefinite Survival of Fully MHC-Mismatched Murine Cardiac Allografts by Combination of Anti-BTLA mAb (6B2) and Anti-PD-1 mAb (PIM-2)
E. Yin,^1,2 M. Uchiyama,^1,3,4 X. Jin,^1,5 T. Shimokawa,³ H. Yagita,⁴ M. Niimi.¹
¹Department of Surgery, Teikyo University, Tokyo, Japan; ²Department of Cardiovascular Surgery, The 2nd Affiliated Hospital of Harbin Medical University, Harbin, China; ³Department of Cardiovascular Surgery, Teikyo University, Tokyo, Japan; ⁴Department of Immunology, Juntendo University Hospital, Tokyo, Japan; ⁵Department of Cardiovascular and Thoracic Surgery, The 4th Affiliated Hospital of Harbin Medical University, Harbin, China.
Background: The co-inhibitory receptor B and T lymphocyte attenuator (BTLA) and Programmed death (PD)-1 had been suggested to have immunomodulatory activity. This study investigated the…
2015 American Transplant Congress
Inhibition of T Cell Metabolism Reveals a New Approach to Preventing Graft Rejection
C.-F. Lee,^1,2 Y.-C. Lo,² G. Furtmüller,³ B. Oh,³ V. Andrade-Oliveira,² A. Thomas,⁴ G. Brandacher,³ J. Powell.²
¹Department of Liver and Transplantation Surgery, Chang-Gung Memorial Hospital-Linkou Branch, Taoyuan, Taiwan; ²Sidney-Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD; ³Department of Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore, MD; ⁴Brain Science Institute, Neurotranslational Program Johns Hopkins University School of Medicine, Baltimore, ND.
Upon antigen recognition and co-stimulation, T cells up-regulate the metabolic machinery necessary to proliferate and sustain effector function. Hallmarks of this response include a switch…
2015 American Transplant Congress
Low Vitamin D Exposure Is Associated With Higher Risk of Infection in Renal Transplant Recipients
L. Sacha,¹ H. Kalluri,² A. Ingemi,³ H. Johnson,⁴ D. Landsittel,⁵ M. Shullo,⁴ R. Venkataramanan.^2,6
¹Department of Pharmacy, Saint Barnabas Medical Center, Livingston, NJ; ²Department of Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, PA; ³Department of Pharmacy, Sentara Norfolk General Hospital, Norfolk, VA; ⁴Department of Pharmacy and Therapeutics, University of Pittsburgh, Pittsburgh, PA; ⁵Department of Medicine, University of Pittsburgh, Pittsburgh, PA; ⁶Starzl Transplant Institute, University of Pittsburgh, Pittsburgh, PA.
PURPOSE: Vitamin D has multiple vital functions within the immune system. This study aims to assess the relationship between vitamin D exposure and the incidence…
2015 American Transplant Congress
Divergence in Risk Factors for Graft Loss and Death Across Race May Mediate Kidney Transplant Outcome Disparity
M. Posadas Salas,¹ D. Taber,² M. Kamel,¹ M. Kadian,¹ M. Salazar,¹ P. Mohan,¹ T. Srinivas.¹
¹Department of Medicine, Medical University of South Carolina, Charleston, SC; ²Department of Surgery, Medical University of South Carolina, Charleston, SC.
Differences in outcomes between African American and non-African American kidney transplant recipients may reflect disparate access to health care. Minimizing this disparity demands a deeper…
2015 American Transplant Congress
Effect of Distinct Immunosuppressive Protocols On the Profile of Cytokines Expression in Renal Transplant Recipients of Extended Criteria Donor Kidneys
C. Montoro Mazeti,¹ C. Zangrossi Dezotti,¹ I. Fernandes-Charpiot,^1,2 H. Caldas,¹ M. Baptista,^1,2 M. Abbud Filho.^1,2,3
¹Laboratory of Immunology and Experimental Transplantation, Sao Jose do Rio Preto Medical School, Sao Jose do Rio Preto, SP, Brazil; ²Department of Medicine, Division of Nephrology, Sao Jose do Rio Preto Medical School, Sao Jose do Rio Preto, SP, Brazil; ³Urology and Nephrology Institute, Urology and Nephrology Institute, Sao Jose do Rio Preto, SP, Brazil.
Background: Transplant recipients (RTx) of kidneys classified as extended criteria (ECD) seems to have worst outcomes when compared with RTx of standard kidneys (SCD) and…
2015 American Transplant Congress
Hepatic Stellate Cells Inhibit T Cells Through Active TGFβ1 from a Cell-Surface-Bound Latent TGFβ1/GARP Complex
Y. Li, B.-G. Kim, S. Qian, J. Letterio, J. Fung, L. Lu, F. Lin.
Immunology, Lerner Research Institute, Cleveland Clinic; 2Pediatric Hematology-Oncology, Case Western Reserve University; 3General Surgery, Digestive Disease Institute, Cleveland Clinic, Cleveland, OH.
Nonparenchymal cells appear to be critical to maintain the immunoprivileged status of liver as whole liver allografts are well-tolerated in mice, but allo-hepatocytes are rapidly…
2015 American Transplant Congress
Phenotype of Renal Tubular Cell Death During Delayed Graft Function
S. Jain,¹ R. Plenter,¹ T. Nydam,¹ C. Ruller,¹ C. Edelstein,^1,2 A. Jani.^1,2
¹University of Colorado, Aurora, CO; ²Veterans Affairs Medical Center, Denver, CO.
Background: Delayed graft function (DGF) independently predicts reduced 5 yr kidney transplant survival. Treatments of DGF are lacking. Cold ischemia (CI) is a significant risk…