Am J Transplant, Volume 5, Suppl 3 Archives - Page 105 of 170 - ATC Abstracts

2015 American Transplant Congress
Regulatory Tolerance Across a Full MHC Barrier Is More Robust Than Tolerance Across a Class I MHC Disparity Alone
M. Madariaga, S. Michel, G. La Muraglia II, M. O'Neil, W. Orent, V. Villani, M. Sekijima, E. Farkash, R. Colvin, J. Allan, K. Yamada, J. Madsen, D. Sachs.
Transplantation Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA.
Background: We previously demonstrated that tolerance of hearts and/or kidneys achieved across a class I MHC mismatch with 12 days of CyA can be abrogated…
2015 American Transplant Congress
Referral for Kidney Transplantation in Georgia: Data from the RaDIANT Community Study
S. Pastan,¹ J. Gander,¹ L. Plantinga,¹ L. Sauls,² E. Gibney,³ L. Mulloy,⁴ J. Krisher,² R. Patzer.¹
¹Emory University, Atlanta; ²Southeastern Kidney Council, Raleigh; ³Piedmont Hospital, Atlanta; ⁴Georgia Regents University, Augusta, GA.
PurposeThe rate of kidney transplantation (KTx) varies significantly across US dialysis facilities. Referral for KTx from dialysis facility providers is the first key step in…
2015 American Transplant Congress
Selective CD28 Blockade With or Without CD40-CD154 Blockade Promotes Cardiac Allograft Protection in Non-Human Primates
T. Zhang,¹ A. Kronfli,¹ B. Gheorghe,¹ L. Burdorf,¹ E. Rybak,¹ D. Parsell,¹ D. Harris,¹ E. Sievert,¹ S. Dahi,¹ N. Kubicki,¹ J. Whoddal,¹ M. Uluer,¹ X. Cheng,¹ E. Schwartz,¹ K. Quinn,¹ B. Vanhove,² A. Azimzadeh,¹ R. Pierson III.¹
¹Surgery, University of Maryland School of Medicine, Baltimore, MD; ²INSERM, U643, Nants, France.
Aim: Selective targeting CD28:B7 costimulation without interfering with CTLA-4-dependent immune regulation is theoretically an attractive approach to modulate pathogenic T cell-dependent immunity. We previously reported…
2015 American Transplant Congress
Everolimus Versus Mycophenolate for Recipients of Kidney Transplants from Expanded Criteria Donors (ECD) Receiving Anti-Thymocyte Globulin and Tacrolimus
H. Tedesco-Silva,¹ C. Felipe,¹ A. Ferreira,¹ M. Cristelli,¹ A. Bessa,¹ P. Ueno,¹ T. Sandes- Freitas,¹ G. Bassos,¹ W. Aguiar,² H. Proença,³ J. Medina-Pestana.¹
¹Nephrology, Hospital do Rim UNIFESP, Sao Paulo, Brazil; ²Urology, Hospital do Rim UNIFESP, Sao Paulo, Brazil; ³Pathology, UNIFESP, Sao Paulo, Brazil.
Introduction: Recipients of kidneys recovered from expanded criteria donors are at higher risk to develop delayed graft function (DGF) and acute rejection (AR), leading to…
2015 American Transplant Congress
Belatacept Based Immunosuppression and Incidence of Proteinuria in Kidney Transplant Recipients
R. Villicana, A. Peng, J. Kahwaji, J. Choi, A. Vo, S. Jordan.
Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA.
Introduction: Abatacept which is a co-stimulation inhibitor has been suggested to have B7-1 mediated antiproteinuric effects. Belatacept which is another co-stimulation agent has been approved…
2015 American Transplant Congress
IL-21 Regulates Creation of Tertiary Lymphoid Organs in Chronic Allograft Rejection
C. Baum,¹ M. Khattar,² P. Schroder,¹ W. Chen,³ S. Stepkowski.¹
¹Medical Microbiology and Immunology, University of Toledo College of Medicine, Toledo, OH; ²Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Boston, MA; ³Transplant Immunology Research Program, Houston Methodist Research Institute, Houston, TX.
BACKGROUND: IL-21 is a cytokine expressed almost exclusively by cells of the adaptive immune system. This makes it an attractive target for reducing chronic allograft…
2015 American Transplant Congress
Clinical and Immunological Update 15 Years After the First VCA – Subsequent Kidney Transplantation After a Bilateral Hand Transplant
A. Weissenbacher,¹ G. Pierer,² M. Gabl,³ M. Ninkovic,¹ T. Hautz,¹ J. Grahammer,¹ B. Zelger,⁴ B. Zelger,⁵ G. Brandacher,⁶ S. Schneeberger.¹
¹Department of Visceral, Transplant and Thoracic Surgery, Innsbruck Medical University, Innsbruck, Austria; ²Department of Plastic, Reconstructive and Aesthetic Surgery, Innsbruck Medical University, Innsbruck, Austria; ³Department of Traumatology, Innsbruck Medical University, Innsbruck, Austria; ⁴Department of Dermatology and Venerology, Innsbruck Medical University, Innsbruck, Austria; ⁵Institute of Pathology, Innsbruck Medical University, Innsbruck, Austria; ⁶Department of Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore, MD.
Background: We herein describe the long term outcome with emphasis on function, immunosuppression (IS), complication and side effects, histomorphology and graft vascular changes 15 years…
2015 American Transplant Congress
Successful Management of Post Transplant Focal Segmental Glomerulosclerosis With Plasma Exchange and Rituximab
K. Koutroutsos,¹ R. Charif,¹ C. Roufosse,² J. Galliford,¹ D. Taube,¹ M. Loucaidou.¹
¹Kidney and Transplant Centre, Imperial Healthcare NHS Trust, London, United Kingdom; ²Department of Histopathology, Imperial Healthcare NHS Trust, London, United Kingdom.
Background: Post-transplant Focal Segmental Glomerulosclerosis (FSGS) is associated with renal allograft loss. Currently, optimal treatment remains controversial. We propose a management protocol that includes treatment…
2015 American Transplant Congress
Molecular Correlates of Atrophy-Fibrosis in Human Kidney Transplants Provides a New Model of Renal Fibrosis
J. Venner, K. Famulski, P. Halloran.
University of Alberta, Edmonton, Canada.
We studied the effect of time post-transplant on atrophy-fibrosis (AF) and the molecular associations with AF in 703 kidney transplant indication biopsies (bx) 3 days…
2015 American Transplant Congress
Combination of Non-HLA and HLA-DSA Antibodies Identifies Liver Transplants Recipients With Highest Risk for Fibrosis Progression and Mortality
J. O'Leary,¹ J. Cai,² H. Heidecke,³ L. Jennings,¹ A. Philippe,⁴ V. Harbour,¹ R. Catar,⁴ P. Terasaki,² G. Klintmalm,¹ D. Dragun.⁴
¹Simmons Transplant Institute, Baylor University Medical Center, Dallas, TX; ²Terasaki Foundation Laboratory, Los Angeles, CA; ³Celltrend, Berlin, Germany; ⁴Nephrology & Intensive Care Medicine, Charite Berlin, Berlin, Germany.
Recent data has shown an increased risk of fibrosis progression in HCV viremic liver transplant (LT) recipients with HLA DSA in serum. However, the role…