ATC Abstracts

American Transplant Congress abstracts

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  • 2013 American Transplant Congress

    Mycophenolic Acid (MPA) Dosing: Effect on Efficacy to 4 Years after Kidney Transplantation in the Mycophenolic Acid Observational Renal Transplant (MORE) Study

    L. Chan, F. Shihab, O. Pankewycz, C. Doria, A. Wiland, K. McCague, A. Langone

    University of Colorado School of Medicine, Aurora, CO; University of Utah School of Medicine, Salt Lake City, UT; Erie County Medical Center, Buffalo, NY; Thomas Jefferson University Hospital, Philadelphia, PA; Novartis Pharmaceuticals Corporation, East Hanover, NJ; Vanderbilt University Medical Center, Nashville, TN

    Maintaining adequate MPA dose may be important to optimize efficacy after kidney transplantation, but prospective long-term data are rare.Methods. MORE was a prospective, observational study…
  • 2013 American Transplant Congress

    Epigenetic Analysis of the TSDR of FOXP3 Demonstrates That Natural Treg Infiltrate the Cardiac Allograft Already before an Acute Rejection Episode

    K. Boer, A. Peeters, A. Maat, K. Caliskan, A. Balk, W. Weimar, C. Baan

    Internal Medicine, Erasmus University Medical Center, Rotterdam, Netherlands; Thoracic Surgery, Erasmus University Medical Center, Rotterdam, Netherlands; Cardiology, Erasmus University Medical Center, Rotterdam, Netherlands

    IntroductionTwo subtypes of FOXP3+ regulatory T cells (Treg) have been identified. Natural (n) Treg originate in the thymus, while antigen specific induced (i) Treg are…
  • 2013 American Transplant Congress

    How To Handle a Missed or Delayed Dose Intake? A Pharmacokinetic Study of Cyclosporine and Tacrolimus in Renal Transplant Patients

    F. Saint-Marcoux, J. Woillard, J. Friedl, F. Bocquentin, M. Essig, P. Marquet

    Pharmacology, CHU Limoges, Limoges, France; INSERM UMR-S850, Univ. Limoges, Limoges, France; Nephrology, CHU Limoges, Limoges, France

    BACKGROUND and OBJECTIVES: Despite the efforts made to optimize adherence, every transplant patient will, at least occasionally, miss doses or take them outside the prescribed…
  • 2013 American Transplant Congress

    Natural History of the Arteriovenous Access and Risk Factors Affecting Spontaneous Closure after Successful Kidney Transplantation, The

    J. Kim, J. Hwang, S. Park, C. Yang, I. Moon

    Surgery, The Catholic University of Korea, Seoul, Republic of Korea; Internal Medicine, The Catholic University of Korea, Seoul, Republic of Korea

    Purpose; After successful kidney transplantation (KT), arteriovenous access (AVA) is neither used nor useful. There are many debates whether to preserve an AVA or to…
  • 2013 American Transplant Congress

    Does African American (AA) Ethnicity Affect Kidney Transplant Outcomes at Four Years? An Analysis of the Mycophenolic Acid Observational Renal Transplant (MORE) Study

    M. Narayanan, O. Pankewycz, F. Shihab, A. Wiland, K. McCague, L. Chan

    Scott and White Healthcare, Temple, TX; Erie County Medical Center, Buffalo, NJ; University of Utah School of Medicine, Salt Lake City, UT; Novartis Pharmaceuticals Corporation, East Hanover, NJ; University of Colorado School of Medicine, Aurora, CO

    Prospective data regarding kidney transplant outcomes in AA kidney transplant patients using modern immunosuppressive regimens are limited.Methods: MORE was a 4-year, prospective, observational study at…
  • 2013 American Transplant Congress

    Cost of Sepsis in a Program Utilizing Indefinite Sulfamethoxazole-Trimethoprim Prophylaxis in Renal Transplant Recipients

    T. Horwedel, L. Bowman, D. Brennan

    Pharmacy, Barnes-Jewish Hospital, St. Louis, MO; Medicine, Washington University, St. Louis, MO

    Background: Sepsis represents a significant cost and disease burden to the renal transplant recipient, adversely impacting both patient and graft survival. Sulfamethoxazole-trimethoprim (SMX-TMP) is a…
  • 2013 American Transplant Congress

    Outcomes of Transplantation for Uncontrolled HCC and Rescue with Marginal Quality Grafts

    P. Porrett, E. Baranov, A. Shaked, K. Olthoff

    Surgery, University of Pennsylvania, Philadelphia, PA

    Introduction We examined the survival of patients transplanted for progressive hepatocellular cancer (HCC) not controlled with locoregional therapy (LRT) and the impact of the strategy…
  • 2013 American Transplant Congress

    Economic Impact of Pulsatile Hyothermic Perfusion in an Expanded Criteria Donor Transplant Program. Analysis of the First Year Implementation

    V. Gómez, V. Diéz, C. Galeano, A. Gomis, V. Hevia, M. Jiménez, R. Rodriguez-Patrón, F. Arias, C. Quereda, F. Burgos

    Urology, Ramón y Cajal Hospital, Madrid, Spain; Nephrology, Ramón y Cajal Hospital, Madrid, Spain; Alcalá University, Madrid, Spain

    INTRODUCTIONKidney transplant (KT) from expanded criteria donors (ECD) have a higher rate of delayed graft function (DGF) that increases postoperative costs because of prolonged hospital…
  • 2013 American Transplant Congress

    Characterization of the Immune Response after Intravenous Infusion of Mesenchymal Stem Cells

    M. Hoogduijn, M. Roemeling-van Rhijn, A. Engela, S. Korevaar, F. Mensah, M. Franquesa, R. de Bruin, M. Betjes, W. Weimar, C. Baan

    Internal Medicine, Erasmus Medical Center, Rotterdam, Netherlands; Surgery, Erasmus Medical Center, Rotterdam, Netherlands

    Experimental animal models show beneficial effects of administration of mesenchymal stem cells (MSC) on ischemia-reperfusion injury and survival of organ transplants. The immunomodulatory responses that…
  • 2013 American Transplant Congress

    Can the Risk of Cancer Transmission from Organ Donors Be Eliminated?

    R. Desai, D. Collett, C. Watson, P. Johnson, T. Evans, J. Neuberger

    Organ Donation and Transplantation, NHS Blood and Transplant, Bristol, United Kingdom; Department of Surgery, Addenbrooke's Hospital, Cambridge, United Kingdom; School of Cancer Sciences, University of Birmingham, Birmingham, United Kingdom; West Midlands Cancer Intelligence Unit, University of Birmingham, Birmingham, United Kingdom

    Donor origin cancer (DOC) in transplant recipients may be transmitted with the graft (donor-transmitted cancer [DTC]) or develop subsequently from the graft (donor-derived cancer [DDC]).…
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