ATC Abstracts

American Transplant Congress abstracts

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  • 2013 American Transplant Congress

    Critical Role of Notch-2 Signaling in Alloantibody Production

    C. Magee, T. Shimizu, S. Ohori, C. Siebel, N. Najafian, L. Riella

    Transplantation Research Center, Brigham & Women's Hospital, Harvard Medical School, Boston; Genentech, South San Francisco

    The role of B cells in the alloimmune response is increasingly recognized, while alloantibody production remains a major barrier to the improvement of long-term graft…
  • 2013 American Transplant Congress

    Proteinkinase C Alpha Contributes to Impairment of Renal Blood Flow and Inflammation in Hypoxia Induced Renal Ischemia Reperfusion Injury (IRI)

    D. Walacides, N. Rüskamp, R. Song, K. Hueper, M. Mengel, M. Meier, H. Haller, M. Schiffer, F. Gueler

    Nephrology, Medical School Hannover, Hannover, Germany; Radiology, Medical School Hannover, Hannover, Germany; Applied Genomics Center, University of Alberta, Edmonton, Canada; Cental Animal Facility, Medical School Hannover, Hannover, Germany

    Background – Renal ischemia reperfusion injury (IRI) leads to delayed graft function (DGF) after kidney transplantion and contributes to acute transplant rejection as well as…
  • 2013 American Transplant Congress

    Evidence for Renal Tubular Epithelial Cells as Another Source of IL-17 Producing Cells

    H. Zhou, L. Xue, Y. Wang, J. Liu, L. Zhang, J. Yu

    Urologic Diseases Center, The First Bethune Hospital, Jilin University, Changchun, Jilin, China; Key Laboratory of Pathobiology, Ministry of Education, School of Basic Medical Sciences, Jilin University, Changchun, Jilin, China; Urologic Surgery Department, Laigang Hospital,Taishan Medical University, Taishan, Shandong, China

    Interleukin-17(IL-17) is mainly produced by a subset of CD4+T cells (TH17) .The exact source of IL-17 expression in renal graft during rejection remians unclear. A.Loverre…
  • 2013 American Transplant Congress

    Bilirubin Improvement Correlates with 90-Day Survival with Use of the ELAD® System in a Randomized, Controlled Study of Subjects with Acute Alcoholic Hepatitis or Acute Decompensation of Cirrhosis

    L. Teperman, The ELAD Study Group

    Mary Lea Johnson Richards Organ Transplantation Center, NYU SOM, New York, NY

    Background: ELAD, a human cell-based liver support system, circulates ultrafiltrated patient plasma through a hollow fiber cartridge containing active immortalized C3A human liver cells. Studies…
  • 2013 American Transplant Congress

    Association between Early Progression in Chronic Kidney Disease Stage Following Liver Transplantation and Graft Survival

    W. Irish, P. Massa, M. Tran, P. Bernhardt, J. Ricci

    CTI Clinical Trial and Consulting Svcs, Raleigh; Novartis Pharmaceuticals Corporation, East Hanover; Novartis Pharma AG, Basel, Switzerland; Wellmera AG, Basel, Switzerland

    Introduction: Renal dysfunction before and after liver transplantation is a significant predictor of graft survival (GS). This study aims to characterize the relationship between early…
  • 2013 American Transplant Congress

    Development of De Novo Anti-HLA Abs in Kidney Transplant Recipients: Final Analysis of the NIH CTOT02 Study

    A. Chandraker, I. Guleria, D. Ikle, H. Chin, F. Vincenti, Y. Morrison, N. Bridges, W. Harmon, M. Sayegh

    Brigham and Women's Hospital and Boston Children's Hospital, Harvard Medical School, Boston; RHO, Chapel Hill, NC; UCSF, San Francisco; NIH, Bethesda, MD

    The NIH CTOT02 is the first large multi-center prospective study to examine the causes and effects of development of post-transplant de novo anti-HLA Ab in…
  • 2013 American Transplant Congress

    Influenza Vaccination and Humoral Alloimmunity in Solid Organ Transplant Recipients

    P. Vermeiren, V. Aubert, R. Sugamele, J. Aubert, J. Venetz, P. Meylan, M. Pascual, O. Manuel

    Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland

    Background: Annual influenza vaccination is usually recommended in solid-organ transplant (SOT) recipients. However, concerns have been raised about the impact of vaccination on alloimmunity. We…
  • 2013 American Transplant Congress

    Prolonged Delayed Graft Function Is Associated with Inferior Patient and Kidney Allograft Survivals

    T. Sandes-Freitas, R. Klein, H. Tedesco, J. Medina- Pestana

    Nephrology Division, Hospital do Rim e Hipertensão, São Paulo, Brazil

    Introduction: The incidence of delayed graft function (DGF) is variable according to donor/recipients demographics. It is still unclear the influence of DGF on clinical outcomes…
  • 2013 American Transplant Congress

    Successful Reduction and Cessation of Immunosuppressants by a Regulatory T Cell-Based Cell Therapy in Living Donor Liver Transplantation: A Pilot Study for Tolerance Induction

    K. Yamashita, M. Zaitsu, A. Nagatsu, R. Goto, T. Oura, M. Watanabe, T. Aoyagi, T. Suzuki, T. Shimamura, N. Sato, J. Sugita, K. Hatanaka, M. Taniguchi, H. Furukawa, H. Bashuda, K. Okumura, S. Todo

    Hokkaido University, Sapporo, Japan; Asahikawa Medical College, Asahikawa, Japan; Juntendo University, Tokyo, Japan

    Purpose: Life-long use of immunosuppressants (IS) is associated with significant immunological and non-immunological adverse effects. Thus, minization, followed by complete cessation of IS has been…
  • 2013 American Transplant Congress

    Carbapenem Resistant Klebsiella Pneumoniae (CRKP) Infection in Solid Organ Transplant Recipients (SOT): A Single Center Analysis

    P. Grossi, A. Mularoni, M. Campanella, G. Vizzini, P. Conaldi, B. Gridelli

    ISMETT/UPMC, Palermo, Italy; Surgical and Morphological Sciences, University of Insubria, Varese, Italy

    BACKGROUND: The incidence of Multi-drug-resistant bacterial infections among SOT recipients is steadily increasing. Aim of the present is to describe the epidemiology and outcome of…
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