BACKGROUND: The incidence of Multi-drug-resistant bacterial infections among SOT recipients is steadily increasing. Aim of the present is to describe the epidemiology and outcome of CRKP infection in SOT at our center.
METHODS: We performed a retrospective analysis of prospectively collected data on SOT recipients colonized and/or infected by CRKP from January 2009 to October 2012.
RESULTS: From January 2009 to October 2012, 492 patients underwent a SOT at our centre. CRKP was isolated in 68 of them (13.8%) but only 36 had a symptomatic CRKP infection (7.3%). 17 patients developed a CRKP infection during the early 30 days after SOT, 10 between 31 and 60 days after SOT and 9 patients more than 60 days after transplantation. 11 of the 36 infected patients (30.5%) died compared to only 2 patients among the 32 who were just colonized (6.2%). Number and type of transplants, SOT recipients with CRKP colonization and infection and number of episodes by type of infection in the study period are shown in the table.
DISCUSSION: The number of SOT recipients with CRKP isolation in our center has markedly increased over the last few years. CRKP infection tend to occur early after transplantation. 27/36 (75%) of the symtomatic infections occurred in fact during the first two months after transplantation. A very high mortality rate has been observed in patients with symptomatic infection. It is extremely important to monitor this type of infection in order to implement appropriate infection control measures and treatment strategies.
To cite this abstract in AMA style:Grossi P, Mularoni A, Campanella M, Vizzini G, Conaldi P, Gridelli B. Carbapenem Resistant Klebsiella Pneumoniae (CRKP) Infection in Solid Organ Transplant Recipients (SOT): A Single Center Analysis [abstract]. Am J Transplant. 2013; 13 (suppl 5). https://atcmeetingabstracts.com/abstract/carbapenem-resistant-klebsiella-pneumoniae-crkp-infection-in-solid-organ-transplant-recipients-sot-a-single-center-analysis/. Accessed July 24, 2021.
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