2013 American Transplant Congress
Flt3 Ligand Induces STAT3-Independent Expansion and Activation of Myeloid-Derived Suppressor Cells Able To Promote Heart Allograft Survival
Surgery, Starzl Transplant Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA
Introduction: Fms-like tyrosine kinase 3 ligand (Flt3L) is essential for myeloid cell homeostasis, particularly dendritic cells (DC), and acts through STAT3 to promote DC expansion.…2013 American Transplant Congress
Screening for Inherited and Acquired Thrombophilia Prior to Renal Transplantation
All patients with a history of a thromboembolic event, early or recurrent vascular access thrombosis, family history of thrombosis, or multiple miscarriages underwent laboratory screening…2013 American Transplant Congress
Comparison of Baseline and Day 28 Post Transplant Renal Allograft Samples from the CTOT-10 Belatacept Study
The purpose of the CTOT-10 study is to evaluate belatacept as maintenance therapy, while minimizing calcineurin inhibitors and corticosteroids in renal transplantation. We designed mechanistic…2013 American Transplant Congress
Rationale for, and the Economic Implications Associated with, Extending Medicare Coverage for Immunosuppressive Medications to Kidney Transplant Recipients Who Lack Insurance Coverage, The
United Network for the Recruitment of Transplantation Professionals, Rochester, MN
Immunosuppressive medications are essential in preventing kidney transplant rejection. Continuous insurance coverage for outpatient immunosuppressive medications remains a major issue. The objective of this analysis…2013 American Transplant Congress
Uniform Long-Term Graft Survival in a Clincial Trial of the Induction of Tolerance to Kidney Transplants
Stanford University, Stanford, CA
Purpose: Over the last 12 years we have studied the safety and efficacy of a clinical tolerance induction protocol using hematopoietic cell transplantation in combination…2013 American Transplant Congress
Development of Hepatic Ischemia and Reperfusion Injury Is Independent of Myeloid Cell-Derived COX-2
David Geffen School of Medicine UCLA, Los Angeles
Cyclooxygenase-2 (COX-2) is a powerful mediator of hepatic ischemia/reperfusion injury (IRI). While COX-2 depletion significantly ameliorates liver IRI, COX-2 inhibitors present clinical limitations; Therefore, there…2013 American Transplant Congress
Mechanical Trauma Can Reactivate an Alloimmune Response Against the Skin-Component in a Large Animal Vascularized Composite Allotransplantation (VCA) Model of Operational Tolerance
Plastic and Reconstructive Surgery, Johns Hopkins University, Baltimore
BACKGROUND: The skin component of Vascularized Composite Allografts (VCA) is unique since it is directly exposed to the environment. It thereby not only offers opportunities…2013 American Transplant Congress
Mixed Acute Rejection: Comparison of Therapeutic Results with Anti-T Cell Antibody- and Proteasome Inhibitor-Based Regimens
University of Cincinnati; The Christ Hospital
Background: Mixed acute rejection (MAR) has been defined as acute rejection consisting of both cellular and humoral components. No data exist regarding MAR treatment outcomes,…2013 American Transplant Congress
Absence of the MicroRNA miR-182 in CD4+T Cells Prolongs Allograft Survival
Department of Surgery/Division of Abdominal Transplantation, Stanford University, Stanford, CA
MicroRNAs (miRNAs) are small non-coding RNA molecules that regulate the post-transcriptional expression of target genes and are important regulators in many biologic processes including innate…2013 American Transplant Congress
Vancomycin-Resistant Enterococcus (VRE) Surgical Infection Following Liver Transplant (LT)
University of Pittsburgh, Pittsburgh
Background: VRE infection occurs in about 10% of LT patients (pts) and is associated with increased length of hospital stay and decreased survival. Some risk…
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