Plasma Osteopontin Levels Correlate with Reversible Kidney Injury in Liver Transplant Candidates
Comprehensive Transplant Center, Northwestern University Department of Surgery, Chicago, IL
The Scripps Research Institute, Lajolla, CA
Myriad RBM, Austin, TX
Meeting: 2013 American Transplant Congress
Abstract number: 142
Background: Predicting post-liver transplant (LT) recovery of renal dysfunction (RD) remains a significant clinical challenge. Biomarkers predictive of recovery would be helpful in the management of pre-LT patients with RD and would complement clinical and laboratory data in decision algorithms regarding the need for a simultaneous liver-kidney (SLK) transplant.
Aim: To validate a previously identified association between plasma proteomic biomarkers and post-LT renal recovery in patients with distinct clinical phenotypes: Hepato-Renal Syndrome (HRS), non-HRS Acute Kidney Injury (AKI), and Chronic Kidney Disease (CKD).
Methods: Using a novel renal injury proteomic panel of 13 proteins from Myriad/RBM, Inc., plasma samples were collected at the time of transplant in patients clinically stratified into 4 groups (clinical phenotypic stratification was achieved using both pre- and post-LT clinical and laboratory data). HRS (Group 1): RD clinically characterized as HRS, recovered post-LT; non-HRS AKI (Group 2): RD not clinically characterized as HRS, did not fully recover RD post-LT; CKD (group 3): known CKD, received SLK; A negative control group consisted of patients with no pre-LT RD (Group 4).
Group | n | age (yrs) | MELD | Cr at LT(mg/dl) |
1 | 11 | 60.7+/-2.4 | 28.7+/-3.2 | 3.4+/-0.71 |
2 | 25 | 57+/-1.8 | 27.6+/-2.6 | 2.5+/-0.27 |
3 | 4 | 57.8+/-6.4 | 21.2+/-2.7 | 1.8+/-0.4 |
4 | 18 | 54.8+/-2.4 | 15.3+/-1.3 | 1.18+/-0/1 |
Results: Two plasma proteins (Osteopontin, OPN; Vascular Endothelial Growth Factor, VEGF) were elevated in both Group 1 (HRS) and Group 2 (non-HRS AKI) (Bonferroni-adjusted p-values < 0.05). However, only OPN was uniquely elevated in patients with HRS, whose RD recovered fully within 6 weeks of transplantation (p<0.05).
Conclusion: These data validate our previous findings suggesting that plasma OPN levels are associated with the HRS clinical phenotype and may be used as a predictive biomarker for recovery of RD post-LT.
To cite this abstract in AMA style:
Baker T, Levitsky J, Al-Saden P, Solomon D, Ballard K, Jie C, Abecassis M. Plasma Osteopontin Levels Correlate with Reversible Kidney Injury in Liver Transplant Candidates [abstract]. Am J Transplant. 2013; 13 (suppl 5). https://atcmeetingabstracts.com/abstract/plasma-osteopontin-levels-correlate-with-reversible-kidney-injury-in-liver-transplant-candidates/. Accessed December 13, 2024.« Back to 2013 American Transplant Congress