2013 American Transplant Congress
Donor Comorbidities Rather Than Age Alone Determine Recipient Outcomes in "SCD" Kidney Transplants
The Transplant Institute, Henry Ford Hospital, Detroit, MI
Deceased donor (DD) pool has been expanded with kidneys that have wide-ranging functional vitality and pathologic features stemming from increasing incidence of metabolic syndrome. To…2013 American Transplant Congress
Non-Renal Solid Organ Transplant (NRSOT): The Role of the Transplant Nephrologist before Advanced Stage Chronic Kidney Disease (CKD)
Background: Many patients who have not undergone appropriate kidney evaluation pre-NRSOT are found to have progressive or end-stage renal disease post-NRSOT. Recipients of NRSOT who…2013 American Transplant Congress
Parent and Child Perceptions of Long Term Psychosocial Functioning at > 5 Years Post-Intestine Transplant (ITx)
With improved survival following pediatric ITx, evaluating psychosocial outcomes in the long term is essential. Aim: Describe psychosocial outcomes of long term survivors at >…2013 American Transplant Congress
CTLA-4 Ig Prevents Chronic Antibody-Mediated Rejection
Emory Transplant Center, Atlanta
[Background] Chronic rejection of organ transplants remains an unsolved problem in the field of transplantation. Humoral immunity, typically manifesting as alloantibody, is increasingly recognized as…2013 American Transplant Congress
Decreased mTORC1 and Increased mTORC2 Activity Is Essential for Protective Differentiation Programs in Mesenchymal Stem Cells
mTOR translates microenvironmental signals into cell differentiation responses and controls cell fate including authophagy and apoptosis. Phenotypic conversion of mesenchymal stem cells (MSC) towards osteoblast…2013 American Transplant Congress
SCD Kidneys Defined by Age, but Associated with ECD-Defining Comorbidities Result in Inferior Recipient Outcomes
The Transplant Institute, Henry Ford Hospital, Detroit, MI
Studies of Expanded Criteria Donor (ECD) kidney (K) transplantation confirm lower allograft survival compared to Standard Criteria Donor (SCD)and donor age has been strongly implicated…2013 American Transplant Congress
Combined Liver-Kidney Transplantation: Simultaneous Versus Delayed Transplantation of the Kidney Graft
Transplant Division, Department of Surgery, Indiana University School of Medicine, Indianapolis, IN
Purpose: Patients requiring combined liver and kidney transplantation (LK) are at risk for worse outcomes because of severity of illness and complexity of the procedure.…2013 American Transplant Congress
Cutaneous Collateral Axonal Sprouting Re-Innervates the Skin Component and Restores Sensation of Denervated Swine Osteomyocutaneous Allografts
BACKGROUND: Reconstructive transplantation is a viable treatment option for select patients with devastating tissue loss. However, sensorimotor recovery is critical determinant of its overall success.…2013 American Transplant Congress
Rapamycin Enhances Early Alloantibody Production by Hampering the Homeostatic Proliferation of Regulatory T Cells
Emory Transplant Center, Atlanta; Department of Pathology, Emory University, Atlanta
[Background] Antibody-mediated chronic rejection is one of the main obstacles to achieving long-term success of transplant. We demonstrated that alemtuzumab induction with rapamycin maintenance therapy…2013 American Transplant Congress
Ten-Year Experience in Pediatric Renal Transplant Using Thymoglobulin Induction and Steroid Minimization
Introduction: Our center has offered steroid minimized, thymoglobulin induction to our pediatric renal transplant patients for the last 10 years. Steroid minimization or avoidance in…
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