2013 American Transplant Congress
True MELD Score Is Associated with HCC Patient Outcomes after Liver Transplant
Introduction:Patients with in-criteria HCC listed for liver transplantation(OLT) receive exception MELD scores(EM) not adjusted for disease severity unless the calculated, true MELD score(TM) exceeds the…2013 American Transplant Congress
DAP12 Deficiency in Liver Allografts Enhances Donor DC Migration, Host Alloimmunity and Breaks Liver Transplant Tolerance
Background: Fully MHC-mismatched mouse liver allografts are accepted without immunosuppressive therapy and induce donor-specific tolerance. Liver dendritic cells (DC) exhibit an immature phenotype that may…2013 American Transplant Congress
Role of Innate and Adaptive Immunity in Survival and Neurogenesis of Neural Progenitor Cell Grafts, The
Surgery, Stanford University SOM, Stanford, CA; Neurosurgery, Stanford University SOM, Stanford, CA
Neural Progenitor Cells (NPC) are multipotent progenitors found within the brain that differentiate into neurons, oligodendrocytes, and astrocytes. Transplantation of NPC has been proposed as…2013 American Transplant Congress
Telomere Length of Living Kidney Donors and Recipients and Chronic Graft Dysfunction in Kidney Transplants
University of Minnesota, Minneapolis, MN
Background: Telomeres consist of multiple copies (100s to 1000s) of short (6 nucleotide) repeats at the end of all chromosomes, playing a protective role against…2013 American Transplant Congress
Humoral Rejection of Human Kidney Grafts Associates with Polyreactive Antibodies That Bind Apoptotic Cells and Activate Complement
Massachusetts General Hospital, Boston; University Hospital of Parma, Parma, Italy
Antibody Mediated Rejection (AMR) is associated with a variety of graft-reactive antibodies following kidney transplant. To characterize these antibodies, we immortalized 107 B cell clones…2013 American Transplant Congress
Lung Allograft Tolerance in Non-Human Primates Via Establishment of Stable Mixed Hematopoietic Chimerism
Transplantation tolerance of kidney allografts has been achieved in both non-human primates (NHPs) and patients using a non-myeloablative conditioning regimen, costimulation blockade, and infusion of…2013 American Transplant Congress
Protective Effect of a FDA-Approved Intralipid on Kidney Ischemia/Reperfusion Injury
BACKGROUND: Ischemia/reperfusion injury (IRI) resulting from the procedure of transplantation has a negative impact on both short- and long- time graft survival. Early activation of…2013 American Transplant Congress
Preliminary Psychometric Properties of a Measure of the Allocation of Responsibility for Health Management Tasks in Pediatric Liver Transplant Recipients
University of Michigan, Ann Arbor, MI
Purpose: The shift in responsibility for health-related tasks from parents to adolescents is essential to the transition to adult care. This study reports the preliminary…2013 American Transplant Congress
Evidence for Decreased Cellular and Humoral Renal Allograft Rejection in Combined Liver-Kidney Transplants
Combined liver-kidney transplantation (CLKT) has been widely thought to have an immunoprotective effect on the kidney. However, detailed studies are lacking. The goal of this…2013 American Transplant Congress
Rapamycin-Resistant mTORC1 Regulates Dendritic Cell B7-H1 Expression That Acts in Synergy with IL-1β To Promote Regulatory T Cell Induction
Introduction: The mammalian Target of Rapamycin (mTOR) is targeted clinically with rapamycin (RAPA) to prevent allograft rejection. mTOR functions in two mTOR-containing complexes, – mTOR…
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