Purpose: Arterial stiffness is an independent predictor for cardiovascular mortality. In end stage renal disease cardiovascular risk factors such as age, hypertension and diabetes mellitus have been confirmed to be positively correlated with arterial stiffness. Although renal transplantation improves survival, cardiovascular morbidity and mortality still remain as a significant problem. The aim of this study is to evaluate the risk factors for arterial stiffness in kidney transplant recipients.
Methods: One hundred and forty five kidney transplant recipients were enrolled into the study. All patients were evaluated for their standard clinical, biochemical parameters and pre-transplantation lipid parameters. Waist and hip circumferences (WC, HC); and sagittal abdominal diameter (SAD) were assessed. PWv was determined from pressure tracing over carotid and femoral arteries using the SphygmoCor system.
Results: Carotid-femoral PWv was significantly related with age (p:0.001; r:0.312), systolic (p:0.039; r:0.336) and diastolic blood pressure (p:0.007; r:0.246), uric acid (p:0.0001; r:0.348), hemoglobin (p:0.02; r:0.203), pre-transplant serum total cholesterol (r:0,266, p:0,01) and LDL-C (r: 0,303, p: 0,02) levels. However duration of hemodialysis, post-transplant time, serum albumin, pre-transplant serum triglyceride and HDL-C levels were not significantly related with PWv. Patients were divided into two groups according to PWv levels. The frequency of patients with PWv > 7 m/s was higher in patients with hypertension (SBP > 140 mmHg), age > 50 years, male gender, hyperurisemia (uric acid level > 7 mg/dl), hemoglobin level > 12 g/dl (p:0.029, 0.02, 0.005, 0.001, 0.023). Pre-transplant hyperlipidemia predicts higher PWv levels in post-transplant period (OR: 2.5, CI:1.1-5.7). PWv was significantly associated with WC and SAD (p:0.048; r:0.188, p:0.041; r:0.288).
Conclusions: Pretransplant hyperlipidemia predicts arterial stiffness in post-transplant period. For cardiovascular risk reduction after renal transplantation; blood pressure, serum glucose and uric acid levels should be under strict control.
To cite this abstract in AMA style:Uyar MErkmen, Tutal E, Bal Z, Demirci BGurlek, Guliyev O, Hasdemir E, Colak T, Acar FOzdemir, Sezer S, Haberal M. Associations between Clinical, Biochemical Indicators and Anthropometric Measurements with Arterial Stiffness in Renal Transplantation Patients [abstract]. Am J Transplant. 2013; 13 (suppl 5). https://atcmeetingabstracts.com/abstract/associations-between-clinical-biochemical-indicators-and-anthropometric-measurements-with-arterial-stiffness-in-renal-transplantation-patients/. Accessed April 22, 2021.
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