Am J Transplant, Volume 22, Suppl 3 Archives - Page 92 of 190 - ATC Abstracts

2022 American Transplant Congress
Differences of Fk-Binding Protein 12 and P-Glycoprotein Explain the Differences in the Intracellular Tacrolimus Concentration of T Lymphocytes and Monocytes
S. Udomkarnjananun, C. Baan, B. de Winter, D. Hesselink
Erasmus MC, Rotterdam, Netherlands
*Purpose: Little is known about the pharmacokinetics of intracellular tacrolimus, particularly in T lymphocytes and monocytes. We demonstrated a significantly lower intracellular tacrolimus concentration in…
2022 American Transplant Congress
The Higher Cost of Donation After Circulatory Death Liver Transplantation Starts with Acquisition Costs: A Single Center Comparison Liver Acquisition Fees by Donor Type
V. Reddy¹, S. Asrani², J. Trotter², R. Ruiz³, S. Lee², E. Martinez², N. Onaca², G. McKenna⁴, A. Gupta², H. Fernandez², J. Bayer², G. Testa², A. Wall²
¹Baylor Scott and White Research Institute, Allen, TX, ²Baylor University Medical Center, Dallas, TX, ³Baylor University Medical Center, Fort Worth, TX, ⁴Baylor Simmons Transplant Inst, Dallas, TX
*Purpose: Donation after circulatory death (DCD) donors are an increasing proportion of deceased donor population in the US. One drawback of DCD donors is that…
2022 American Transplant Congress
Technical Report to Increased Utilization of Injured Kidneys: CT Scan to Evaluate Organ and Reduce Discard
V. E. Whittaker
Surgery, Columbia Vagelos College of Physicians and Surgeons, New York, NY
*Purpose: To reduce discard of injured kidneys with parenchymal injury or perinephric hematoma . Young donors with good function but injury are at high risk…
2022 American Transplant Congress
Impact of Changing Tacrolimus Formulation on Cerebral Blood Flow and Cognitive Function
I. Mahaparn, R. Lepping, R. N. Montgomery, R. Mukherjee, S. Billinger, W. M. Brooks, A. Gupta
University of Kansas Medical Center (KUMC), Kansas City, KS
*Purpose: To assess if switching to extended release (ER) tacrolimus changes cerebral blood flow (CBF) or cognitive function after switching stable kidney transplant (KT) recipients…
2022 American Transplant Congress
TNFRSF13B Genotype Determines the Properties of Donor-Specific B Cells
M. Cascalho¹, M. Garcia de Mattos Barbosa¹, T. Pasieka¹, E. Farkash², R. Sung³, M. Doshi⁴, J. Platt⁴
¹Surgery, University of Michigan, Ann Arbor, MI, ²Pathology, University of Michigan, Ann Arbor, MI, ³University of Michigan Health System, Ann Arbor, MI, ⁴University of Michigan, Ann Arbor, MI
*Purpose: The TNFRSF13B gene is among the 5% most polymorphic genes in humans. The phenotypes of the most frequent TNFRSF13B variants in humans and mice…
2022 American Transplant Congress
Donor Genetic Background Predisposes Differentiation and Accumulation of Regulatory T Cells in the Kidney Allografts
X. Lai¹, J. Wang¹, S. Han¹, C. Chunlei¹, L. VanOsdol¹, L. Gallon², J. Leventhal², M. Kandpal¹, Z. Zhang¹
¹Comprehensive Transplant Center, Microsurgery core, Northwestern University Feinberg School of Medicine, Chicago, IL, ²Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL
*Purpose: We have previously demonstrated that donor kidney-intrinsic innate immunity determines the severity of delayed graft function (DGF) in kidney transplantation and potentiates long kidney…
2022 American Transplant Congress
Association of Chest CT Score During Acute COVID-19 Illness with Subsequent Lung Function Loss Among Lung Transplant Patients
Q. M. Halverson, K. Batra, L. D. Mahan, M. Mohanka, A. C. Lawrence, J. Joerns, S. Bollineni, V. Kaza, I. L. Timofte, C. D. Kershaw, L. C. Terada, F. Torres, A. Banga
University of Texas Southwestern, Dallas, TX
*Purpose: Limited data exists on CT chest abnormalities during acute Coronavirus disease 2019 (COVID-19) infection and associated post-illness loss of lung function among lung transplant…
2022 American Transplant Congress
Single Cell And Spatial Transcriptomics Of Blood And Biopsies Reveals Enhanced Alloantigen Presenting Function And T-follicular Helper Cell (tfh) Expansion Early After Pediatric Liver Transplantation
R. Sindhi¹, C. Ashokkumar¹, M. Ningappa¹, D. Rajasundaram¹, B. W. Higgs¹, Q. Xu², A. Zeevi², M. Reyes-Mugica¹
¹Childrens Hospital of Pittsburgh of UPMC, Pittsburgh, PA, ²University of Pittsburgh Medical Center, Pittsburgh, PA
*Purpose: We have previously reported enhanced B-cell presentation of donor antigen during early T-cell mediated liver transplant (LT) rejection.*Methods: To characterize B-cell related immunological mechanisms…
2022 American Transplant Congress
Direct Central Ambulatory Venoarterial Extracorporeal Membrane Oxygenation and Double Lung Transplantation without Graft Reduction with Extreme Mediastinal Shift
A. Gorton¹, S. Keshavamurthy²
¹Cardiothoracic Surgery, University of Kentucky, Lexington, KY, ²University of Kentucky, Lexington, KY
*Purpose: Double Lung transplantation in the presence of extreme mediastinal shift can be technically challenging due to donor sizing and recipient factors.*Methods: We present the…
2022 American Transplant Congress
The Ontario Anatomic Kidney Score (OAKS) : Quantitative Macroscopic Assessment versus Histological Grading in Pre-transplant Evaluation of Donor Kidneys
J. Mello Offerni¹, D. Matty², H. Abed³, P. Roshanov⁴, A. Sener¹, P. Luke¹
¹Urology, Western University, London, ON, Canada, ²Undergraduate Medical Education, Western University, Schulich School of Medicine & Dentistry, London, ON, Canada, ³Division of Urology, Department of Surgery, Schulich School of Medicine & Dentistry, Western University, London, ON, Canada, ⁴Division of Nephrology, Department of Internal Medicine, Schulich School of Medicine & Dentistry, Western University, London, ON, Canada
*Purpose: Quantitative gross assessment of a kidney has not been used to influence the evaluation to utilize a kidney for transplantation. The Ontario Anatomic Kidney…