Am J Transplant, Volume 22, Suppl 3 Archives - Page 90 of 190 - ATC Abstracts

2022 American Transplant Congress
Dynamic Risk Prediction of Kidney Graft Failure After Deceased Donor Transplant
D. G. Hu¹, H. Thiessen Philbrook¹, S. Mohan², I. Hall³, M. Doshi⁴, K. F. Kerr⁵, C. R. Parikh¹
¹Johns Hopkins University, Baltimore, MD, ²Columbia University Medical Center, New York, NY, ³University of Utah, Salt Lake City, UT, ⁴University of Michigan, Ann Arbor, MI, ⁵University of Washington, Seattle, WA
*Purpose: Identifying kidney transplant recipients at risk of graft failure allows for early intervention in clinical care. We developed a dynamic risk prediction model based…
2022 American Transplant Congress
18 Month Review of Liver Acuity Circles Allocation
J. Foutz¹, S. Noreen¹, M. Cafarella¹, A. Wilk¹, J. Trotter², S. Biggins³, J. Pomposelli⁴
¹United Network for Organ Sharing, Richmond, VA, ²Baylor University Medical Center, Dallas, TX, ³University of Washington, Seattle, WA, ⁴University of Colorado, Aurora, CO
*Purpose: Acuity circles (AC) allocation was implemented on 2/4/2020 with a goal of removing DSA and region from liver allocation and broadening the distribution of…
2022 American Transplant Congress
Increased Waitlist Mortality in Pediatric Liver Transplant Candidates with Greater Distance from Transplant Center
C. X. Qin, T. Ishaque, S. M. Frey, A. B. Massie, A. M. Cameron, D. L. Segev, E. A. King
Johns Hopkins University School of Medicine, Baltimore, MD
*Purpose: Greater distance from transplant center in adult liver transplant (LT) candidates is associated with increased waitlist mortality. Pediatric LT candidates have higher waitlist mortality…
2022 American Transplant Congress
25 Years of a Standardized Living Donor (LD) Intestinal Transplant Technique – What Has Been Achieved?
R. Gruessner¹, A. C. Gruessner²
¹SUNY Downstate Medical Center, Brooklyn, NY, ²SUNY Downstate Medical Center, Brooklyn, MA
*Purpose: The indication for intestinal transplantation (ITX) is irreversible intestinal failure with dependence on total parenteral nutrition (TPN). Most intestinal transplants are from deceased donors…
2022 American Transplant Congress
Perfusate Metabolites and Association with Pump Perfusion and Allograft Failure
R. X. Liu¹, N. Koyawala², H. T. Philbrook², I. Hall³, P. Reese⁴, S. Mohan⁵, M. Doshi⁶, C. Parikh¹
¹Johns Hopkins University School of Medicine, Baltimore, MD, ²Department of Medicine, Division of Nephrology, Johns Hopkins University School of Medicine, Baltimore, MD, ³University of Utah School of Medicine, Salt Lake City, UT, ⁴University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, ⁵University of Columbia Vagelos College of Physicians & Surgeons, New York, NY, ⁶University of Michigan, Ann Arbor, MI
*Purpose: While hypothermic machine perfusion (HMP) is associated with improved kidney graft viability, the exact biological mechanisms underlying this association are unknown. The goal of…
2022 American Transplant Congress
T Cell Overexpression of PD-1 Increases Treg Suppressive Function via an ICOS-Dependent Mechanism
T. J. Borges¹, N. Murakami², I. T. Lape¹, R. B. Gassen¹, K. Liu¹, L. V. Riella¹
¹Surgery, Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA, ²Transplantation Research Center, Brigham and Women's Hospital, Boston, MA
*Purpose: The PD-1: PD-L1 signaling has inhibitory properties and is a potential therapeutic target in transplantation. We have previously demonstrated that overexpression of PD-1 on…
2022 American Transplant Congress
Dynamic Changes in Titer and Specificity Autoantibodies in Chronic Bm12 to B/6 Kidney Rejection
I. Sayin¹, D. Yin¹, D. Ghosh², M. Clark², A. Chong¹
¹Department of Surgery, University of Chicago, Chicago, IL, ²Department of Medicine, University of Chicago, Chicago, IL
*Purpose: Loss of autoreactive B cell tolerance and production of non-HLA autoantibodies have been observed in patients undergoing chronic rejection, however, how autoreactive B cells…
2022 American Transplant Congress
Molecular Characterization of the Plasma Secretome in Pediatric Liver Transplantation (pLTx) Identified Cytokine/Chemokine Signatures Potentially Linked to Beneficial Immunosuppressive Regimes (IS) and Recovery
E. Chichelnitskiy¹, L. Ruhl², I. Goldschmidt³, A. Karch⁴, L. Antiga⁵, D. Debray⁶, L. Hierro⁷, D. Kelly⁸, V. McLin⁹, E. Nicastro¹⁰, J. Pawlowska¹¹, P. Czubkowski¹¹, R. Mikolajczyk¹², U. Baumann¹³, C. Falk¹⁴
¹Institute of Transplant Immunology, Hannover Medical School (MHH), Hannover, Germany, ²Institute of Transplant Immunology, MHH, Hannover, Germany, ³Division of Pediatric Gastroenterology and Hepatology, MHH; European Paediatric Liver Transplantation Network, Hannover, Germany, ⁴Research Group Epidemiological and Statistical Methods, Helmholtz Centre for Infection Research, Braunschweig; German Center for Infection Research, TTU-IICH Hannover;Institute for Epidemiology and Social Medicine, University of Münster, Münster, Germany, ⁵Ospedali Riuniti di Bergamo, Bergamo, Italy, ⁶Hôpital Necker-Enfants Malades, Paris, France, ⁷Hospital Infantil Universitario La Paz, Madrid, Spain, ⁸Birmingham Childrens Hosp, Birmingham, United Kingdom, ⁹Service Spécialités Pédiatriques, Genève, Switzerland, ¹⁰Pediatric Hepatology, Gastroenterology and Transplantation, Hospital Papa Giovanni XXIII, Bergamo, Italy, ¹¹Gastroenterology, Hepatology, Nutritional Disorders and Pediatrics, The Children’s Memorial Health Institute, Warsaw, Poland, ¹²Institute of Medical Epidemiology, Biostatistics and Medical Informatics, University of Halle; German Center for Infection Research, TTU-IICH Hannover; MHH, Halle, Germany, ¹³Division of Pediatric Gastroenterology and Hepatology, MHH; Birmingham Children’s Hospital, UK, Hannover, Germany, ¹⁴Institute of Transplant Immunology, MHH; German Center for Infection Research, TTU-IICH, Hannover, Germany
*Purpose: In the European multicentre “ChilSFree” study we aimed to characterize longitudinal dynamics of soluble immune mediators during the first year after pLTx.*Methods: Using Luminex-based…
2022 American Transplant Congress
Antibody-Mediated Allograft Rejection is Associated with an Increase in Peripheral Differentiated Cd28-cd8+ T Cells – Analyses of a Cohort of 1032 Kidney Transplant Recipients
H. L. Mai¹, N. Degauque¹, S. Le Bot¹, M. Rimbert¹, K. Renaudin¹, R. Danger¹, F. Le Borgne², C. Kerleau¹, F. Delbos³, M. Giral¹, S. Brouard¹
¹UMR 1064 - CRTI, INSERM - CHU de Nantes, Nantes, France, ²UMR 1046 - SPHERE, INSERM - IDBC-A2COM, Nantes, France, ³Etablissement Français du Sang (EFS) - CHU de Nantes, Nantes, France
*Purpose: CD28-CD8+ T cells represent a differentiated CD8+ T cell subset that is found to be increased in various conditions associated with chronic antigenic stimulation…
2022 American Transplant Congress
Use of Everolimus and Reduced Calcineurin Inhibitors in Bk Nephropathy: Insights from Follow-Up and Surveillance Biopsies
Z. S. Zaky, M. Spinner, B. Stephany
Cleveland Clinic, Cleveland, OH
*Purpose: BK virus-associated nephropathy (BKVAN) is a clinically important entity that results in an allograft loss in kidney transplant recipients (KTRs). Mammalian target of rapamycin…