Am J Transplant, Volume 22, Suppl 3 Archives - Page 68 of 190 - ATC Abstracts

2022 American Transplant Congress
A Novel Immunosuppressive Compound (79-6) That Targets Bcl6 Prevents the Humoral Alloresponse
R. Kraaijeveld, D. A. Hesselink, C. C. Baan
Internal medicine - Nephrology and Transplantation, Erasmus Medical Center, Rotterdam, Netherlands
*Purpose: BCL6, is a transcription factor involved in B cell activation and differentiation. BCL6-expressing B cells play a crucial role in the development and maintenance…
2022 American Transplant Congress
A Randomized Assessment of a County-Wide, Primary Care Provider (PCP) Office-Based Intervention for Organ Donor Registration
M. McCabe¹, K. M. Dokus², N. J. Ryan², A. James², P. Veazie¹, M. Orloff², S. McIntosh², R. Kashyap²
¹University of Rochester School of Medicine and Dentistry, Rochester, NY, ²University of Rochester Medical Center, Rochester, NY
*Purpose: The number of individuals awaiting organ transplantation continues to rise steadily, with the current waitlist totaling over 100,000 patients. However, rates of organ donor…
2022 American Transplant Congress
Reduction of Rabbit Anti-Thymocyte Globulin Dosing for Induction of Kidney Transplant During the COVID-19 Pandemic
C. Burrelli¹, S. Gundling¹, D. Ecabert¹, R. Powell¹, A. Padiyar¹, K. Andreoni¹, K. Chavin², A. Bixby¹
¹University Hospitals Cleveland Medical Center, Cleveland, OH, ²University Hospitals Cleveland Medical Center / Case Western Reserve, Cleveland, OH
*Purpose: Rabbit anti-thymocyte globulin (rATG) is a polyclonal antibody utilized for induction immunosuppression in high immunologic risk kidney transplant recipients. However, the optimal total dose…
2022 American Transplant Congress
Outcomes in Lung Transplant Recipients Switched from Tacrolimus to Cyclosporine Due to Hyperammonemia Early Post-Transplantation
S. Goyal, J. Lyons, P. Stracener, B. Bemiss
Loyola University Medical Center, Chicago, IL
*Purpose: Assess the impact of switching from tacrolimus to cyclosporine due to hyperammonemia on outcomes at 1-year post-lung transplant.*Methods: A retrospective review of lung transplant…
2022 American Transplant Congress
Late Liver Turn Downs: The Utilization and Impact of the Expedited Process
K. Gauntt¹, C. Martinez¹, R. Hunter¹, J. Prinz², K. Shutterly³, D. Brockmeier⁴
¹United Network For Organ Sharing, Richmond, VA, ²Donor Alliance, Denver, CO, ³Center for Organ Recovery and Education, Pittsburgh, PA, ⁴Mid-America Transplant, St. Louis, MO
*Purpose: There is belief that the discard rates are higher for organs turned down late in the recovery process. The expedited liver (LI) pathway, allows…
2022 American Transplant Congress
Immunometabolism of Regulatory T Cells Enhanced by Lipid Nanoparticles
J. S. Rink¹, Y. Sambandam², J. He², J. Mathew³, J. R. Leventhal⁴, C. S. Thaxton⁵
¹Department of Medicine, Division of Hematology/ Oncology, Northwestern University, Chicago, IL, ²Comprehensive Transplant Center, Northwestern University, Chicago, IL, ³Northwestern University, Chicago, IL, ⁴Surgery, Northwestern Medicine, Chicago, IL, ⁵Department of Urology, Northwestern University, Chicago, IL
*Purpose: Human regulatory T cell (Treg) metabolism is highly dependent upon a number of factors, including cholesterol obtained from circulating lipoproteins. We have developed high-density…
2022 American Transplant Congress
The Role of the Gut Microbiota in Pain Interference Before and After Kidney Transplantation: A Pilot Study
M. B. Lockwood¹, H. DeVon², M. Maienschein-Cline¹, G. Chlipala¹, M. Samra³, A. Lichvar⁴, S. Green⁵
¹University of Illinois at Chicago, Chicago, IL, ²UCLA, Los Angeles, CA, ³Loyola University Medical Center, Chicago, IL, ⁴UCSD, San Diego, CA, ⁵Rush University, Chicago, IL
*Purpose: To characterize relationships between differential relative abundances of taxonomy (genus level) of the gut microbiome and pain interference before and after living donor kidney…
2022 American Transplant Congress
Immunoglobulin M (IgM) Inhibits Replication of SARS-CoV-2 In Vero E6 Cells In Vitro and Delays Disease in K18-hACE2 Mice Infected with SARSCoV-2 In Vivo
P. Chhabra¹, B. Mann², M. Ma¹, S. Feldman³, K. L. Brayman¹
¹Department of Surgery, University of Virginia Health System, Charlottesville, VA, ²Department of Infectious Diseases, University of Virginia Health System, Charlottesville, VA, ³Center for Comparative Medicine, University of Virginia Health System, Charlottesville, VA
*Purpose: To determine if IgM has a direct effect in preventing SARS-CoV-2 replication in Vero E6 cells, and delaying or preventing disease in infected K18-hACE2…
2022 American Transplant Congress
Spectrum of Pre-Transplant Esophagram Abnormalities and Association with Long-Term Outcomes
I. Lill¹, D. Lovin², A. C. Lawrence², M. Mohanka², J. Joerns², S. Bollineni², I. L. Timofte², V. Kaza², M. Wait³, F. Torres², A. Banga²
¹University of Texas - Southwestern, Dallas, TX, ²Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, University of Texas - Southwestern, Dallas, TX, ³Cardiovascular & Thoracic Surgery, University of Texas - Southwestern, Dallas, TX
*Purpose: To determine the frequency and type of esophageal abnormalities on screening esophagram during the pre-transplant evaluation and evaluate the association of these abnormalities on…
2022 American Transplant Congress
Variability In Plasma Donor-derived Cell-free DNA Levels With CLAD More Than 5-years After Lung Transplantation: Pilot Data
D. Levine¹, D. Ross²
¹Department of Medicine, University of Texas, San Antonio, San Antonio, TX, ²Natera, Inc., Ausin, TX
*Purpose: Donor-derived cell-free DNA (dd-cfDNA) has been clinically validated for detection of acute rejection (AR) in lung transplant (LT) although studies have typically focused on…