ATC Abstracts

American Transplant Congress abstracts

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  • 2022 American Transplant Congress

    Mass Cytometry Reveals Single-cell Kinetics Of Cytotoxic Lymphocyte Evolution In Cmv-infected Renal Transplant Patients

    K. Ishiyama1, J. Arakawa-Hoyt1, O. Aguilar1, T. Sigdel1, S. Tamaki1, J. Babdor1, M. Spitzer1, E. Reed2, M. Sarwal3, L. Lanier1

    1UCSF, San Francisco, CA, 2Univ of California LA, Los Angeles, CA, 3University of California San Francisco, San Francisco, CA

    *Purpose: Cytomegalovirus (CMV) infection is associated with graft rejection in renal transplantation. Memory-like NK cells expressing NKG2C and lacking FcεRIγ are established during CMV infection.*Methods:…
  • 2022 American Transplant Congress

    Cold Stress-Induced Ferroptosis in Liver Sinusoidal Endothelial Cells Deteriorates Liver Transplant Outcomes

    H. Kojima, H. Hirao, K. Kadono, T. Ito, K. J. Dery, F. Kaldas, J. Kupiec-Weglinski

    UCLA Medical Center, Los Angeles, CA

    *Purpose: While hepatocytes are affected by ischemia-reperfusion injury (IRI) especially under normothermic stress, liver sinusoidal endothelial cells (LSECs) are particularly vulnerable to cold storage-induced IR-insult.…
  • 2022 American Transplant Congress

    An Analysis of Serological Response and Infection Outcomes Following Oxford Astra-Zeneca (azd1222) and Pfizer-Biontech (mRNA BNT162b2) SARS-CoV-2 Vaccines in Kidney and Pancreas Transplant Patients

    A. Asderakis1, U. Khalid1, G. Koimtzis1, M. Ponsford2, L. Szabó1, L. Grant2, S. Jolles2, I. Humphreys3

    1Cardiff Transplant Unit, University Hospital of Wales, Cardiff, United Kingdom, 2Immunodeficiency Centre for Wales, University Hospital of Wales, Cardiff, United Kingdom, 3Division of Infection and Immunity, Cardiff University, Cardiff, United Kingdom

    *Purpose: SARS-CoV-2 is associated with high mortality among transplant recipients. This study aims to compare the humoral responses between the Oxford-Astra-Zeneca(AZ) and BNT162b2(Pfizer-BioNTech) vaccines in…
  • 2022 American Transplant Congress

    Pulsatile Kidney Perfusion Improves Survival and Graft Function in High Acuity Combined Liver Kidney Transplant (CLKT) Recipients

    T. Liu1, G. Panayotova2, F. Paterno3, A. Amin2, L. Brown4, J. Guarrera5, K. Lunsford6

    1Surgery, Rutgers New Jersey Medical School, Newark, NJ, 2Division of Transplant and Hepatobiliary Surgery, Rutgers New Jersey Medical School, Newark, NJ, 3Rutgers State University of New Jersey, Montclair, NJ, 4Rutgers New Jersey Medical School, Morris Plains, NJ, 5Surgery/ Transplant, Rutgers New Jersey Medical School, Newark, NJ, 6Rutgers New Jersey Medical School, Newark, NJ

    *Purpose: Due to underlying renal dysfunction, CLKT recipients tend to have higher medical acuity at baseline resulting in a higher likelihood of post-operative complications and…
  • 2022 American Transplant Congress

    Stabilization of Cell-Cell Junctions Improves Outcomes in an Ex-Vivo Porcine Renal Ischemia-Reperfusion Injury Culture Model

    L. Plumblee1, K. Patel2, L. Langerude3, Z. Tu3, D. Nord4, T. Beduschi3, S. Nadig5, C. Atkinson6

    1MUSC College of Medicine, Gainesville, FL, 2University of Virgina, Charlottesville, VA, 3University of Florida, Gaineville, FL, 4Division of Pulmonary, Critical Care, and Sleep Medicine, University of Florida, Gainesville, FL, 5Northwestern University, Charleston, SC, 6Pulmonary Medicine, University of Florida, Gainesville, FL

    *Purpose: Renal transplant is an accepted therapy for end-stage renal failure. Chronic transplant dysfunction remains the leading cause of long-term graft loss and is, in…
  • 2022 American Transplant Congress

    Characterizing Outcomes of Patients with Colorectal Liver Metastases (CRLM) Undergoing Liver Transplantation (LT) Evaluation

    E. Takoushian1, E. Brandon1, B. Samstein2, K. Halazun2

    1Liver Transplantation, New York Presbyterian Weill Cornell, New York, NY, 2Weill Cornell Medical Center, New York, NY

    *Purpose: LT is a novel therapy for patients with unresectable CRLM. 5 year survival using LT appears to be significantly better than systemic chemotherapy in…
  • 2022 American Transplant Congress

    Use of Targeted T-Cell Therapy (Posoleucel) for the Treatment of Epstein-Barr Virus Associated Leiomyosarcoma in an Adult Kidney Transplant Recipient: A Case Report

    R. Saranu1, S. Nikiforow2, V. Jo3, H. So2, P. Stowe2, S. Tripathi1, F. Cardarelli4, A. Chandraker1

    1Renal Division, Brigham and Women's Hospital, Boston, MA, 2Dana Farber Cancer Institute, Boston, MA, 3Pathology, Brigham and Women's Hospital, Boston, MA, 4Allovir, Cambridge, MA

    *Purpose: Epstein-Barr virus (EBV)-associated leiomyosarcomas (EBV+LMS) are neoplasms rarely seen in solid organ transplant (SOT) recipients and currently lack effective treatment options. We present a…
  • 2022 American Transplant Congress

    Clinical Significance of the Living Kidney Donor Profile Index in Living Kidney Donors for Predicting of Post-Transplant Outcome: Korean Organ Transplantation Registry

    J. Kim1, D. Kim1, S. Yoon1, S. Kang1, J. Kim1, H. Hwang1, K. Jeong1, H. Ko2, C. Jung3, D. Kim4, Y. Kim5, J. Yang6, C. Ahn7

    1Department of Nephrology, Kyung Hee University hospital, Seoul, Korea, Republic of, 2Department of Surgery, College of Medicine, Kyung Hee University, Seoul, Korea, Republic of, 3Department of Transplantation and Vascular Surgery, Korea University Anam Hospital, Seoul, Korea, Republic of, 4Department of Surgery, Yonsei University Wonju College of Medicine, Wonju Severance Christian Hospital, Wonju, Korea, Republic of, 5Department of Internal Medicine, Inje University Busan Paik Hospital, Busan, Korea, Republic of, 6Department of Surgery, Seoul National University Hospital, Seoul, Korea, Republic of, 7Department of Nephrology, Seoul National University Hospital, Seoul, Korea, Republic of

    *Purpose: According to recent reports, a risk index for living donor kidney transplantation (LDKT) such as the Kidney donor profile index (KDPI), a non-invasive method…
  • 2022 American Transplant Congress

    Placement of COVID Positive Organs: An Early Analysis

    A. M. Hawxby, R. Ketcham, J. P. Orlowski, R. Squires, C. Hostetler

    Organ Recovery, LifeShare Transplant Donor Services of Oklahoma, Oklahoma City, OK

    *Purpose: Until recently, donor COVID positivity was seen as a contraindication for donation or transplantation. Our OPO has recently adopted a practice in which organs…
  • 2022 American Transplant Congress

    Early versus Delayed Cytomegalovirus Prophylaxis in High-Risk Kidney Transplant Recipients

    A. Hutchins1, M. Leick2, M. Keck2, J. S. McMullen2

    1Pharmacy, Houston Methodist Hospital, Houston, TX, 2Pharmacy, Nebraska Medicine, Omaha, NE

    *Purpose: The purpose of this study is to determine the effect of delaying cytomegalovirus (CMV) prophylaxis to day of discharge or post-operative day (POD) 7…
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