ATC Abstracts

American Transplant Congress abstracts

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  • 2022 American Transplant Congress

    Neutrophil CEACAM1 Regulates Extracellular Trap Formation via Non-Canonical Inflammasome Signaling and Impacts Liver Transplantation in Mouse and Human

    H. Hirao, H. Kojima, K. Kadono, K. J. Dery, D. G. Farmer, F. M. Kaldas, J. Kupiec-Weglinski

    UCLA, Los Angeles, CA

    *Purpose: Neutrophil extracellular trap (NET) formation relates to various diseases, including sterile inflammation. Although neutrophils express proficient CEACAM1 (CC1, also known as CD66a) long isoform,…
  • 2022 American Transplant Congress

    Lung Transplant Waitlist Outcomes for Blood Group O Candidates After the Expansion of the Primary Allocation Unit in November 2017

    S. Greissman1, M. Anderson2, S. Arcasoy3, A. Dimango3, M. Gabriela3, H. Grewal3, H. Robbins3, L. Shah3, J. Costa3, F. D'Ovidio3, M. Leiva Juarez3, P. Lemaitre3, J. Sonett3, L. Benvenuto3

    1Department of Internal Medicine, New York Presbyterian, New York, NY, 2University of Pennsylvania, Philadelphia, PA, 3Columbia University, New York, NY

    *Purpose: Blood group O is associated with decreased lung transplant rates. Occasionally, blood group donor O lungs are allocated to non-blood group O recipients. Since…
  • 2022 American Transplant Congress

    Broad Panel Genetic Testing for Chronic Kidney Disease in the Transplant Center

    A. Bhalla1, D. Raible2, V. Balaraman1, M. Talwar1

    1James D. Eason Transplant Institute, Methodist University Hospital, Memphis, TN, 2Natera, Inc., Austin, TX

    *Purpose: Genetic testing is an emerging tool for ‌the evaluation of patients with end-stage renal disease (ESRD). In kidney transplantation (KT), testing can identify disease…
  • 2022 American Transplant Congress

    Absolute Quantification of Donor-Derived Cell-Free DNA Does Not Provide Additional Discriminating Power Over Donor-derived Cell-Free DNA Fraction for Detection of Allograft Rejection

    R. Gohh1, S. Jordan2, R. N. Woodward3, K. M. Clark-Langone3, J. Morlan3, B. Silva3, M. Weir4

    1Alpert School of Medicine Brown University, Providence, RI, 2Cedars Sinai Medical Ctr, Los Angeles, CA, 3CareDx, Redwood City, CA, 4University of Maryland School of Medicine, Baltimore, MD

    *Purpose: High level of background cell-free DNA (cfDNA) has been hypothesized as a concern for false negative results in molecular diagnostics for allograft rejection that…
  • 2022 American Transplant Congress

    The Perspective of General Nephrologists Toward Transitions of Care and Management of Patients with Failing Kidney Allografts

    T. Alhamad1, H. Murad1, D. Dadhania2, M. Pavlakis3, S. Parajuli4, B. P. Concepcion5, N. Singh6, N. Murakami7, M. Casey8, M. Ji1, M. Lubetzky9, E. Tantisattamo10, O. Alomar1, A. Faravardeh11, C. Blosser12, A. Basu13, M. Molnar14, G. Gupta15, J. T. Adler16, D. Adey17, K. J. Woodside18, R. Parsons13, K. Lentine19

    1Wash U in St. Louis, Saint Louis, MO, 2Weill Cornell Med, New York, NY, 3Beth Israel, Boston, MA, 4U of Wisconsin, Madison, WI, 5Vanderbilt U, Nashville, TN, 6Northwell Health, Great neck, NY, 7Brigham and Women, Boston, MA, 8MUSC, Charleston, SC, 9Weill Cornell Medicine, New York, NY, 10UCI, Orange, CA, 11SHARP, San Diego, CA, 12U of Washington, Seattle, WA, 13Emory U, Atlanta, GA, 14U of Utah, Salt Lake City, UT, 15VCU, Richmond, VA, 16Surgery, Brigham and Women, Boston, MA, 17UCSF, San Francisco, CA, 18U of Michigan, Ann Arbor, MI, 19Saint Louis U, Saint Louis, MO

    *Purpose: Failing kidney allograft with subsequent return to dialysis is associated with high risk of morbidity and mortality. This project aimed to examine general nephrologist…
  • 2022 American Transplant Congress

    BK Polyomavirus Infection is Not Associated with a Meaningful Increase in Donor-Derived Cell-Free DNA

    J. Fisher1, K. Vieira1, R. Burke2, R. Gohh1, R. Rogers1

    1Warren Alpert Medical School of Brown University, Providence, RI, 2CareDx, Brisbane, CA

    *Purpose: Donor-derived cell-free DNA (dd-cfDNA) is a non-invasive measure of early allograft injury that has been clinically validated as a surveillance tool to detect antibody…
  • 2022 American Transplant Congress

    Tuberculosis (TB) Treatment without Rifampin in Kidney (K) and Kidney-Pancreas (KP) Transplantation (Tx)

    M. V. Radisic1, N. Pujato1, P. M. Bravo1, R. Del Grosso2, M. Hunter2, S. Beltramino3, L. Cornet1, R. Livia Franzini4, A. C. Dotta4, L. Leon4, J. Walther4, P. Uva5, G. Werber3, M. C. Rial4

    1Infectious Diseases, ITAC (Instituto de Trasplante y Alta Complejidad), Ciudad Autonoma de Buenos Aires, Argentina, 2Internal Medicine, ITAC (Instituto de Trasplante y Alta Complejidad), Ciudad Autonoma de Buenos Aires, Argentina, 3Critical Care, ITAC (Instituto de Trasplante y Alta Complejidad), Ciudad Autonoma de Buenos Aires, Argentina, 4Kidney Transplantation, ITAC (Instituto de Trasplante y Alta Complejidad), Ciudad Autonoma de Buenos Aires, Argentina, 5Kidney Pancreas Transplantation, ITAC (Instituto de Trasplante y Alta Complejidad), Ciudad Autonoma de Buenos Aires, Argentina

    *Purpose: TB is a diagnostic and therapeutic challenge in K/KP Tx. Pharmacokinetic interaction between rifampin (RFP) and mTOR /calcineurin inhibitors (CNI) led to use of…
  • 2022 American Transplant Congress

    Single Dose Alemtuzemab Provides Comparable Rejection Free and Infection Free Survival Compared to Double Dose Alemtuzumab. In Comparison to Alemtuzemab, Basiliximab Has Superior Infection Free Graft Survival. Results from a Steroid Sparing Transplant Group

    H. Sharma, A. Odugoudar, B. Devkaran, A. Rao, A. El-Bakry, T. Gunawardhane, D. Ridgway, M. Howse, S. Mehra

    Department of Transplant Surgery, Royal Liverpool University Hospital, Liverpool, United Kingdom

    *Purpose: The present study investigated the short-term biopsy-proven acute rejection rates and viral infection rates amongst our protocol of single-dose Alemtuzemab (Cohort 1) versus double…
  • 2022 American Transplant Congress

    Daratumumab Therapy Achieves Dialysis Independence in Kidney Transplant Recipients with Resistant Proliferative Glomerulonephritis with Monoclonal Immunoglobulin Deposits

    P. Yenebere, R. Daloul

    The Ohio State University, Columbus, OH

    *Purpose: Proliferative glomerulonephritis with monoclonal immunoglobulin deposits (PGNMID) is a unique cause for monoclonal gammopathy of renal significance with overall poor prognosis. Patients are frequently…
  • 2022 American Transplant Congress

    Bystander Suppression: Enhancing the Power of Ex Vivo Expanded Antigen Specific Regulatory Cell Lines

    S. Tripathi1, P. L. Martin-Moreno2, G. J. Kavalam3, B. Schreiber3, A. Wagaa-Gasser1, A. Chandraker4

    1Renal, Brigham and Women's Hospital, Boston, MA, 2Nephrology, Clinica Universidad de Navarra, Ripagaina, Spain, 3Brigham and Women's Hospital, Boston, MA, 4Medicine, Brigham and Women's Hospital, Boston, MA

    *Purpose: The potential of T regulatory cell (Treg) based therapies in transplantation has been demonstrated in various preclinical models. Multiple clinical trials are currently undergoing…
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