Am J Transplant, Volume 22, Suppl 3 Archives - Page 188 of 190 - ATC Abstracts

2022 American Transplant Congress
Controlling Instability at Reperfusion: Another Benefit of Normothermic Machine Perfusion Using OCS Liver
C. S. Hwang¹, C. Shi², M. Patel¹, J. Shah¹, L. DeGregorio¹, S. Hanish¹, Y. Kadakia³, U. Chaudhary³, E. Okoro², S. Cheruku², P. Lahsaei², P. Vagefi¹, M. MacConmara⁴
¹Surgery, University of Texas Southwestern Medical Center, Dallas, TX, ²Anesthesia, University of Texas Southwestern Medical Center, Dallas, TX, ³University of Texas Southwestern Medical Center, Dallas, TX, ⁴TransMedics, Andover, MA
*Purpose: Organ Care System (OCS) Liver is a portable ex-vivo normothermic liver perfusion device recently shown to provide superior donor organ preservation. The impact of…
2022 American Transplant Congress
Vascularized Tracheal Transplantation; A One Year Update
E. M. Genden
Otolaryngology- Head and Neck Surgery, The Icahn School of Medicine at Mount Sinai, New York, NY
*Purpose: In January 2021, we performed the first single stage vascularized tracheal transplantation for reconstruction of a 9.5 cm tracheal airway defect. One year after…
2022 American Transplant Congress
Single Cell Multiomics Reveals Immune Mediators in Acute Cellular Rejection Following Pediatric Liver Transplantation
B. Rocque¹, D. Sarode², A. Barbetta³, P. Singh⁴, C. Goldbeck⁴, C. Weaver⁵, O. Akbari⁴, R. Kohli⁵, J. Emamaullee⁶
¹University of Southern California Keck School of Medicine, Los Angeles, CA, ²Keck School of Medicine of University of Southern California, Pasadena, CA, ³Surgery, abdominal transplat, University of Southern California, Los Angeles, CA, ⁴Keck School of Medicine of USC, Los Angeles, CA, ⁵Childrens Hospital Los Angeles, Los Angeles, CA, ⁶University of Southern California, Los Angeles, CA
*Purpose: Acute cellular rejection (ACR) is a common complication following pediatric liver transplantation with potential negative effects on allograft longevity. Currently, diagnosis and management are…
2022 American Transplant Congress
Absence of DAP12 Expression by Donor Liver-Derived Dendritic Cells Enhances Their Contact with T Cells in Host Secondary Lymphoid Tissue: Implications for Abrogation of MHC-mismatched Liver Transplant Tolerance in Mice
R. Nakano, A. Perez Gutierrez, G. Camirand, D. A. Geller, A. W. Thomson
University of Pittsburgh, Pittsburgh, PA
*Purpose: Multiphoton intravital microscopy is a high-resolution, real-time, fluorescence imaging technique that enables study of interactions between cells in their native, 3-dimensional environment including organ…
2022 American Transplant Congress
Recoverability of Diabetic Nephropathy of Donor Kidney After Kidney Transplantation
K. Lee, J. Park
Samsung Medical Center, Seoul, Korea, Republic of
*Purpose: The natural course of diabetic donors on the outcome of kidney transplantation (KT) is controversial. The aim of this study was to analyze the…
2022 American Transplant Congress
Evolution of Pretransplant Cardiac Risk Factor Burden and Major Adverse Cardiovascular Events in Liver Transplant Recipients Over Time
C. Harrington, P. Levy, E. Cabrera, J. Gao, D. Gregory, C. Padilla, G. Crespo, L. VanWagner
Northwestern Medicine, Chicago, IL
*Purpose: The aim of this study is to evaluate the evolution of MACE and pre-LT cardiac risk factors in LTRs over time.*Methods: This is a…
2022 American Transplant Congress
Development and Validation of a Machine Learning Based Virtual Biopsy System in Kidney Transplant Patients
D. Yoo¹, G. Divard¹, M. Raynaud¹, A. Bentall², M. Stegall³, M. Naesens⁴, I. Batal⁵, S. Coley⁶, J. Gill⁷, M. Mengel⁸, L. Cornell³, M. P. Alexander², T. Coates⁹, C. Legendre¹⁰, P. Reese¹¹, c. lefaucheur¹², O. Aubert¹, A. Loupy¹
¹Paris Transplant Group, Paris, France, ²-, -, AL, ³Mayo Clinic, Rochester, MN, ⁴Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium, ⁵Columbia University Medical Center, Scarsdale, NY, ⁶Columbia University, New York, NY, ⁷University of British Columbia, Vancouver, BC, Canada, ⁸University of Alberta, Edmonton, AB, Canada, ⁹University of Adelaide, Adelaide, Australia, ¹⁰Hopital Necker, Paris, France, ¹¹University of Pennsylvania, Philadelphia, PA, ¹²Hôpital Saint-Louis, Paris, France
*Purpose: In kidney TX, day-zero biopsies are used to assess organ quality and discriminate lesions inherited from the donor or acquired after transplantation. However, many…
2022 American Transplant Congress
Incidence and Outcomes of Fever of Unknown Origin After Kidney Transplant in the Modern Era
M. Jorgenson, S. Parajuli, B. Astor, C. Saddler, J. Smith, D. Mandelbrot
University of Wisconsin Health, Madison, WI
*Purpose: Fever is common in kidney transplant recipients (KTRs). If an etiology is not readily apparent, a patient can be classified as having a fever…
2022 American Transplant Congress
Hepatocyte Notch1 Regulates Autophagy/DR5 Axis and Inhibits Cell Death in Mouse and Human Liver Transplantation
H. Hirao, K. Kadono, H. Kojima, K. J. Dery, D. G. Farmer, F. M. Kaldas, B. Ke, J. Kupiec-Weglinski
UCLA, Los Angeles, CA
*Purpose: Liver ischemia-reperfusion injury (IRI) is a major risk factor of early graft dysfunction and predisposes to rejection in orthotopic liver transplantation (OLT). Although Notch1…
2022 American Transplant Congress
A Novel IL-2 Mutein Selectively Expands Regulatory T Cells and Prolongs Skin Graft Survival
O. Efe¹, T. J. Borges¹, R. B. Gassen¹, L. Morena¹, A. Al Jurdi¹, I. T. Lape¹, G. J. Bobcock², J. C. Madsen¹, L. V. Riella¹
¹Center for Transplantation Sciences, Massachusetts General Hospital, Charlestown, MA, ²Visterra, Inc., Waltham, MA
*Purpose: Promoting immune regulation through expansion of regulatory T cell (Treg) may allow immunosuppression minimization and improve long-term graft outcomes. Low-dose IL-2 is known to…