Am J Transplant, Volume 22, Suppl 3 Archives - Page 16 of 190 - ATC Abstracts

2022 American Transplant Congress
Donor Kidney-Resident Passenger Macrophages Promote CCL8-CCR8 Mediated Early Allograft Inflammation
A. Dangi¹, I. Husain², N. Natesh³, X. Shen³, J. Kwun⁴, X. Luo⁵
¹Medicine, Duke University Medical Center, Durham, NC, ²Duke University Medical Center, Durham, NC, ³Biomedical Engineering, Duke University, Durham, NC, ⁴Duke Transplant Center, Durham, NC, ⁵Duke University School of Medicine, Durham, NC
*Purpose: Early intragraft infiltration of monocytes and macrophages has been associated with acute and chronic allograft rejections. Nevertheless, underlying mechanism remained poorly understood. In the…
2022 American Transplant Congress
Cd80 on Effector T Cell Binds Pd-l1 on Lymphatic Endothelial Cells to Fine Tune Migration
W. Piao¹, V. Saxena¹, L. Li¹, K. Hippen², Y. Zhang², B. Blazar², I. Lape³, L. Riella³, J. Bromberg¹
¹Surgery, University of Maryland, Baltimore, MD, ²University of Minnesota, Minneapolis, MN, ³Harvard Medical School, Boston, MA
*Purpose: Antigen presenting cell (APC) CD80 trans-binds CD28 and CTLA4 on T cells, boosting or inhibiting immunity, respectively. CD80 has another ligand, Programmed Death-1 Ligand…
2022 American Transplant Congress
An Interim Report on a Prospective Randomized Trial of Extended-Release Tacrolimus in Liver Transplantation with Anti-Thymocyte Induction in a Steroid Free Protocol
R. A. Helmick, S. Naik, C. Eymard, J. Eason, J. Vanatta
James D. Eason Transplant Institute at Methodist University Hospital and University of Tennessee Health Science Center, Memphis, TN
*Purpose: Our study hypothesis was that once daily dosing of extended-release tacrolimus (ERT) would be a safe and effective immunosuppression (IS) with the potential to…
2022 American Transplant Congress
Genotype-Guided Voriconazole Prescribing in Lung Transplant Recipients
C. Luo, R. G. Nador, R. D. Levy, J. Swiston, C. Bergeron, N. Partovi
Vancouver General Hospital, Vancouver, BC, Canada
*Purpose: Voriconazole (VRC) is the treatment of choice for Aspergillus in lung transplant recipients. VRC undergoes metabolism via CYP2C19, a polymorphic enzyme that has varying…
2022 American Transplant Congress
Xenogeneic Cross-Circulation Supports Ex Vivo Human Livers for 24 Hours
W. K. Wu¹, R. Ukita², Y. J. Patel², I. A. Ziogas³, M. Cortelli², M. Mentz², J. R. Talackine², S. A. Francois², N. L. Cardwell², J. W. Stokes², S. P. Alexopoulos³, M. Bacchetta²
¹Hepatobiliary Surgery and Liver Transplantation; Thoracic Surgery, Vanderbilt University Medical Center, Nashville, TN, ²Thoracic Surgery, Vanderbilt University Medical Center, Nashville, TN, ³Hepatobiliary Surgery and Liver Transplantation, Vanderbilt University Medical Center, Nashville, TN
*Purpose: Despite increasing use of machine perfusion as an organ preservation and rescue technique in liver transplantation, significant organ shortages and waitlist mortality highlight a…
2022 American Transplant Congress
The Cost And Logistical Challenges To Kidney Paired Donation
S. G. Yi¹, V. E. Whittaker², T. B. Dunn³, N. Goldaracena⁴, V. Humphreville⁵, C. Kubal⁶, C. Kuhr⁷, D. Leeser⁸, J. Pomposelli⁹, E. Thomas¹⁰, N. Turgeon¹¹, C. Varma¹², M. Rees¹³, A. K. Mathur¹⁴
¹Houston Methodist Hospital, Houston, TX, ²New York Medical College, Scarsdale, NY, ³University of Pennsylvania, Philadelphia, PA, ⁴Transplant Surgery, University of Virginia Health System, Charlottesville, VA, ⁵University of Minnesota Medical Center, Minneapolis, MN, ⁶Indiana University Hospital, Indianapolis, IN, ⁷Virgina Mason Medical Center, Seattle, WA, ⁸East Carolina Univ Sch of Med, Greenville, NC, ⁹University of Colorado, Aurora, CO, ¹⁰University of Texas Health Science Center at San Antonio, San Antonio, TX, ¹¹Dell Seton Medical Center at The University of Texas, Austin, TX, ¹²St Louis University Hospital, St Louis, MO, ¹³University of Toledo Medical Center, Toledo, OH, ¹⁴Mayo Clinic in Arizona, Phoenix, AZ
*Purpose: Kidney paired donation (KPD) is a strategy for finding compatible pairing for living kidney transplantation (LDKT); however, only a small portion of LDKT continues…
2022 American Transplant Congress
Allocation Based on Acuity Circles Decreases Waiting Time for Liver Transplant Patients
M. H. Kim, K. Sasaki, A. Gallo, T. Pham, M. L. Melcher, S. Busque, C. Esquivel, C. Bonham
Stanford University, Stanford, CA
*Purpose: In February, 2020, UNOS implemented a new liver allocation system incorporating a combination of acuity based on MELD/PELD score and distance from the donor…
2022 American Transplant Congress
Accepting Rejection in Liver Transplant Recipients Requiring Renal Replacement Therapy: A Practice Paradigm
S. Farghaly¹, T. Sparkes¹, B. Masters¹, A. Haririan², N. Jakhete³, R. N. Barth⁴, D. Maluf⁵, S. Freedman¹
¹Pharmacy, University of Maryland Medical Center, Baltimore, MD, ²Nephrology, University of Maryland Medical Center, Baltimore, MD, ³Hepatology, University of Maryland Medical Center, Baltimore, MD, ⁴Transplant Surgery, University of Chicago Medical Center, Chicago, IL, ⁵Transplant Surgery, University of Maryland Medical Center, Baltimore, MD
*Purpose: The purpose of this study is to evaluate rejection outcomes in those requiring renal replacement therapy (RRT) after liver transplant.*Methods: This was a single…
2022 American Transplant Congress
Clinical Relevance of Class II HLA Mismatches in Living Donor Kidney Transplantation
J. Lan¹, M. Kadatz¹, D. Chang¹, R. Liwski², E. Wagner², P. Campbell², J. Gill¹, J. Gill¹
¹University of British Columbia, Vancouver, BC, Canada, ²On behalf of Canadian HLA Advisory Committee, Ottawa, ON, Canada
*Purpose: The benefit of class II HLA matching is primarily shown in deceased donor kidney transplantation. The objective of this study was to determine the…
2022 American Transplant Congress
Outcomes of Post-Operative Plasmapheresis in African American Kidney Transplant Recipients with High Panel Reactive Antibodies – A Single Center Experience
B. Valdepenas, M. Campara, J. Benken, C. Muran, D. Pierce, K. Heagler, P. DiCocco, J. Almario Alvarez, M. Spaggiari, I. Tang, I. Tzvetanov, E. Benedetti
University of Illinois at Chicago, Chicago, IL
*Purpose: African American (AA) kidney transplant (KTx) candidates are disadvantaged given increased immunologic risk and longer waitlist time. The purpose of this study was to…