Am J Transplant, Volume 22, Suppl 3 Archives - Page 16 of 190 - ATC Abstracts

2022 American Transplant Congress
Post-Acute Sequelae of Sars-Cov-2 Infection in Solid Organ Transplant Recipients
S. Alasfar¹, T. Chiang¹, A. J. Snyder², M. T. Ou¹, B. Boyarsky¹, A. T. Abedon¹, J. L. Alejo¹, W. Cochran¹, J. M. Garonzik-Wang³, D. C. Brennan¹, T. Vannorsdall¹, D. L. Segev¹, R. K. Avery¹
¹Johns Hopkins University, Baltimore, MD, ²University of Washington, Seattle, WA, ³University of Wisconsin, Madison, WI
*Purpose: Post-acute sequelae of SARS-CoV-2 infection (PASC) is an increasingly recognized phenomenon manifested by long lasting cognitive, mental, and physical symptoms. We aimed to estimate…
2022 American Transplant Congress
Donor-Derived IL-33 Plays a Critical Role in Lung Allograft Acceptance
Y. Guo¹, Z. Mei¹, M. Khalil¹, D. Li¹, A. Banerjee¹, A. Gelman², D. Kreisel², A. Krupnick¹
¹Department of Surgery, University of Maryland, Baltimore, Baltimore, MD, ²Washington University School of Medicine in St Louis, Saint Louis, MO
*Purpose: IL-33 is considered an alarmin secreted in response to tissue damage. While it is elaborated by the lung allograft as part of ischemia-reperfusion injury…
2022 American Transplant Congress
RNA-Sequencing Analysis of Kidney Allografts Reveal Heightened NK Cell Activity in Chronic Active Antibody-Mediated Rejection
Y. Shah, E. Varma, S. Rahim, C. Li, C. Snopkowski, C. Hughes, D. M. Dadhania, S. Salvatore, S. V. Seshan, O. Elemento, M. Suthanthiran, T. Muthukumar
Weill Cornell Medicine, New York, NY
*Purpose: The role of NK cells is increasingly recognized in chronic active antibody mediated rejection (caABMR) of the kidney allograft. Treatment of caABMR is challenging…
2022 American Transplant Congress
Desensitization Protocol to Prevent Severe Oliguric Antibody-Mediated Rejection
H. Ishida¹, K. Unagami¹, T. Kamzawa¹, K. Omoto¹, H. Shimizu¹, K. Tanabe²
¹Tokyo Womens, Tokyo 162-8666, Japan, ²Tokyo Women's Medical University, Tokyo, Japan
*Purpose: Antibody-mediated rejection in a case with a positive crossmatch test can be severe and result in sudden onset of oliguria and sometimes, anuria, leading…
2022 American Transplant Congress
Does ABO/HLA Matching Matter in Uterus Transplantation?
L. Johannesson¹, M. Askar¹, A. Wall², G. Testa¹
¹Baylor University Medical Center, Dallas, TX, ²Baylor Scott and White Dallas, Dallas, TX
*Purpose: Uterus transplantation (UTx) is the most commonly performed vascular composite allograft and is rapidly becoming an accepted treatment for absolute uterine-factor infertility (AUFI). There…
2022 American Transplant Congress
Donor-Specific Hyporesponsiveness Following Kidney Transplantation is Explained by Progressive Loss of Donor-Reactive Polyfunctional Cd4+ Effector Memory T Cells
A. C. van der List, N. H. Litjens, M. Klepper, F. Prevoo, M. G. Betjes
Internal Medicine, Erasmus MC, Rotterdam, Netherlands
*Purpose: After kidney transplantation, donor-specific hyporesponsiveness (DSH) develops which is defined as a lowered response of alloreactive T cells to donor antigen while retaining response…
2022 American Transplant Congress
Center-Level Variability in DDLT Rate Before and After the Implementation of MMaT/250 Score
T. Ishaque, J. Beckett, B. King, J. G. Wang, D. Segev, A. Massie
Johns Hopkins Medical Institutions, Baltimore, MD
*Purpose: In 02/2020, OPTN replaced DSA/regional boundaries with acuity circles and substituted exception scores for individual patients to median-MELD-at-transplant within 250 nautical miles of a…
2022 American Transplant Congress
Landscape of Attitudes Towards Living Kidney Donation During the SARS-CoV-2 Pandemic in the United States: Results of a Public Opinion Survey
K. Kaplow¹, J. Ruck¹, A. Thomas¹, D. Warren¹, D. Segev¹, C. Corlett², J. Sinacore³, M. Levan¹
¹Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, ²Brand Planning LLC, Williamsburg, VA, ³National Kidney Registry, Babylon, NY
*Purpose: Solid organ transplantation decreased during the SARS-CoV-2 pandemic largely due to temporary shutdowns. The pandemic revealed significant gaps in medical knowledge among the public;…
2022 American Transplant Congress
Pharmacogenomic Dosing in Kidney Transplant Patients Converted from Tacrolimus Immediate Release to Tacrolimus Extended Release (Envarsus XR®)
K. D. Belfield¹, K. J. Armstrong², D. Malhotra³, G. F. Girone¹
¹Department of Pharmacy, Yale New Haven Hospital, New Haven, CT, ²Department of Pharmacy, Hospital of Central Connecticut, New Britain, CT, ³Section of Nephrology, Yale School of Medicine, New Haven, CT
*Purpose: When converting from tacrolimus (tac) immediate release (tacIR) to tac extended release (Envarsus XR; tacXR), the package insert (PI) recommends 80% of the tacIR…
2022 American Transplant Congress
Humoral and Cellular Immune Response to a Third Dose Of SARS-CoV-2 Vaccine in Kidney Transplant Recipients on Belatacept
J. Mitchell¹, J. Alejo¹, T. P. Chiang¹, J. N. Blankson¹, A. H. Karaba¹, B. Woldemeskel¹, C. Garliss¹, A. Chang¹, A. Abedon¹, R. K. Avery¹, A. Tobian¹, A. B. Massie¹, J. Garonzik-Wang², D. L. Segev¹, W. Werbel¹
¹Johns Hopkins University, Baltimore, MD, ²University of Wisconsin, Madison, WI
*Purpose: Kidney transplant recipients taking belatacept (KTR-B) have poor immune response to two-dose SARS-CoV-2 vaccination. We sought to characterize the impact of an additional vaccine…