2022 American Transplant Congress
130 Totally Robotic Donor Hepatectomy: Reproducibility Of A Standardized Technique Across 2 Specialized Centers
*Purpose: Robotic surgery is emerging as a feasible though complex technique to enable minimally-invasive donor hepatectomy.*Methods: First multicenter prospective study on 130 consecutive totally robotic…2022 American Transplant Congress
Disruption of B Cell Population is Associated with Increased Infections in Pediatric Transplant Recipients
Pediatrics, UCSD Rady Children's, San Diego, CA
*Purpose: Solid-organ transplant recipients are placed on long-term immunosuppression, preventing graft rejection but increasing the risk of infection. Pediatric transplant recipients are at increased risk…2022 American Transplant Congress
Kidney Transplant Alone Recipients with Advanced Liver Disease Have Similar Outcomes to Those without Advanced Liver Disease
Icahn School of Medicine at Mount Sinai, New York, NY
*Purpose: The prevalence of concomitant liver disease (CLD) in patients with ESRD is reported to be 7-40%. Safety of kidney transplant alone (KTA) in those…2022 American Transplant Congress
Cost-Effectiveness of Transplanting Hepatitis C Donor Hearts Into Hepatitis C Uninfected Recipients
*Purpose: To examine the clinical impact and cost-effectiveness of hepatitis C viremic (HCV+) heart organ donation in the United States.*Methods: We used a microsimulation model…2022 American Transplant Congress
Poor Tolerability of CFTR Modulator Therapy in Lung Transplant Recipients
*Purpose: Elexacaftor/tezacaftor/ivacaftor (ELX/TEZ/IVA) is a highly effective therapy for cystic fibrosis (CF) with potential benefits in lung transplant recipients (LTRs) for extrapulmonary CF manifestations, however…2022 American Transplant Congress
Identification of a Unique and Mechanistic Urinary Cell mRNA Signature in Tolerant Kidney Transplant Recipients Conditioned with FCR001 Facilitating Cells
*Purpose: Urinary cell mRNA profiling is a powerful tool to interrogate kidney allograft status and can diagnose and anticipate acute rejection in kidney allograft recipients.…2022 American Transplant Congress
HCK is a Key Regulator for Macrophage Polarization in Kidney Fibrosis
Icahn School of Medicine at Mount Sinai, New York, NY
*Purpose: Interstitial fibrosis and tubular atrophy (IF/TA) is common histological abnormality in biopsy of kidney transplants. Our previous study from a prospective human kidney transplant…2022 American Transplant Congress
Sting but Not Mtor Signaling Regulates Exogenous Mitochondrion-Induced Endothelial Cell Mitophagy
Duke University School of Medicine, Durham, NC
*Purpose: We have previously demonstrated activation and increasing mitophagy of human endothelial cells (ECs) following exogenous mitochondrion-stimulation. The objectives of this study were to evaluate…2022 American Transplant Congress
Zfyve21 Activates T Cell Intrinsic, Nlrp3 Inflammasomes to Promote Allograft Vasculopathy
*Purpose: Allograft vasculopathy (AV) is a complication of chronic allograft rejection whose underlying mechanism(s) of etiopathogenesis are poorly defined. We examined the role of ZFYVE21,…2022 American Transplant Congress
The New Heart Allocation Policy Has Increased Listing by Exception
*Purpose: The new heart allocation policy (October 2018) expanded the number of listing statuses and established a national review board for exception requests in an…
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