Am J Transplant, Volume 22, Suppl 3 Archives - Page 158 of 190 - ATC Abstracts

2022 American Transplant Congress
EBV+ PTLD Tumor MicroRNAs Detected in Circulating Extracellular Vesicles Are Decreased in Pediatric Transplant Recipients with EBV+ PTLD
A. Sen¹, J. Enriquez¹, M. Rao¹, M. Glass¹, Y. Balachandran¹, S. Syed¹, C. Twist¹, K. Weinberg¹, S. D. Boyd¹, D. Bernstein¹, A. Trickey¹, D. Gratzinger¹, B. Tan¹, M. G. Lapasaran¹, M. A. Robien², M. Brown³, B. Armstrong⁴, M. Sever⁴, D. Desai⁵, G. Mazariegos⁶, C. Chin⁷, T. Fishbein⁸, R. S. Venick⁹, A. Tekin¹⁰, H. Zimmermann¹¹, R. U. Trappe¹², C. O. Esquivel¹, O. M. Martinez¹, S. M. Krams¹
¹Stanford U, Palo Alto, CA, ²NIH, Bethesda, MD, ³NIAID, Bethesda, MD, ⁴Rho, Durham, NC, ⁵UT Southwestern, Dallas, TX, ⁶Pittsburgh U, Pittsburgh, PA, ⁷CCHMC, Cincinnati, OH, ⁸Georgetown U, Washington, DC, ⁹UCLA, LA, CA, ¹⁰Miami U, Miami, FL, ¹¹DIAKO Ev. Diakonie-Krankenhaus, Bremen, Germany, ¹²Charité - Universitätsmedizin, Berlin, Germany
*Purpose: Post-transplant lymphoproliferative disorder (PTLD) is a serious complication of solid organ transplantation. Predisposing factors for PTLD include primary Epstein-Barr virus (EBV) infection in children,…
2022 American Transplant Congress
Long-Term (>1 Year) Rejection Free Graft Survival of Kidney Xenografts with Triple Xenoantigen Knockout and Multiple Human Transgenes in Cynomolgus Monkeys
T. Hirose¹, G. Lassiter¹, D. Ma¹, A. D'Attilio¹, I. Rosales¹, D. Cloonan¹, R. Matheson¹, R. Colvin¹, W. Qin², Y. Kan², J. Layer², R. Anand², V. Paragas², L. Queroz², X. Tan², I. Kohnle², K. Stiede², K. Hall², M. Youd², M. Curtis², J. Markmann¹, T. Kawai¹
¹Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA, ²eGenesis Inc, Cambridge, MA
*Purpose: Pigs with deletion of 3 carbohydrate xenoantigens (triple knock-out, TKO) are expected to be optimal donors for human xenotransplantation. We have previously shown that…
2022 American Transplant Congress
Acute Graft versus Host Disease (AGVHD) Related to Solid Organ Transplant (SOT) – A Fatal Complication
H. Shaikh¹, J. Awosika¹, B. Barakoti¹, B. Hambley¹, C. Alquist²
¹University of Cincinnati Medical Center, Cincinnati, OH, ²Hoxworth Blood Center, Cincinnati, OH
*Purpose: This case series highlights our institution's experience with solid-organ transplant (SOT) associated acute graft versus host disease (aGVHD), a rare and deadly complication of…
2022 American Transplant Congress
Post-Kidney Donation Pregnancy Complications and Long-Term Outcomes
E. F. Palzer¹, E. S. Helgeson¹, M. Evans², D. Vock¹, A. Matas³
¹Biostatistics, University of Minnesota, Minneapolis, MN, ²Clinical and Translational Science Institute, University of Minnesota, Minneapolis, MN, ³Surgery, University of Minnesota Medical School, Minneapolis, MN
*Purpose: In the general population, pregnancy complications are associated with long-term maternal risk. Kidney donors with postdonation pregnancies have increased risk of gestational HTN and…
2022 American Transplant Congress
A Novel Application of SRTR Data to Interrogate the Effects of HLA-DQ Mismatches in Kidney Transplantation
D. Isaacson¹, M. W. Gmeiner², V. Kosmoliaptsis³, H. C. Copley³, J. D. Schold⁴, A. R. Tambur¹
¹Northwestern University, Chicago, IL, ²London School of Economics, London, United Kingdom, ³Cambridge University, Cambridge, United Kingdom, ⁴Cleveland Clinic, Cleveland, OH
*Purpose: Single-center studies demonstrate de-novo HLA-DQ donor-specific antibodies (DSA) are the most common and pathogenic DSA. However, HLA-DQ is not accounted for in many kidney…
2022 American Transplant Congress
Normothermic Machine Perfusion in Liver Transplantation – Seven Year Experience at a Single North American Centre
J. Hefler¹, D. L. Izuierdo¹, G. Meeberg², M. Bral¹, B. Anderson¹, K. Dajani¹, N. Kneteman¹, D. L. Bigam¹, A. Shapiro¹
¹Department of Surgery, University of Alberta, Edmonton, AB, Canada, ²Alberta Health Services, Edmonton, AB, Canada
*Purpose: Machine perfusion for preservation of liver grafts before transplantation has risen in prominence over the past decade. Normothermic machine perfusion (NMP), in particular, has…
2022 American Transplant Congress
Assessment of the Prevalence of Burnout and Well-Being in Solid Organ Transplant Pharmacists
M. Harris¹, N. Pilch², C. Doligalski³, E. Henricksen⁴, J. Melaragno⁵, A. Lichvar⁶
¹Duke University Hospital, Durham, NC, ²Medical University of South Carolina, Charleston, SC, ³University of North Carolina, Chapel Hill, NC, ⁴Stanford Healthcare, Stanford, CA, ⁵University of Rochester, Rochester, NY, ⁶UC San Diego Health, La Jolla, CA
*Purpose: The purpose of this study was to determine the prevalence of burnout and well-being among solid organ transplant pharmacists in the United States.*Methods: A…
2022 American Transplant Congress
Role of Vaccination in the COVID-19 Nationwide Cohort (N3C) of Solid Organ Transplant Recipients
A. J. Vinson¹, A. Anzalone², R. Dai², E. French³, A. Olex³, J. Sun⁴, G. Agarwal⁵, S. Lee⁶, R. B. Mannon⁷
¹Nova Scotia Health Authority, Halifax, NS, Canada, ²University of Nebraska Medical Center, Omaha, NE, ³Wright Center for Clinical and Translational Research, Richmond, VA, ⁴Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, ⁵University of Alabama at Birmingham, Birmingham, AL, ⁶University of Saskatchewan, Regina, SK, Canada, ⁷Medicine, University of Nebraska Medical Center, Omaha, NE
*Purpose: Immunosuppressed solid organ transplant (SOT) patients have been repeatedly challenged in the COVID-19 pandemic with significant morbidities and mortality following infection and a suppressed…
2022 American Transplant Congress
Donor Kidney-Resident Passenger Macrophages Promote CCL8-CCR8 Mediated Early Allograft Inflammation
A. Dangi¹, I. Husain², N. Natesh³, X. Shen³, J. Kwun⁴, X. Luo⁵
¹Medicine, Duke University Medical Center, Durham, NC, ²Duke University Medical Center, Durham, NC, ³Biomedical Engineering, Duke University, Durham, NC, ⁴Duke Transplant Center, Durham, NC, ⁵Duke University School of Medicine, Durham, NC
*Purpose: Early intragraft infiltration of monocytes and macrophages has been associated with acute and chronic allograft rejections. Nevertheless, underlying mechanism remained poorly understood. In the…
2022 American Transplant Congress
Cd80 on Effector T Cell Binds Pd-l1 on Lymphatic Endothelial Cells to Fine Tune Migration
W. Piao¹, V. Saxena¹, L. Li¹, K. Hippen², Y. Zhang², B. Blazar², I. Lape³, L. Riella³, J. Bromberg¹
¹Surgery, University of Maryland, Baltimore, MD, ²University of Minnesota, Minneapolis, MN, ³Harvard Medical School, Boston, MA
*Purpose: Antigen presenting cell (APC) CD80 trans-binds CD28 and CTLA4 on T cells, boosting or inhibiting immunity, respectively. CD80 has another ligand, Programmed Death-1 Ligand…