Am J Transplant, Volume 22, Suppl 3 Archives - Page 152 of 190 - ATC Abstracts

2022 American Transplant Congress
Apheresis of Deceased Donors: A New Source of Mobilized Peripheral Blood Hematopoietic Stem Cells for Transplant Tolerance
R. A. Sosa¹, T. Mone², B. V. Naini¹, D. B. Kohn³, E. F. Reed¹, K. Wheeler², B. Campo-Fernandez³, A. Davila³, D. J. Chaffin⁴, J. DiNorcia⁵, F. M. Kaldas⁵, A. Cohen², E. Lum⁶, J. L. Veale⁷, N. M. Kogut⁷
¹Pathology and Lab Medicine, UCLA, Los Angeles, CA, ²One Legacy, Los Angeles, CA, ³Microbiology, Immunology and Molecular Genetics, UCLA, Los Angeles, CA, ⁴LifeStream Blood Bank, San Bernadino, CA, ⁵Surgery, UCLA, Los Angeles, CA, ⁶Medicine, UCLA, Los Angeles, CA, ⁷Urology, UCLA, Los Angeles, CA
*Purpose: Solid organ transplantation is the therapy of choice for many patients with end-stage organ failure, but recipients must remain on lifelong immune suppression, leaving…
2022 American Transplant Congress
Reduced CD45RA-CCR7- Tregs Subtypes in Highly Sensitised Patients Associates with a Failure to Regulate Memory IFNγ Production in Response to Donor Alloantigens
C. Dudreuilh¹, S. Basu¹, O. Shaw², H. Burton¹, C. Domingo-Vila¹, T. Tree¹, G. Lombardi¹, C. Scotta¹, A. Dorling¹
¹King's College London, London, United Kingdom, ²Viapath Clinical Transplantation Laboratory, Guy's Hospital, London, United Kingdom
*Purpose: Highly sensitised (HS) patients exhibit worse long-term outcomes after kidney transplantation compared to non-sensitised patients. It has been hypothesised that regulatory T cells (Tregs)…
2022 American Transplant Congress
Regulatory T Cell PopulationsMay be Associated with Transplant Outcomes
H. Shin, S. Heo, Y. Kim, N. Lee, Y. Kim, Y. Jung, H. Rim
Internal Medicine, Kosin University College of Medicine,Transplantation Research Institute,Gospel Hospital, Busan, Korea, Republic of
*Purpose: The development of immunosuppressants has enabled remarkable progress in kidney transplantation (KT). However, current immunosuppressants cannot achieve induction of immune tolerance and their nonspecific…
2022 American Transplant Congress
Lung Transplantation For Covid-19: An International Registry
M. G. Ison¹, R. Giris², O. Dias³, R. Vos⁴, J. Magnusson⁵, T. Zangeneh⁶, E. D. Lease⁷, S. Aslam⁸, M. Weder⁹
¹Northwestern University Comprehensive Transplant Center, Chicago, IL, ²Spectrum Health, Grand Rapids, MI, ³Einstein Hospital, Buenos Aires, Argentina, ⁴UZ Leuven, Leuven, Belgium, ⁵Sahlgrenska Transplant Centre, Stockholm, Sweden, ⁶University of Arizona, Tucscon, AZ, ⁷University of Washington, Seattle, WA, ⁸University of California San Diego, San Diego, CA, ⁹University of Virginia, Charlottesville, VA
*Purpose: SARS-CoV-2 can result in a range of infections from asymptomatic disease to progressive COVID-19 and death. In some patients with COVID-19 Lung Disease (C19LD),…
2022 American Transplant Congress
Prospective Study of Preimplantation Biopsy in Deceased Donor Kidney Transplantation (DDKT)
H. Me, M. Smith, C. Jadlowiec, K. Harris, R. Butterfield, H. Khamash, B. G. AbuJawdeh, K. Reddy, R. Heilman
Mayo Clinic, Phoenix, AZ
*Purpose: Our aim was to study the impact of preimplantation biopsy (Bx) findings in selecting kidneys from more marginal donors.*Methods: This is a 2-year prospective…
2022 American Transplant Congress
De-Novo Belatacept Therapy is Associated with an Increased Risk of Invasive CMV Disease After Kidney Transplantation
G. Petrossian¹, J. Ortiz², K. Addonizio¹, A. Hsiao¹, L. Teixeira¹, N. Koizumi³, R. James³, S. Patel⁴, D. Conti², R. Plews²
¹Albany Medical Center, Albany, NY, ²Division of Renal and Pancreatic Transplant Services, Albany Medical Center, Albany, NY, ³George Mason University, Fairfax, VA, ⁴UMC Las Vegas, Las Vegas, NV
*Purpose: To compare the rate of CMV viremia and invasive disease in kidney transplantation patients with a de-novo belatacept (bela) regimen vs. a no-bela maintenance…
2022 American Transplant Congress
Outcomes in Obese Patients with Diabetes Mellitus Type 2 That Received Simultaneous Pancreas and Kidney Transplant
M. Merzkani¹, H. Murad², M. Wang³, V. Hu⁴, M. Ji⁵, Y. Al-Hosni⁴, O. Alzahabi³, M. Zayed³, K. Lentine⁶, J. Wellen⁷, S. Chang⁸, T. Alhamad⁹
¹Washington University, Saint Louis, MO, ²Washington University in St Louis, Chesterfield, MO, ³Washington U, St Louis, MO, ⁴Wash U, St Louis, MO, ⁵Washington University in St. Louis School of Medicine, Saint Louis, MO, ⁶SLU, St Louis, MO, ⁷Washington University School of Medicine, Saint Louis, MO, ⁸Surgery, Washington University School of Medicine, Saint Louis, MO, ⁹Washington University School of Medicine at St. Louis, Saint Louis, MO
*Purpose: Simultaneous pancreas and kidney transplant (SPKT) has excellent outcomes in patients with end stage renal disease secondary to diabetes mellitus type 2 (DMT2). The…
2022 American Transplant Congress
A Cost Effectiveness Analysis of Adherence Promotion Strategies to Improve Rejection Rates in Adolescent Kidney Transplant Patients
C. Varnell¹, K. Rich¹, A. Modi¹, D. Hooper¹, M. Eckman²
¹Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ²University of Cincinnati School of Medicine, Cincinnati, OH
*Purpose: In adolescents with a kidney transplant, non-adherence increases the risk of graft loss. Adherence promotion interventions improve adherence and rejection rates, but perceived cost…
2022 American Transplant Congress
Role of Innate Immunity in Regulating Host Responses to Ischemia and Reperfusion and Allograft Rejection Injury in Vascularized Composite Allotransplantation
S. Han¹, X. Lai², J. Wang¹, L. VanOsdol³, C. Chen¹, J. Mathew¹, J. R. Leventhal⁴, Z. Zhang⁵
¹Northwestern University, Chicago, IL, ²Comprehensive Transplant Center, Microsurgery Core, Northwestern University, Chicago, IL, ³Comprehensive Transplant Center, Northwestern University, Chicago, IL, ⁴Surgery, Northwestern Medicine, Chicago, IL, ⁵Northwestern University Transplant Surgery, Chicago, IL
*Purpose: Vascularized composite tissue allotransplantation (VCA) 's wide application has been impeded by deleterious side-effect of current immunosuppressive regimens. This study is aimed to determine…
2022 American Transplant Congress
Novel Drug Target Identified for Reversal of Renal Tubular Injury
S. Sur, M. Kerwin, S. Pineda, M. Sarwal
UCSF, San Francisco, CA
*Purpose: Understanding the unique susceptibility of the human kidney tubule to oxidative cell stress and to identify compounds to support reversal of renal tubular damage.*Methods:…