ATC Abstracts

American Transplant Congress abstracts

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  • 2022 American Transplant Congress

    Normothermic Machine Perfusion of the Liver Supports Protein Translation and Mitochondrial Function While Reducing Protein Degradation and Metabolic Imbalance: A Proteomics Study

    L. Lo Faro1, A. Thorne2, H. Huang3, P. Charles3, M. Kaisar1, S. Davis3, F. Dengu1, S. Shaheed1, J. Mulvey1, R. Fischer3, D. Nasralla4, B. Kessler3, H. Leuvenink2, P. Friend1, R. Ploeg1

    1Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom, 2University Medical Center Groningen, Groningen, Netherlands, 3Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom, 4Royal Free London NHS Foundation Trust, London, United Kingdom

    *Purpose: Liver preservation by normothermic machine perfusion (NMP) involves perfusion of the graft with oxygenated blood and nutrients. The NMP Liver trial by the Consortium…
  • 2022 American Transplant Congress

    Multicenter Effort Assessing the Effects of COVID Infection and Vaccination on HLA Antibodies in Waitlisted Patients with ESRD

    G. R. Roll1, M. Cooper2, H. Gebel3, K. M. Hitchman4, M. Hobeika5, J. Houp6, M. Kamoun7, J. Killian8, J. Kim9, V. Kumar10, M. Levine11, T. Lunow-Luke1, R. Parsons12, D. Ranch13, P. Stock14, S. Yi15, R. Rajalingam16

    1UCSF Medical Center, San Francisco, CA, 2MedStar Georgetown Transplant Institute, Washington, DC, 3Emory University Hospital, Atlanta, GA, 4Pathology and Laboratory Medicine, University of Texas Health San Antonio, San Antonio, TX, 5Houston Methodist, Houston, TX, 6University of Alabama, Birmingham, AL, 7Hospital Univ of Pennsylvania, Philadelphia, PA, 8University of Alabama at Birmingham, Birmingham, AL, 9Surgery, Keck Medicine of USC, Los Angeles, CA, 10University of Alabama at Birmingham Hospital, Birmingham, AL, 11University of Pennsylvania, Philadelphia, Pe, 12Emory University School of Medicine, Atlanta, GA, 13UT Health San Antonio, San Antonio, TX, 14Univ of California-San Francisco, San Francisco, CA, 15Houston Methodist Hospital, Houston, TX, 16Immunogenetics and Transplantation Laboratory (ITL), San Francisco, CA

    *Purpose: Although rare, infection and vaccination have been reported to result in human leukocyte antibodies (HLA). We analyzed the effect of SARS-CoV2 infection, or COVID-19…
  • 2022 American Transplant Congress

    Portal Vein Thrombosis and DCD Liver Transplantation: Dangerous Combination or Clinical Opportunity?

    E. Calderon1, Y. Chang2, P. Lu1, A. M. Durant3, D. Derakshani4, M. L. Anderson4, E. R. Luque Villa2, C. Jadlowiec2, K. Reddy2, A. Moss2, A. K. Mathur2

    1General Surgery, Mayo Clinic, Phoenix, AZ, 2Mayo Clinic, Phoenix, AZ, 3Urology, Mayo Clinic, Phoenix, AZ, 4Mayo Clinic Alix School of Medicine, Phoenix, AZ

    *Purpose: Individually, recipient portal vein thrombosis (PVT) and donation after circulatory death (DCD) allografts are associated with a higher risk of poor deceased donor liver…
  • 2022 American Transplant Congress

    Assessing Safety of Using ECMO-Supported Donors in Abdominal Transplantation

    P. J. Altshuler1, A. P. Shah1, J. M. Glorioso1, W. R. Maley1, A. M. Frank1, C. B. Ramirez1, H. Dang1, S. West2, R. Hasz, Jr.2, A. S. Bodzin1

    1Department of Surgery, Thomas Jefferson University, Philadelphia, PA, 2Gift Of Life Donor Program, Philadelphia, PA

    *Purpose: Organ donors supported by extracorporeal membrane oxygenation (ECMO) are historically considered high-risk and are judiciously utilized. Here we explore the safety of using organs…
  • 2022 American Transplant Congress

    Increased Survival Benefit Amongst Highest Priority Candidates Undergoing Heart Transplant Following the New Us Heart Allocation System

    S. Tolmie1, W. Parker2

    1Pritzker School of Medicine, University of Chicago, Chicago, IL, 2Department of Medicine, Section of Pulmonary and Critical Care Medicine, University of Chicago, Chicago, IL

    *Purpose: A key policy change in the new US heart allocation system was splitting the previous highest status (1A) into statuses 1, 2, and 3…
  • 2022 American Transplant Congress

    Novel Avenue of Allograft Monitoring: Direct Measurement of Donor-Derived Extracellular Vesicles in Human Plasma

    W. W. Woud, D. A. Hesselink, M. J. Hoogduijn, C. C. Baan, K. Boer

    Internal Medicine, Erasmus MC Transplant Institute, Rotterdam, Netherlands

    *Purpose: Extracellular Vesicles (EV) - regarded as “snapshots” of their cell of origin - represent promising liquid biomarkers to monitor allograft function post transplantation. Recently,…
  • 2022 American Transplant Congress

    T Cell-Specific CEACAM1 Alleviates Posttransplant Liver Injury via TIM-3 Inhibitory Regulation

    H. Kojima, H. Hirao, K. Kadono, T. Ito, K. J. Dery, F. Kaldas, J. Kupiec-Weglinski

    UCLA Medical Center, Los Angeles, CA

    *Purpose: Carcinoembryonic antigen cell adhesion molecule 1 (CEACAM1; CC1), a recently discovered ligand for T cell immunoglobulin domain and mucin domain-3 (TIM-3) on activated T…
  • 2022 American Transplant Congress

    Recurrence of Membranous Nephropathy After Kidney Transplantation – TANGO Consortium

    F. Hullekes1, A. Uffing1, L. Riella1, P. Cravedi2

    1Harvard Medical School, Boston, MA, 2Mount Sinai, New York, NY

    *Purpose: Membranous nephropathy (MN) is a leading cause of nephrotic syndrome in adults. Several breakthroughs in recent decades, including the identification of anti-PLA2R Abs, aided…
  • 2022 American Transplant Congress

    Derivation of a Cardiac Risk Index for Use in Liver Transplantation for Non-Alcoholic Steatohepatitis

    P. Levy, C. Harrington, E. Cabrera, J. Gao, D. Gregory, C. Padilla, G. Crespo, L. VanWagner

    Northwestern Memorial Hospital, Chicago, IL

    *Purpose: Cardiovascular events (CVEs) are the most common cause of early mortality after liver transplant (LT), and LT candidates with non-alcoholic steatohepatitis (NASH) are at…
  • 2022 American Transplant Congress

    Conversion of Tacrolimus Immediate Release to LCP Tacrolimus in Obese Kidney Transplant Recipients

    J. Newman, N. Patel, S. Patel, T. Sprague, E. Andrade, N. Rao, F. Bartlett, D. DuBay, V. Rohan, M. Casey, D. Taber

    MUSC, Charleston, SC

    *Purpose: Data describing the safety, efficacy and conversion ratio of tacrolimus immediate release (IR) to LCP-tacrolimus (LCP) in obese patients (BMI > 30) is lacking.…
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