Am J Transplant, Volume 22, Suppl 3 Archives - Page 123 of 190 - ATC Abstracts

2022 American Transplant Congress
Cd137 on Host Dendritic Cells Fine-Tunes the Intesity of Donor T Cells in Systemic Alloinmmune Responses
S. Park¹, H. Cho², B. Kwon³, J. Lee⁴, H. Park¹, J. Park⁴, K. Park⁴, K. Yoo⁴
¹Department of Surgery, University of Ulsan College of Medicine, Ulsan, Korea, Republic of, ²University of Ulsan College of Medicine, Ulsan, Korea, Republic of, ³School of Biological Sciences, University of Ulsan, Ulsan, Korea, Republic of, ⁴Department of Internal Medicine, University of Ulsan College of Medicine, Ulsan, Korea, Republic of
*Purpose: CD137 is a potent costimulatory receptor for CD8+ T cells but it also regulates dendritic cells (DCs) to suppress immune responses. In this study,…
2022 American Transplant Congress
Selective CD28 Blockade Impacts T Cell Differentiation During Hematopoietic Reconstitution Following Lymphodepletion
J. Habib, D. Liu, R. L. Crepeau, M. E. Wagener, M. L. Ford
Emory University, Atlanta, GA
*Purpose: Costimulation blockade targeting the CD28 pathway provides improved long-term transplant survival without the nephrotoxicity of calcineurin inhibitors. However, treatment with the CTLA-4Ig fusion protein…
2022 American Transplant Congress
Survival Comparison of Simultaneous Pancreas-Kidney Transplant with Pancreas After Living-Donor Kidney Transplant by Wait Time and Organ Quality
G. R. Lyden¹, E. S. Helgeson², E. B. Finger³, A. J. Matas³, J. J. Snyder⁴, D. M. Vock²
¹Scientific Registry of Transplant Recipients, Hennepin Healthcare Research Institute; Division of Biostatistics, University of Minnesota, Mpls, MN, ²Div Biostatistics U MN, Mpls, MN, ³Dept Surg U MN, Mpls, MN, ⁴Hennepin Healthcare Research Institute, Mpls, MN
*Purpose: The survival benefit of simultaneous pancreas-kidney (SPK) compared to pancreas after living-donor kidney (PALK) transplant is controversial. Wait times for SPK and donor risk…
2022 American Transplant Congress
Secular Trends in Development of ESRD Following Liver Transplant
J. M. Ruck¹, L. Zeiser¹, A. Massie², D. Segev³, E. King¹
¹Johns Hopkins University School of Medicine, Baltimore, MD, ²Johns Hopkins School of Medicine, Baltimore, MD, ³Johns Hopkins University, Baltimore, MD
*Purpose: End-stage renal disease (ESRD) post-liver transplant (LT) is associated with increased mortality, but ESRD incidence and risk factors in LT recipients (LTRs) remain poorly…
2022 American Transplant Congress
Antibody Response to Sars- Cov -2 Mrna Vaccine in Kidney Transplant Recipients
R. Mohamed Abdul Rahman, M. Alkadi, E. Abuhelaiqa, M. Jarman, A. Nauman, O. Fituri, M. Asim, A. Hamad, H. Tohid, P. Coyle, L. Abu Raddad, H. Al-Malki
Nephrology, Hamad Medical Corporation, Doha, Qatar
*Purpose: Kidney transplant recipients are vulnerable to develop severe form of COVID19 Infection. Although severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mRNA vaccine has significantly…
2022 American Transplant Congress
Complex Donor Transfer and Organ Procurement Organization Collaboration to Reduce Ischemia Time in Combined Face and Bilateral Hand Transplant
J. Trilles¹, D. Boczar¹, B. F. Chaya¹, Z. P. Berman¹, G. K. Diep¹, R. Rodriguez Colon¹, D. J. Ceradini¹, E. D. Rodriguez¹, B. E. Gelb²
¹Hansjörg Wyss Department of Plastic Surgery, NYU Langone Health, New York, NY, ²Transplant Institute, NYU Langone Health, New York, NY
*Purpose: We present a complex donor transfer protocol that places the donor at the recipient hospital prior to allograft procurement in order to reduce ischemia…
2022 American Transplant Congress
High Resolution Typing Can Improve Accuracy and Sensitivity of the Virtual Crossmatch for Sensitized Patients – A Single Center’s Experience
C. MarElia-Bennett¹, V. Rohan², K. Twombley³, O. Moussa¹
¹Pathology & Laboratory Medicine, Medical University of South Carolina, Charleston, SC, ²Surgery, Medical University of South Carolina, Charleston, SC, ³Medical University of South Carolina, Charleston, SC
*Purpose: The introduction of solid phase assays has significantly enhanced our ability to execute virtual crossmatches (VXMs). However, this method is not without its shortcomings.…
2022 American Transplant Congress
Identification of Highly-Effective Donor-Reactive CD4⁺CD8α^lo T Cells in CTLA4Ig-Treated Renal Allograft Recipient Monkeys
M. Kubo, K. Sasaki, L. Lu, V. Vujevich, A. Thomson, M. Ezzelarab
Department of Surgery, Thomas E. Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA
*Purpose: Potent CD4+CD8αlo effector T cells have been reported in transplant (tx) patients. . We evaluated the incidence and function of CD4+CD8αloT cells in renal…
2022 American Transplant Congress
Impact Of Antifungal Prophylaxis Discontinuation On Immunosuppression In Lung Transplant Recipients
R. Huntsman, K. Neuhaus
Pharmacy, Cleveland Clinic, Cleveland, OH
*Purpose: The purpose of this study is to characterize the impact of antifungal discontinuation on immunosuppressant levels and incidence of acute rejection and fungal infections…
2022 American Transplant Congress
Impact Of Nirmatrelvir-Ritonavir On Tacrolimus Concentrations
S. Fredrick¹, B. Wise², L. Bowman², D. DeWolfe¹, J. Taylor¹, J. Melaragno¹
¹University of Rochester Medical Center, Rochester, NY, ²Tampa General Hospital, Tampa, FL
*Purpose: Ritonavir (RTV), a component of the oral antiviral agent nirmatrelvir-RTV (Paxlovid) for COVID-19 infection, increases tacrolimus concentrations through strong competitive inhibition of gastrointestinal and…