Am J Transplant, Volume 22, Suppl 3 Archives - Page 105 of 190 - ATC Abstracts

2022 American Transplant Congress
Pre-Transplant Evaluation of Patients Undergoing Combined Heart-Liver Transplantation and Correlation with Explant Pathology
A. Shingina¹, J. N. Menachem¹, S. Brown¹, I. A. Ziogas², W. K. Wu³, M. J. Izzy⁴, J. Liang¹, K. Washington¹, S. Alexopoulos⁵
¹Vanderbilt University Medical Center, Nashville, TN, ²Division of Hepatobiliary Surgery and Liver Transplantation, Vanderbilt University Medical Center, Nashville, TN, ³Thoracic Surgery; Hepatobiliary Surgery and Liver Transplantation, Vanderbilt University Medical Center, Nashville, TN, ⁴GI and Hepatology, Vanderbilt University Medical Center, Nashville, TN, ⁵Vanderbilt Medical Center, Nashville, TN
*Purpose: Fontan-associated liver disease (FALD) is a well-described complication of Fontan physiology. More patients with failing Fontan are being evaluated for heart transplant and evidence-based…
2022 American Transplant Congress
Organ Care System Use in Liver Transplantation Shifts Preservation-Reperfusion Injury in Time and Space
A. J. Demetris, M. A. Wood-Trageser, D. Lesniak, -. The PROTECT Investigators
Department of Transplant Pathology, University of Pittsburgh, Pittsburgh, PA
*Purpose: Liver allograft ischemia-reperfusion injury (IRI) causes early allograft dysfunction (EAD). The TransMedics Organ Care System (OCS) PROTECT trial for liver transplantation (NCT02522871) revealed that…
2022 American Transplant Congress
Desensitization Using Costimulatory Blockade and Bortezomib to Prevent DSA Formation and Rejection in Reconstructive Transplantation
B. Oh, F. Messner, Y. Guo, G. Brandacher
Johns Hopkins University School of Medicine, Baltimore, MD
*Purpose: Sensitization in form of donor-specific antibodies (DSA) and subsequent antibody-mediated rejection constitute some of the greatest risk factors for allograft rejection and long-term graft…
2022 American Transplant Congress
RNA Sequencing Profiling of Pretransplant Blood Identified Variant Allele Specific Expression of Leukocyte Immunoglobulin-Like Receptors (LILRs) Genes Associated with Graft Loss in Kidney Transplant Recipients
Z. Sun¹, Z. Yi¹, Z. Zhang¹, P. Cravedi¹, M. Menon², B. Murphy¹, S. Chen³, W. Zhang¹
¹Icahn School of Medicine at Mount Sinai, New York City, NY, ²Yale University School of Medicine, New Heaven, CT, ³Methodist Hospital, Houston, TX
*Purpose: The RNA sequencing has the possibility of detecting overall gene expression as well as allele-specific expression. Here, we reported a study of genome-wide allele…
2022 American Transplant Congress
Aquaporin 4 is a Mediator of Essential Dendritic Cell Functions
M. Nicosia¹, A. M. Beavers¹, Y. Yamamoto¹, T. Thompson², T. Zindrick², A. Valujskikh¹
¹Inflammation and Immunity, Cleveland Clinic, Lerner Research Institute, Cleveland, OH, ²Aeromics, Cleveland, OH
*Purpose: Aquaporins are a family of transmembrane water channels implicated in a broad range of physiological functions. We previously reported that Aquaporin 4 (AQP4) is…
2022 American Transplant Congress
A Pathway for Establishing Etiology of Kidney Failure: An Academic Transplant Center’s Experience with a Broad Kidney Gene Panel
R. Sodhi¹, K. Brossart², A. Desai¹, D. J. Arwindekar¹, H. Tabriziani², S. Akkina¹
¹Loyola University Medical Center, Maywood, IL, ²Natera, Inc., Austin, TX
*Purpose: Assessing genetic causes of kidney failure can inform pre-transplant decision making and may improve post-transplant outcomes. Here we describe an academic transplant center’s experience…
2022 American Transplant Congress
Fibrinolysis Shutdown Subtype of Early Allograft Dysfunction Represents the Predominant Cohort of Patients with Graft Failure Following Liver Transplantation
H. B. Moore¹, T. L. Nydam², M. Adams³, T. Ferrell¹, I. Rodriguez⁴, D. Yoeli¹, R. Choudhury¹, J. Pomposelli¹, E. A. Pomfret¹
¹University of Colorado, Aurora, CO, ²Univeristy of Colorado, Aurora, CO, ³Childrens Hospital Colorado, Aurora, CO, ⁴University of Colorado Anschutz Medical Campus, Aurora, CO
*Purpose: Early allograft dysfunction (EAD) is associated with an increased rate of graft failure in liver transplantation (LT), but a mechanism remains unclear. Recent experience…
2022 American Transplant Congress
A Machine Learning Model for Predicting Antibody Response to 2-Dose Sars-cov-2 MRNA Vaccine Series in Transplant Recipients
J. L. Alejo¹, J. Mitchell¹, T. Chiang¹, A. Abedon¹, W. Werbel¹, R. Avery¹, A. Tobian¹, A. Massie¹, J. Garonzik-Wang², D. Segev¹, S. Bae¹
¹JHU, Baltimore, MD, ²U of Wisconsin, Madison, WI
*Purpose: Understanding risk factors for impaired vaccine responses can guide strategies for testing, additional dose recommendations, and vaccine schedules to provide improved protection in solid…
2022 American Transplant Congress
Current State of Use of Hepatitis C Viremic Donor Organs in Negative Recipients in the United States: A National Survey
K. Ryland¹, K. Hattori², J. Steinbrink³, N. Theodoropoulos⁴, M. Ison⁵
¹Mayo Clinic, Jacksonville, FL, ²Duke university hospital, Durham, NC, ³Duke University, Durham, NC, ⁴University of Massachusetts Medical School, Worcester, MA, ⁵Northwestern University Comprehensive Transplant Center, Chicago, IL
*Purpose: Since the advent of direct-acting antiviral (DAA) therapy, use of hepatitis C (HCV) viremic donor organs in HCV negative recipients has become more common.…
2022 American Transplant Congress
Tracking of Donor Reactive T Cell Clones Can Be Used to Diagnose or Even Predict Kidney Transplant Rejection
J. M. Mathew¹, Y. Sambandam¹, M. Kandpal¹, J. He¹, G. Perottino¹, B. Banbury², P. Fields², L. Gallon¹, J. R. Leventhal¹
¹Northwestern University, Chicago, IL, ²Adaptive Biotechnologies, Seattle, WA
*Purpose: Transplant (Tx) rejection currently requires an invasive biopsy for diagnosis. We have tested if serial quantitation of donor reactive T cell clones (DRTC) can…