Am J Transplant, Volume 22, Suppl 3 Archives - Page 104 of 190 - ATC Abstracts

2022 American Transplant Congress
The Ties That Transplant: The Social Network Determinants of the Living Kidney Donor Relationship Distribution
J. Daw
Sociology & Criminology, The Pennsylvania State University, University Park, PA
*Purpose: To describe and explain the distribution of social relationships of living kidney donors to kidney transplant recipients.*Methods: Using an original dataset of transplant candidates…
2022 American Transplant Congress
Impact of Biliary Reconstruction on Tacrolimus Absorption in Pediatric Liver Transplant
M. Chandran¹, D. Yoeli¹, A. Sater², M. Adams¹, F. Karrer¹
¹Children's Hospital Colorado, Aurora, CO, ²University of Colorado, Aurora, CO
*Purpose: Tacrolimus (FK506) oral bioavailability in pediatric liver transplant recipients (LTR) is poor. Enteral FK506 is primarily absorbed in the small intestine and subject to…
2022 American Transplant Congress
Lipid Metabolism Profile of Human Kidneys During Ex Vivo Normothermic Perfusion
J. Yu, I. Palma, S. Adams, J. Sageshima, P. Than, R. Perez
UC Davis Medical Center, Sacramento, CA
*Purpose: The kidney is a highly metabolic organ and lipids are an important energy source. In this study, we examined the lipid profiles of discarded…
2022 American Transplant Congress
Adoptive Transfer OfMesenchymal Stem Cells Activates Hedgehog/SMO/Gli1 Signaling And Inhibits STING-mediated Innate Immune Response In Liver Transplant Inflammatory Injury
D. Xu¹, X. Qu¹, Y. Tian¹, M. Sheng¹, Y. Lin¹, Y. Zhan¹, F. M. Kaldas¹, R. W. Busuttil¹, D. G. Farmer¹, J. W. Kupiec-Weglinski¹, Q. Xia², B. Ke¹
¹Surgery, Dumont - UCLA Transplant Ctr, Los Angeles, CA, ²Liver Surgery, Shanghai Jiaotong University School of Medicine, Shanghai, China
*Purpose: The stimulator of interferon genes (STING) pathway has been recognized as a crucial signaling cascade of the innate immune system. Activation of the Hedgehog…
2022 American Transplant Congress
Apheresis of Deceased Donors: A New Source of Mobilized Peripheral Blood Hematopoietic Stem Cells for Transplant Tolerance
R. A. Sosa¹, T. Mone², B. V. Naini¹, D. B. Kohn³, E. F. Reed¹, K. Wheeler², B. Campo-Fernandez³, A. Davila³, D. J. Chaffin⁴, J. DiNorcia⁵, F. M. Kaldas⁵, A. Cohen², E. Lum⁶, J. L. Veale⁷, N. M. Kogut⁷
¹Pathology and Lab Medicine, UCLA, Los Angeles, CA, ²One Legacy, Los Angeles, CA, ³Microbiology, Immunology and Molecular Genetics, UCLA, Los Angeles, CA, ⁴LifeStream Blood Bank, San Bernadino, CA, ⁵Surgery, UCLA, Los Angeles, CA, ⁶Medicine, UCLA, Los Angeles, CA, ⁷Urology, UCLA, Los Angeles, CA
*Purpose: Solid organ transplantation is the therapy of choice for many patients with end-stage organ failure, but recipients must remain on lifelong immune suppression, leaving…
2022 American Transplant Congress
Reduced CD45RA-CCR7- Tregs Subtypes in Highly Sensitised Patients Associates with a Failure to Regulate Memory IFNγ Production in Response to Donor Alloantigens
C. Dudreuilh¹, S. Basu¹, O. Shaw², H. Burton¹, C. Domingo-Vila¹, T. Tree¹, G. Lombardi¹, C. Scotta¹, A. Dorling¹
¹King's College London, London, United Kingdom, ²Viapath Clinical Transplantation Laboratory, Guy's Hospital, London, United Kingdom
*Purpose: Highly sensitised (HS) patients exhibit worse long-term outcomes after kidney transplantation compared to non-sensitised patients. It has been hypothesised that regulatory T cells (Tregs)…
2022 American Transplant Congress
Regulatory T Cell PopulationsMay be Associated with Transplant Outcomes
H. Shin, S. Heo, Y. Kim, N. Lee, Y. Kim, Y. Jung, H. Rim
Internal Medicine, Kosin University College of Medicine,Transplantation Research Institute,Gospel Hospital, Busan, Korea, Republic of
*Purpose: The development of immunosuppressants has enabled remarkable progress in kidney transplantation (KT). However, current immunosuppressants cannot achieve induction of immune tolerance and their nonspecific…
2022 American Transplant Congress
Lung Transplantation For Covid-19: An International Registry
M. G. Ison¹, R. Giris², O. Dias³, R. Vos⁴, J. Magnusson⁵, T. Zangeneh⁶, E. D. Lease⁷, S. Aslam⁸, M. Weder⁹
¹Northwestern University Comprehensive Transplant Center, Chicago, IL, ²Spectrum Health, Grand Rapids, MI, ³Einstein Hospital, Buenos Aires, Argentina, ⁴UZ Leuven, Leuven, Belgium, ⁵Sahlgrenska Transplant Centre, Stockholm, Sweden, ⁶University of Arizona, Tucscon, AZ, ⁷University of Washington, Seattle, WA, ⁸University of California San Diego, San Diego, CA, ⁹University of Virginia, Charlottesville, VA
*Purpose: SARS-CoV-2 can result in a range of infections from asymptomatic disease to progressive COVID-19 and death. In some patients with COVID-19 Lung Disease (C19LD),…
2022 American Transplant Congress
Prospective Study of Preimplantation Biopsy in Deceased Donor Kidney Transplantation (DDKT)
H. Me, M. Smith, C. Jadlowiec, K. Harris, R. Butterfield, H. Khamash, B. G. AbuJawdeh, K. Reddy, R. Heilman
Mayo Clinic, Phoenix, AZ
*Purpose: Our aim was to study the impact of preimplantation biopsy (Bx) findings in selecting kidneys from more marginal donors.*Methods: This is a 2-year prospective…
2022 American Transplant Congress
De-Novo Belatacept Therapy is Associated with an Increased Risk of Invasive CMV Disease After Kidney Transplantation
G. Petrossian¹, J. Ortiz², K. Addonizio¹, A. Hsiao¹, L. Teixeira¹, N. Koizumi³, R. James³, S. Patel⁴, D. Conti², R. Plews²
¹Albany Medical Center, Albany, NY, ²Division of Renal and Pancreatic Transplant Services, Albany Medical Center, Albany, NY, ³George Mason University, Fairfax, VA, ⁴UMC Las Vegas, Las Vegas, NV
*Purpose: To compare the rate of CMV viremia and invasive disease in kidney transplantation patients with a de-novo belatacept (bela) regimen vs. a no-bela maintenance…