Am J Transplant, Volume 22, Suppl 3 Archives - Page 104 of 190 - ATC Abstracts

2022 American Transplant Congress
Characteristics of OPOs with Increased Education Spending, 2013-2018
J. Roberts¹, J. L. Bragg-Gresham², T. Peters³, F. McCormick⁴
¹University of California-San Francisco, San Francisco, CA, ²University of Michigan, Ann Arbor, MI, ³University of Florida, Jacksonville, FL, ⁴Bank of America (former), Walnut Creek, CA
*Purpose: OPO spending on education would be expected to increase donor registration and increase the number of donors. Using data from multiple sources, we examined…
2022 American Transplant Congress
Simultaneous Lung and Kidney Transplant in a Young Patient with COVID-19
M. Bitar¹, J. G. Youssef², S. Yau², A. Goodarzi², G. Youssef³
¹Houston Methodist Academic Pulmonary Medicine, Houston Methodist Hospital, Houston, TX, ²Houston Methodist Pulmonary Transplant Center, Houston Methodist Hospital, Houston, TX, ³Department of Lymphoma and Myeloma, MD Anderson Cancer Center, Houston, TX
*Purpose: Lung transplant is the last resort for COVID-19 refractory ARDS. Dual organ transplant is seen as a relative contraindication at many institutions. We describe…
2022 American Transplant Congress
Years Of Life Gained Through Organ Transplantation From Donors Deceased From Drug Overdose
A. M. Hébert, A. L. Hill
Institute for Computational Medicine, Johns Hopkins University, Baltimore, MD
*Purpose: The worsening opioid crisis in the United States has increased the availability of organs from donors who died of drug overdoses. The goal of…
2022 American Transplant Congress
Treg Crosstalk with Both Tumor and Lymphatic Cells Promotes Metastasis Through Lta1b2-ltbr Signaling
W. Piao¹, R. S. Oakes², C. M. Jewell², J. Bromberg¹
¹Surgery, University of Maryland, Baltimore, MD, ²University of Maryland, College Park, MD
*Purpose: Lymphotoxin (LT) α1β2 high expressing Tregs are essential for immune tolerance although inhibiting antitumor immunity. Lymphatic endothelial cells (LEC) express the LT beta-receptor (LTβR),…
2022 American Transplant Congress
First-in-human Study Of Lis1, A Novel Glyco-humanized Anti-lymphocyte Swine Polyclonal Antibody, In Kidney Transplantation: Safety And Efficacy
J. Slatinska¹, B. Vanhove², M. Kolarova¹, F. Shneiker², J. Rousse², C. Galli³, J. Bach⁴, E. Cozzi⁵, J. Soulillou⁶, O. Duvaux², O. Viklicky¹
¹Institute for Clinical and Experimental Medicine, Prague, Czech Republic, ²Xenothera, Nantes, France, ³Laboratorio di Tecnologie della Riproduzione, Cremone, Italy, ⁴IECM, Immunoendocrinology, USC1383, Oniris, INRAE, Nantes, France, ⁵Transplantation Immunology Unit, Padua University Hospital, Padova, Italy, ⁶Nantes Universités, Nantes, France
*Purpose: to assess safety, T cell depletion, PK/PD and determine the therapeutic dose of LIS1, a purified anti-lymphocyte glyco-humanized polyclonal swine IgG, derived by immunizing…
2022 American Transplant Congress
Clazakizumab® (anti-il-6) Desensitization in Highly-HLA Sensitized Patients Awaiting Kidney Transplant (nct03380962): Long-Term Follow Up
A. Vo¹, J. Tang¹, N. Ammerman¹, E. Huang¹, X. Zhang², M. Haas³, A. Peng¹, R. Najjar¹, S. Williamson¹, C. Meyers¹, S. Sethi¹, K. Lim¹, M. Gillespie¹, N. Badash¹, S. Jordan¹
¹Comprehensive Transplant Center, Cedars Sinai Medical Ctr, Los Angeles, CA, ²HLA Laboratory, Cedars Sinai Medical Ctr, Los Angeles, CA, ³Pathology, Cedars Sinai Medical Ctr, Los Angeles, CA
*Purpose: IL-6 is a cytokine critical for B-cell activation and IgG production. Clazakizumab (CSL Behring LLC) is a humanized monoclonal aimed at the cytokine IL-6.…
2022 American Transplant Congress
Intraoperative Kinetics of Pro-Inflammatory Markers and Delayed-Graft Function During Kidney Transplantation
P. A. Wadsworth, H. L. Stevenson, M. L. Kueht
University of Texas Medical Branch, Galveston, TX
*Purpose: Detailed molecular changes associated with allograft reperfusion have been poorly defined and current methods of predicting delayed graft function (DGF) after kidney transplantation are…
2022 American Transplant Congress
Survival Benefit of Preemptive Simultaneous Pancreas Kidney Transplantation
E. Montagud-Marrahi¹, E. Cuadrado-Payán¹, E. Hermida¹, D. Cucchiari¹, I. Revuelta¹, J. Del Risco-Zevallos¹, J. Casals¹, N. Esforzado¹, F. Cofan¹, F. Oppenheimer¹, V. Torregrosa¹, J. Ferrer², A. J. Amor³, E. Esmatjes¹, M. Ramirez-Bajo⁴, M. Musquera⁵, B. Bayés¹, J. Campistol¹, F. Diekmann¹, P. Ventura-Aguiar¹
¹Nephrology and Kidney Transplantation Department, Hospital Clínic of Barcelona, Barcelona, Spain, ²Hepatobiliopancreatic and Liver Transplant Department, Hospital Clínic of Barcelona, Barcelona, Spain, ³Diabetes Unit. Endocrinology and Nutrition Department, Hospital Clínic of Barcelona, Barcelona, Spain, ⁴Laboratori Experimental de Nefrologia I Trasplantament (LENIT), Fundació Clínic per a la Recerca, Hospital Clínic of Barcelona, Barcelona, Spain, ⁵Urology Department, Hospital Clínic of Barcelona, Barcelona, Spain
*Purpose: Diabetes mellitus is a well-established risk factor for morbidity and mortality among patients on dialysis, but the evidence regarding the benefits of performing preemptive…
2022 American Transplant Congress
Financial Impact of a Culturally Sensitive Hispanic Kidney Transplant Program
J. Caicedo¹, A. Wang², A. Mathur³, R. Ruiz⁴, E. J. Gordon¹
¹Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL, ²Center for Health Services and Outcomes Research, Northwestern University Feinberg School of Medicine, Chicago, IL, ³Surgery, Mayo Clinic Arizona, Phoenix, AZ, ⁴Surgery, Baylor University Medical Center, Dallas, TX
*Purpose: Hispanic/Latinx patients receive disproportionately fewer living donor kidney transplants (LDKTs) than non-Hispanic Whites. [Institution name's] culturally targeted Hispanic Kidney Transplant Program (HKTP) was found…
2022 American Transplant Congress
Urinary Cell mRNA Profile Diagnosis of Borderline TCMR in Kidney Allografts
T. Salinas¹, C. Li¹, C. Snopkowski¹, K. Chen¹, S. Albakry¹, S. P. Salvatore², S. Seshan², J. R. Lee¹, M. Thangamani¹, D. Dadhania¹, M. Suthanthiran¹
¹Nephrology, Weill Cornell-NYPH, New York, NY, ²Pathology, Weill Cornell-NYPH, New York, NY
*Purpose: Borderline T cell-mediated rejection (BR) is associated with inferior outcomes. In the multicenter CTOT-04 study, we discovered and validated a urinary cell three-gene signature…