2022 American Transplant Congress
Increased Survival Benefit Amongst Highest Priority Candidates Undergoing Heart Transplant Following the New Us Heart Allocation System
*Purpose: A key policy change in the new US heart allocation system was splitting the previous highest status (1A) into statuses 1, 2, and 3…2022 American Transplant Congress
Novel Avenue of Allograft Monitoring: Direct Measurement of Donor-Derived Extracellular Vesicles in Human Plasma
Internal Medicine, Erasmus MC Transplant Institute, Rotterdam, Netherlands
*Purpose: Extracellular Vesicles (EV) - regarded as “snapshots” of their cell of origin - represent promising liquid biomarkers to monitor allograft function post transplantation. Recently,…2022 American Transplant Congress
T Cell-Specific CEACAM1 Alleviates Posttransplant Liver Injury via TIM-3 Inhibitory Regulation
UCLA Medical Center, Los Angeles, CA
*Purpose: Carcinoembryonic antigen cell adhesion molecule 1 (CEACAM1; CC1), a recently discovered ligand for T cell immunoglobulin domain and mucin domain-3 (TIM-3) on activated T…2022 American Transplant Congress
Recurrence of Membranous Nephropathy After Kidney Transplantation – TANGO Consortium
1Harvard Medical School, Boston, MA, 2Mount Sinai, New York, NY
*Purpose: Membranous nephropathy (MN) is a leading cause of nephrotic syndrome in adults. Several breakthroughs in recent decades, including the identification of anti-PLA2R Abs, aided…2022 American Transplant Congress
Derivation of a Cardiac Risk Index for Use in Liver Transplantation for Non-Alcoholic Steatohepatitis
Northwestern Memorial Hospital, Chicago, IL
*Purpose: Cardiovascular events (CVEs) are the most common cause of early mortality after liver transplant (LT), and LT candidates with non-alcoholic steatohepatitis (NASH) are at…2022 American Transplant Congress
Conversion of Tacrolimus Immediate Release to LCP Tacrolimus in Obese Kidney Transplant Recipients
*Purpose: Data describing the safety, efficacy and conversion ratio of tacrolimus immediate release (IR) to LCP-tacrolimus (LCP) in obese patients (BMI > 30) is lacking.…2022 American Transplant Congress
Predicting Urinary Tract Infections Requiring Hospitalization in Living Donor Kidney Transplant Recipients
*Purpose: Urinary tract infections (UTI) requiring hospitalization are common after kidney transplantation and are associated with increased risk of graft failure. Identifying patients at high…2022 American Transplant Congress
Enhanced Histological Yield and Actionable Findings When Biopsy is Guided by Donor-Derived Cell-Free DNA (dd-cfDNA)
*Purpose: Implementation of molecular biomarkers in kidney transplantation has expanded the amount of information available to clinicians before deciding to pursue biopsy. We evaluated how…2022 American Transplant Congress
Alloreactive Regulatory T Cells Release Distinct Subpopulations of Extracellular Vesicles Bearing Immune Regulatory Proteins and the TCR/CD3 Complex Under Antigen Specific Stimulation
Brigham and Women's Hospital, Boston, MA
*Purpose: Extracellular vesicles (EVs) are vital mediators of intercellular communication, playing an important role in the immune synapse and the T cell response. However, regulatory…2022 American Transplant Congress
Reduction in Opioid Discharge Prescribing for Kidney Transplant Recipients Through Implementation of a Standardized Opioid Prescribing Policy
*Purpose: Diversion of unused opioid medications has contributed to the opioid epidemic, and opioid use after kidney transplantation has been shown to be a risk…
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