Am J Transplant, Volume 22, Suppl 3 Archives - ATC Abstracts

2022 American Transplant Congress
HLA-II Subclasses Behave Differently Between Themselves and Between Humans: Cues to Understand Alloreactivity
S. Beland, O. Desy, M. Marcoux, M. Thivierge, J. Desgagnes, S. A. De Serres
Transplantation Unit, Renal Division, University Health Center of Quebec, Faculty of Medicine, Universite Laval, Quebec, QC, Canada
*Purpose: De novo anti-HLA-II DSAs (dnDSA) are associated with antibody-mediated rejection. However, some patients with anti-HLA-II DSAs will not develop rejection, suggesting that the development…
2022 American Transplant Congress
Pegloticase Use in Renal Transplant Recipients with Gout: Findings from an Insurance Claims Database Study
C. A. Shadur¹, B. Marder², C. Vesel², B. LaMoreaux²
¹Iowa Kidney Physicians, Des Moines, IA, ²Horizon Therapeutics plc, Deerfield, IL
*Purpose: Kidney transplant (KT) recipients have high gout incidence due to reduced eGFR and medication use associated with hyperuricemia.1 Oral urate-lowering therapies in KT patients…
2022 American Transplant Congress
Sodium-Glucose Cotransporter 2 Inhibitors to Treat Diabetes Mellitus After Kidney Transplant
H. M. Brokmeier¹, S. B. Leung¹, A. Kukla², K. C. Mara³, P. Shah⁴, Y. Kudva⁴, G. K. Mour⁵, H. M. Wadei⁶, J. M. Hill⁷, M. D. Stegall⁸, A. Lemke¹
¹Pharmacy, Mayo Clinic, Rochester, MN, ²Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN, ³Health Sciences Research, Mayo Clinic, Rochester, MN, ⁴Endocrinology, Diabetes, Metabolism, and Nutrition, Mayo Clinic, Rochester, MN, ⁵Nephrology Transplant, Mayo Clinic, Phoenix, AZ, ⁶Nephrology, Mayo Clinic, Jacksonville, FL, ⁷Transplant, Mayo Clinic, Rochester, MN, ⁸Division of Transplant Surgery, Mayo Clinic, Rochester, MN
*Purpose: This study describes experience prescribing sodium-glucose cotransport 2 inhibitors (SGLT2i) after kidney transplant to evaluate safety and effectiveness.*Methods: This is a retrospective, institutional review…
2022 American Transplant Congress
Sirolimus Regimens After Kidney Transplantation: Role of Pre-Transplant Risk Factors in Modifying the Risk of Mortality in Adult Recipients
A. Santos¹, H. Ibrahim¹, M. A. Leghrouz¹, X. Wen²
¹University of Florida, Gainesville, FL, ²University of Rhode Island, Kinston, RI
*Purpose: We aimed to investigate the role of risk factors in modifying the association of sirolimus with mortality in kidney transplant (KT) recipients (KTRs).*Methods: Using…
2022 American Transplant Congress
Coordinated, Multimodal Care After Kidney Transplantation Improves Graft Survival and Cardiovascular Risks – Results of the Kidney Transplantation 360°- Study (ktx360°)
L. Pape¹, M. DeZwaan², V. Kliem³, H. Nolting⁴, J. Wolff⁴, U. Tegtbur⁵, M. Schiffer⁶
¹Pediatrics II, University Hospital of Essen, Essen, Germany, ²Pediatrics II, Hannover Medical School, Hannover, Germany, ³Nephrologic Center Hannoversch Münden, Hannoversch Münden, Germany, ⁴IGES Insititue, Berlin, Germany, ⁵Hannover Medical School, Hannover, Germany, ⁶University Hospital of Erlangen, Erlangen, Germany
*Purpose: Cardiovascular events and reduced graft survival due to non-adherence are the most important reasons for morbidity and mortality after KTx. Outpatient care in Germany…
2022 American Transplant Congress
Bone Fractures Are Not Increased in Older Prior Living Kidney Donors
H. Amer¹, H. Maradit Kremers¹, D. Larson¹, I. Zaniletti¹, W. K. Kremers¹, A. Matas², B. Kasiske³, S. Khosla¹, R. Kumar¹
¹Mayo Clinic, Rochester, MN, ²University of Minnesota, Minneapolis, MN, ³Hennepin County Medical Center, Minneapolis, MN
*Purpose: Living kidney donors were shown to have derangements of bone biomarkers resembling those occurring in early chronic kidney disease within 36 months of donation.…
2022 American Transplant Congress
Long-Term Outcomes in Living-Donor Preemptive Kidney Transplants: Results from a Brazilian Single-Center Cohort Study
B. Beraldo, L. R. Requião-Moura, M. Gaspar, R. D. Foresto, H. Tedesco-Silva, J. Medina-Pestana
Nephrology Division - Hospital do Rim, Universidade Federal de São Paulo, São Paulo, Brazil
*Purpose: To evaluate predictors of long-term graft function and unfavorable outcomes in living-donor preemptive kidney transplant recipients.*Methods: A single-center cohort study enrolled 223 living-donor preemptive…
2022 American Transplant Congress
Treatment Modality and Outcomes of Antibody-Mediated Rejection in Pediatric Kidney Transplant Recipients: The PARAMOUr Study
R. Engen¹, A. Jain², N. Hayde³, A. Mansuri⁴, M. Kallash⁵, S. McEwen⁶, R. Garro⁷, C. Peterson⁸, R. Zahr⁹, L. Harshman¹⁰, D. Puliyanda¹¹, S. Solomon¹², K. Twombley¹³, I. Ashoor¹⁴
¹Pediatrics, University of Wisconsin Madison, Madison, WI, ²Wayne State University, Detroit, MI, ³Albert Einstein College of Medicine, New York, NY, ⁴Augusta University, Augusta, GA, ⁵The Ohio State University, Columbus, OH, ⁶University of Minnesota, Minneapolis, MN, ⁷Emory University, Atlanta, GA, ⁸University of Utah Health, Salt Lake City, UT, ⁹The University of Tennessee Health Science Center, Memphis, TN, ¹⁰University of Iowa, Iowa City, IA, ¹¹Cedars-Sinai Medical Center, Los Angeles, CA, ¹²New York Medical College, Valhalla, NY, ¹³Medical University of South Carolina, Charleston, SC, ¹⁴Louisiana State University, New Orleans, LA
*Purpose: Antibody-mediated rejection (AMR) is the leading cause of graft failure in kidney transplantation, but evidence for effective treatments is limited.*Methods: PARAMOUr is a retrospective…
2022 American Transplant Congress
Early Experience with OmniGraf® Biomarker Surveillance in Kidney Transplant Patients in the First-Year Post-Transplant and Beyond
V. Paramasivam¹, W. Ally², B. Sivakumar³, B. Greco¹, M. Germain¹
¹Baystate Medical Center, Springfield, MA, ²Eurofins Transplant Genomics, Framingham, MA, ³Dartmouth College, Hanover, NH
*Purpose: Non-invasive rejection biomarkers continue to evolve with recent data supporting the use of combined gene expression and donor derived cell-free DNA (dd-cfDNA) in kidney…
2022 American Transplant Congress
Liver Transplantation for Metabolic Liver Disease
J. Wothe, H. Bhatt, D. Vock, S. Schwarzenberg, V. Kirchner, S. Chinnakotla
University of Minnesota Medical School, Minneapolis, MN
*Purpose: Liver transplantation (LT) was initially developed as a therapy for liver diseases known to be associated with a high risk of near-term mortality. As…

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