Am J Transplant, Volume 22, Suppl 3 Archives - ATC Abstracts

2022 American Transplant Congress
Treg Crosstalk with Both Tumor and Lymphatic Cells Promotes Metastasis Through Lta1b2-ltbr Signaling
W. Piao¹, R. S. Oakes², C. M. Jewell², J. Bromberg¹
¹Surgery, University of Maryland, Baltimore, MD, ²University of Maryland, College Park, MD
*Purpose: Lymphotoxin (LT) α1β2 high expressing Tregs are essential for immune tolerance although inhibiting antitumor immunity. Lymphatic endothelial cells (LEC) express the LT beta-receptor (LTβR),…
2022 American Transplant Congress
First-in-human Study Of Lis1, A Novel Glyco-humanized Anti-lymphocyte Swine Polyclonal Antibody, In Kidney Transplantation: Safety And Efficacy
J. Slatinska¹, B. Vanhove², M. Kolarova¹, F. Shneiker², J. Rousse², C. Galli³, J. Bach⁴, E. Cozzi⁵, J. Soulillou⁶, O. Duvaux², O. Viklicky¹
¹Institute for Clinical and Experimental Medicine, Prague, Czech Republic, ²Xenothera, Nantes, France, ³Laboratorio di Tecnologie della Riproduzione, Cremone, Italy, ⁴IECM, Immunoendocrinology, USC1383, Oniris, INRAE, Nantes, France, ⁵Transplantation Immunology Unit, Padua University Hospital, Padova, Italy, ⁶Nantes Universités, Nantes, France
*Purpose: to assess safety, T cell depletion, PK/PD and determine the therapeutic dose of LIS1, a purified anti-lymphocyte glyco-humanized polyclonal swine IgG, derived by immunizing…
2022 American Transplant Congress
Clazakizumab® (anti-il-6) Desensitization in Highly-HLA Sensitized Patients Awaiting Kidney Transplant (nct03380962): Long-Term Follow Up
A. Vo¹, J. Tang¹, N. Ammerman¹, E. Huang¹, X. Zhang², M. Haas³, A. Peng¹, R. Najjar¹, S. Williamson¹, C. Meyers¹, S. Sethi¹, K. Lim¹, M. Gillespie¹, N. Badash¹, S. Jordan¹
¹Comprehensive Transplant Center, Cedars Sinai Medical Ctr, Los Angeles, CA, ²HLA Laboratory, Cedars Sinai Medical Ctr, Los Angeles, CA, ³Pathology, Cedars Sinai Medical Ctr, Los Angeles, CA
*Purpose: IL-6 is a cytokine critical for B-cell activation and IgG production. Clazakizumab (CSL Behring LLC) is a humanized monoclonal aimed at the cytokine IL-6.…
2022 American Transplant Congress
Intraoperative Kinetics of Pro-Inflammatory Markers and Delayed-Graft Function During Kidney Transplantation
P. A. Wadsworth, H. L. Stevenson, M. L. Kueht
University of Texas Medical Branch, Galveston, TX
*Purpose: Detailed molecular changes associated with allograft reperfusion have been poorly defined and current methods of predicting delayed graft function (DGF) after kidney transplantation are…
2022 American Transplant Congress
Survival Benefit of Preemptive Simultaneous Pancreas Kidney Transplantation
E. Montagud-Marrahi¹, E. Cuadrado-Payán¹, E. Hermida¹, D. Cucchiari¹, I. Revuelta¹, J. Del Risco-Zevallos¹, J. Casals¹, N. Esforzado¹, F. Cofan¹, F. Oppenheimer¹, V. Torregrosa¹, J. Ferrer², A. J. Amor³, E. Esmatjes¹, M. Ramirez-Bajo⁴, M. Musquera⁵, B. Bayés¹, J. Campistol¹, F. Diekmann¹, P. Ventura-Aguiar¹
¹Nephrology and Kidney Transplantation Department, Hospital Clínic of Barcelona, Barcelona, Spain, ²Hepatobiliopancreatic and Liver Transplant Department, Hospital Clínic of Barcelona, Barcelona, Spain, ³Diabetes Unit. Endocrinology and Nutrition Department, Hospital Clínic of Barcelona, Barcelona, Spain, ⁴Laboratori Experimental de Nefrologia I Trasplantament (LENIT), Fundació Clínic per a la Recerca, Hospital Clínic of Barcelona, Barcelona, Spain, ⁵Urology Department, Hospital Clínic of Barcelona, Barcelona, Spain
*Purpose: Diabetes mellitus is a well-established risk factor for morbidity and mortality among patients on dialysis, but the evidence regarding the benefits of performing preemptive…
2022 American Transplant Congress
Financial Impact of a Culturally Sensitive Hispanic Kidney Transplant Program
J. Caicedo¹, A. Wang², A. Mathur³, R. Ruiz⁴, E. J. Gordon¹
¹Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL, ²Center for Health Services and Outcomes Research, Northwestern University Feinberg School of Medicine, Chicago, IL, ³Surgery, Mayo Clinic Arizona, Phoenix, AZ, ⁴Surgery, Baylor University Medical Center, Dallas, TX
*Purpose: Hispanic/Latinx patients receive disproportionately fewer living donor kidney transplants (LDKTs) than non-Hispanic Whites. [Institution name's] culturally targeted Hispanic Kidney Transplant Program (HKTP) was found…
2022 American Transplant Congress
Urinary Cell mRNA Profile Diagnosis of Borderline TCMR in Kidney Allografts
T. Salinas¹, C. Li¹, C. Snopkowski¹, K. Chen¹, S. Albakry¹, S. P. Salvatore², S. Seshan², J. R. Lee¹, M. Thangamani¹, D. Dadhania¹, M. Suthanthiran¹
¹Nephrology, Weill Cornell-NYPH, New York, NY, ²Pathology, Weill Cornell-NYPH, New York, NY
*Purpose: Borderline T cell-mediated rejection (BR) is associated with inferior outcomes. In the multicenter CTOT-04 study, we discovered and validated a urinary cell three-gene signature…
2022 American Transplant Congress
Local Cognate Antigen in Kidney Allografts Promotes Tissue Resident Memory T Cell Maintenance
R. Tieu¹, Q. Zeng¹, D. Zhao¹, P. Manandhar², A. Williams¹, K. Abou-Daya¹, L. Kane², W. Shlomchik¹, M. Oberbarnscheidt¹, F. Lakkis¹
¹Starzl Transplantation Institute, Pittsburgh, PA, ²Department of Immunology, University of Pittsburgh, Pittsburgh, PA
*Purpose: Our lab has demonstrated that tissue resident memory T cells (TRM cells) sustain chronic kidney allograft rejection in mice. It remains unknown how TRM…
2022 American Transplant Congress
Clear Gender Disparity in Living Donor Kidney Transplants
A. C. Gruessner¹, R. Gruessner²
¹Medicine, SUNY Downstate Medical Center, Brooklyn, NY, ²SUNY Downstate Medical University, Brooklyn, NY
*Purpose: Over the last years, the number of kidney transplants from living donors (LD) increased. However, more male than female patients received a LD transplant…
2022 American Transplant Congress
Racial Barriers to Kidney Transplant After Listing, 2015 – 2020
W. T. McKinney¹, D. Schladt², J. Miller², T. Weaver², J. Pyke², T. Madhusoodanan³, A. K. Israni¹
¹Nephrology, Hennepin Healthcare Research Institute, Minneapolis, MN, ²Scientific Registry of Transplant Recipients, Minneapolis, MN, ³Nephrology, Hennepin Healthcare, Minneapolis, MN
*Purpose: We sought to evaluate racial disparities in access to deceased donor kidney transplant (DDKT) following changes to kidney allocation system (KAS) implemented in 2014.…

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