Am J Transplant, Volume 21, Suppl 3 Archives - Page 90 of 139 - ATC Abstracts

2021 American Transplant Congress
CD40 Blockade by the Fc-Silent Immunosuppressive Antibody Iscalimab Results in Diminished B Cell Activation and Differentiation and is Paralleled by Whole Blood Gene Expression Data
R. Kraaijeveld¹, M. W. van den Hoogen¹, A. E. de Weerd¹, E. Ferroro², G. Robert², U. Laessing², B. Haraldsson², J. S. Rush², C. C. Baan¹
¹Erasmus MC, Rotterdam, Netherlands, ²Novartis Pharmaceuticals AG, Basel, Switzerland
*Purpose: Blockade of costimulatory molecule CD40 by the Fc-silent immunosuppressive drug Iscalimab has shown to inhibit acute alloreactivity in non-human primates and is currently being…
2021 American Transplant Congress
Clinical Value of Surveillance Biopsies in Pediatric Liver Transplantation: A Single Center Experience with >800 Biopsies
B. Rocque¹, A. Zaldana¹, C. Weaver², J. Huang¹, A. Barbetta¹, V. Shakhin², C. Goldbeck¹, G. Yanni², R. Kohli², Y. Genyk¹, J. Emamaullee¹
¹Surgery, University of Southern California Keck School of Medicine, Los Angeles, CA, ²Pediatrics, Children’s Hospital-Los Angeles, Los Angeles, CA
*Purpose: While pediatric liver transplantation (LT) results in excellent long-term outcomes, a high incidence of early acute cellular rejection (ACR) and late graft fibrosis persists.…
2021 American Transplant Congress
Results of the Transplant Advance Practice Provider Survey: Opportunities for APPs to Contribute to Academic Pursuits
B. Muth¹, D. Krieger², N. McCormick³, M. Siegfired⁴, H. Domingo⁵, J. Yoo⁶, A. Frank⁷, K. Paolini⁸, A. Mayfield⁹, H. McDade⁹, A. Borth⁹, H. Hoy¹⁰
¹University of Wisconsin, Madison, WI, ²UCSF, San Francisco, CA, ³University of Colorado, Denver, CO, ⁴Swedish Organ Transplant, Seattle, WA, ⁵Northwestern, Chicago, IL, ⁶Rush, Chicago, IL, ⁷Medstar Georgetown University, Annandale, VA, ⁸Erie County Medical Center, Grand Island, NY, ⁹University of Maryland, Baltimore, MD, ¹⁰University of Alabama - Huntsville, Huntsville, AL
*Purpose: The pillars of academic medicine are research, education and patient care. While transplant Advance Practice Providers (APPs) are primarily recruited for clinical roles, many…
2021 American Transplant Congress
Change in Deceased Donor Demographics with Drug Intoxication Deaths: 2010 – 2019
D. Musgrove, D. Zaun, A. Israni, J. Snyder
SRTR, Minneapolis, MN
*Purpose: To understand the demographic change in deceased donor causes of death associated with drug intoxication, we explored trends over the 10-year period ending in…
2021 American Transplant Congress
A Fresh Look at Urbanicity and Its Impact on Additions to the Kidney and Liver Transplant Wait Lists
W. R. Johnson, S. A. Rega, I. D. Feurer, S. J. Karp
General Surgery, Vanderbilt University Medical Center, Nashville, TN
*Purpose: Our aim is to examine the collective effects of social determinants of health (SDH) on kidney and liver wait list additions in the United…
2021 American Transplant Congress
The Relationship Between Health Literacy and Adverse Outcomes After Kidney Transplantation
E. Lorenz, T. Petterson, C. Schinstock, W. Sanchez, K. Yost
Mayo Clinic, Rochester, MN
*Purpose: Limited health literacy has been associated with a decreased likelihood of listing for transplant and an increased risk of waitlist mortality among kidney transplant…
2021 American Transplant Congress
Natural Sensitization by Pregnancy, Testing Desensitization Strategies in Female NHPs Across Repeat Mismatches
M. Manook, J. Yoon, Z. Fitch, R. Schmitz, A. M. Jackson, J. Kwun, S. Knechtle
Duke Transplant Center, Duke University Medical Center, Durham, NC
*Purpose: Women are disproportionately represented in the highly sensitized patient cohort, and HLA-incompatible transplantation is undertaken predominantly in females. However, nonhuman primate (NHP) models to…
2021 American Transplant Congress
Association of Donor Hepatitis C Virus Infection Status and Risk of Bk Polyomavirus Viremia After Kidney Transplantation
V. S. Potluri¹, D. E. Schaubel¹, M. E. Sise², B. P. Concepcion³, R. C. Forbes¹, E. A. Blumberg¹, D. Goldberg⁴, P. P. Reese¹, R. Bloom¹, D. Shaffer³, R. Chung², D. Sawinski¹, I. Strohben², N. Elias², A. Azhar⁵, M. Shah¹, J. Eason⁵, L. A. Binari³, M. Talwar⁵, V. Balaraman⁵, A. Bhalla⁵, B. Besharatian¹, M. Z. Molnar⁵
¹University of Pennsylvania, Philadelphia, PA, ²Massachusetts General Hospital, Boston, MA, ³Vanderbilt University Medical Center, Nashville, TN, ⁴University of Miami Miller School of Medicine, Miami, FL, ⁵Methodist University Hospital, Memphis, TN
*Purpose: Transplantation of kidneys from deceased donors with hepatitis C virus (HCV) infection into HCV-negative recipients has become more common, but some studies have suggested…
2021 American Transplant Congress
Cleveland Clinic Experience with Cadaveric Uterus Transplant
L. Del Prete¹, C. Quintini¹, K. Hashimoto¹, B. Eghtesad¹, G. D'Amico¹, C. Kwon¹, D. Priebe¹, E. Richards¹, S. Ricci¹, U. Perni¹, C. Ferrando¹, A. Chiesa-Vottero¹, S. Mawhorter¹, N. Yeaney¹, R. Farrell¹, R. Flyckt², C. Miller¹, T. Falcone¹, A. Tzakis¹
¹Cleveland Clinic, Cleveland, OH, ²University Hospital, Cleveland, OH
*Purpose: Uterus transplantation (UTx) is the only treatment for women with uterine factor infertility (UFI). The majority of overall experience is from living donation. Little…
2021 American Transplant Congress
Primary Outcome of OPTIMAL: A Prospective Multicenter Trial of Immunosuppression Withdrawal (ISW) in Stable Adult Liver Transplant (LT) Recipients
S. Chandran¹, K. Mason², L. F. Sun¹, N. Tanimine³, M. DesMarais¹, B. Burrell¹, J. F. Markmann³
¹ITN, San Francisco, CA, ²Rho, Inc., Durham, NC, ³MGH, Boston, MA
*Purpose: To identify clinical & mechanistic correlates of successful ISW and operational tolerance (OT) in a selected cohort of adult LT recipients.*Methods: The Immune Tolerance…