2021 American Transplant Congress
Elexacaftor/ivacaftor/tezacaftor in Lung Transplant Recipients: A Case Series
1University of Chicago Medicine, Chicago, IL, 2Roosevelt University, Chicago, IL
*Purpose: Little data is published describing the safety or efficacy of elexacaftor/ivacaftor/tezacaftor in lung transplant recipients. Even though it is not expected to offer pulmonary…2021 American Transplant Congress
Towards National Organ Sharing: Fair Distribution of Eplets in Canada
McGill University, Montreal, QC, Canada
*Purpose: Eplet matching is being promoted as a rational approach to prevent immune-mediated injuries in transplantation. We studied the frequencies of eplets in a Canadian…2021 American Transplant Congress
Measuring the Impact of Targeting FcRn-Mediated IgG Recycling on Donor-Specific Alloantibodies in a Sensitized NHP Model
*Purpose: In transplantation, plasmapheresis and IVIg provide the mainstay of treatment directed at reducing or removing circulating donor specific antibody (DSA), yet both have limitations.…2021 American Transplant Congress
Risk Stratification of Kidney Transplant Patients According to the Different Level of HLA-DQ Disparities
*Purpose: It is becoming clear that de novo donor-specific antibodies (dnDSA) against HLA-DQ are the most prevalent and the leading cause of chronic antibody-mediated rejection…2021 American Transplant Congress
Impact of a Pharmacist-driven Immunization Clinic on Vaccination Rates in Pre-liver Transplant Patients
*Purpose: Infectious diseases are a leading cause of morbidity and mortality among patients with end-stage liver disease (ESLD). Vaccination data of ESLD patients pre- and…2021 American Transplant Congress
The Utility of PET/ CT Testing in Cardiac Risk Stratification of Adult Liver Transplant Candidates
*Purpose: Optimal cardiovascular (CV) risk stratification in liver transplant (LT) candidates remains unclear. The aim of this study was to assess concordance and utility of…2021 American Transplant Congress
Ikaros-SIRT1 Signaling Axis Regulates Macrophage Polarization and Ischemia Reperfusion Injury in Mouse and Human Liver Transplantation
1The Dumont-UCLA Transplant Center, Los Angeles, CA, 2NIEHS, Durham, NC
*Purpose: Although Ikaros is a well-established transcriptional regulator of lymphopoiesis and differentiation of leukocyte lineage, its role in myeloid cells and ischemia reperfusion injury remain…2021 American Transplant Congress
Immunosuppression Reduction Strategies for Polyoma BK Viremia in Kidney Transplant Patients on Belatacept-Based Immunosuppression
*Purpose: The mainstay of treatment for BK infection is immunosuppression (IS) reduction, however limited literature provides guidance for treatment of patients with a belatacept-based IS…2021 American Transplant Congress
Rural Dialysis Facilities are Associated with Better Dialysis Quality but Less Home Dialysis Use
1Surgery, Brigham and Women's Hospital, Boston, MA, 2Medicine, Boston Medical Center, Boston, MA
*Purpose: Dialysis facility quality is associated with patient outcomes. The 60 million rural dwellers across the United States are older, more likely to live in…2021 American Transplant Congress
Precision Medicine in Renal Transplantation: Structural Biology of HLA Defines Allelic Binding of Cardinal Pathogenic Viruses in Transplantation
*Purpose: The incidence, clearance and clinical expression of viremia post-Tx are heterogeneous, complicating prediction, prognosis and therapy. We postulated that variation viral presentation related to…
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