Am J Transplant, Volume 21, Suppl 3 Archives - Page 80 of 139 - ATC Abstracts

2021 American Transplant Congress
DSA is Associated with Molecular Changes in Many Hearts with Minor Abnormalities but Not Diagnosed as Antibody-Mediated Rejection
P. Halloran¹, K. S. Madill-Thomsen¹, &. the INTERHEART Study Group²
¹Alberta Transplant Applied Genomics Centre, Edmonton, AB, Canada, ²., ., AB, Canada
*Purpose: We previously developed a microarray-based diagnostic system (MMDx) for heart transplant endomyocardial biopsies, measuring gene expression and interpreting antibody-mediated and T cell-mediated rejection (ABMR,…
2021 American Transplant Congress
Influence of Induction Therapy and Antiretroviral Regimen on Outcomes in HIV Positive Renal Transplant Recipients
C. Rogers Marks¹, C. Durand², J. Hand³, M. Abidi⁴, M. Malinis⁵, B. Barnaba², H. Patel⁶, C. D. Alonso⁶
¹Massachussetts General Hospital, Boston, MA, ²Johns Hopkins Medical Center, Baltimore, MD, ³Ochsner Medical Center, New Orleans, LA, ⁴Univ. of Colorado, Aurora, CO, ⁵Yale, New Haven, CT, ⁶Beth Israel Deaconess Medical Center, Boston, MA
*Purpose: Transplantation of HIV+ individuals has become more common over the past decade with increasing data supporting good outcomes. Questions remain regarding the impact of…
2021 American Transplant Congress
Kidney Donor Risk Index: Significance as a Predictor of Kidney Transplant Outcomes Beyond Allograft Survival, Analysis of 18 Adjusted Regression Models Involving Adult Deceased Donor Kidney Recipients
A. Santos, E. Bueno, M. A. Leghrouz
University of Florida, Gainesville, FL
*Purpose: We aimed to study the role of kidney donor recipient index (KDRI) as a predictor for multiple transplant-related outcomes in adult deceased-donor (DD) kidney…
2021 American Transplant Congress
Renal Preservation with Belatacept-Based versus Everolimus-Based Immunosuppression in Lung Transplant Recipients
E. Sartain¹, K. Schoeppler¹, B. Crowther¹, J. Smith², A. Gray²
¹University of Colorado Skaggs School of Pharmacy and Pharmaceutical Sciences, Aurora, CO, ²Department of Medicine, Division of Pulmonary Sciences and Critical Care, University of Colorado, Denver, CO
*Purpose: Renal dysfunction is one of the most common long-term complications among lung transplant recipients (LTRs). Calcineurin-inhibitor (CNI) nephrotoxicity is a recognized contributor to renal…
2021 American Transplant Congress
Non-Invasive Measurement of Transplant Kidney Fibrosis Using Photoacoustic Imaging
E. Hysi¹, X. He¹, A. Krizova¹, M. Ordon¹, K. T. Pace¹, M. Farcas¹, M. C. Kolios², D. A. Yuen¹
¹St. Michael's Hospital, Toronto, ON, Canada, ²Ryerson University, Toronto, ON, Canada
*Purpose: The presence of donor kidney fibrosis adversely impacts transplant outcome. Biopsy remains the only method that can assess fibrosis, despite being subjected to sampling…
2021 American Transplant Congress
Donor-derived Cell-free DNA Distinguishes Acute Rejection from Other Causes of Graft Injury in Liver Transplant Recipients
J. Levitsky¹, M. Miller², R. Sinha², E. Bixler², A. Al-Turck², J. Weems², M. Altrich², S. Kleiboeker², M. Abecassis³
¹Gastroenterology & Hepatology; Comprehensive Transplant Center, Northwestern University, Chicago, IL, ²Viracor Eurofins, Lees Summit, MO, ³University of Arizona College of Medicine Tucson, Tucson, AZ
*Purpose: The donor derived cell-free DNA (ddcfDNA) has emerged as strong biomarker for allograft injury, where the fraction of ddcfDNA is reported to increase in…
2021 American Transplant Congress
Association Between HLA Class II and TLR4 Regulates HLA-II Stimulated P-selectin Expression and Monocyte Capture to Endothelial Cells
Y. Jin, J. Nevarez-Mejia, E. F. Reed
Pathology and Laboratory Medicine, University of California Los Angeles, Los Angeles, CA
*Purpose: Antibody-mediated rejection (AMR) is a major obstacle for long-term allograft survival. Donor specific HLA antibodies (DSA) contribute to the process of AMR by binding…
2021 American Transplant Congress
Epidemiology and Risk Factors for Invasive Fungal Infection in Pancreas Transplant in the Absence of Fungal Prophylaxis
J. Burkey¹, J. M. Chen², A. A. Sharfuddin², M. S. Yaqub², A. J. Lutz², J. A. Powelson², J. A. Fridell², N. Barros²
¹Butler University College of Pharmacy and Health Sciences, Indianapolis, IN, ²Indiana University Health, Indianapolis, IN
*Purpose: Invasive fungal infections (IFI) remain a rare yet dreaded complication following pancreas transplantation. Current guidelines recommend antifungal prophylaxis in patients with 1 or more…
2021 American Transplant Congress
Outcomes After Liver Transplantation With Steatotic Grafts: Redefining Acceptable Cutoffs for Moderately Steatotic Grafts
B. L. Da¹, J. Satiya², R. P. Heda³, Y. Jiang⁴, L. Lau⁵, A. Fahmy¹, A. Winnick¹, N. Roth¹, E. Grodstein¹, P. J. Thuluvath⁶, A. K. Singal⁷, T. D. Schiano⁸, L. W. Teperman¹, S. K. Satapathy¹
¹Liver Disease, Northwell Health, Manhasset, NY, ²Beth Israel Deaconess Medical Center, Boston, MA, ³Tulane Medical Center, Memphis, TN, ⁴The University of Memphis, Memphis, TN, ⁵Northwell Health, Manhasset, NY, ⁶University of Maryland School of Medicine, Baltimore, MD, ⁷Liver Disease, Avera McKenna University Health Center and Transplant Institute, Manhasset, NY, ⁸Icahn School of Medicine at Mount Sinai, New York City, NY
*Purpose: Graft macro-steatosis can predispose to worse graft survival. Our objective was to redefine acceptable cutoffs for graft steatosis using the national database.*Methods: Data of…
2021 American Transplant Congress
PD-1/PD-L1 Selectively Regulates Treg Lymphatic Migration
W. Piao¹, L. Li¹, C. Paluskievicz¹, Y. Zhang², V. Saxena³, K. Hippen², B. Blazar², L. Riella⁴, J. Bromberg¹
¹Surgery, U Maryland, Baltimore, MD, ²U Minnesota, Minneapolis, MN, ³U Maryland, Baltimore, MD, ⁴Harvard U, Boston, MA
*Purpose: The molecules that regulate Treg migration are incompletely identified. Programmed death-1 (PD-1) and its ligand PD-L1 are immune checkpoint proteins which regulate immune cell…