Session Name: Pancreas and Islet: All Topics
Session Date & Time: None. Available on demand.
*Purpose: UNOS approved simultaneous kidney-pancreas transplantation (SKPT) for type-II diabetes mellitus (DM) in Oct 2014. There is limited data comparing outcomes of SKPT in type-I versus type-II DM. The aim of this study was to measure the change in volume of SKPT since UNOS approved it for type-II DM patients and compare death-censored 5-year kidney and pancreas graft and patient survival between type-I and type-II DM patients undergoing SKPT.
*Methods: We conducted a single-center retrospective chart-review study on SKPT patients from Jan 2010 to Nov 2020 and collected data on patient demographics, BMI, c-peptide, HbA1c, and eGFR. Student’s t-test for continuous variables, Chi-square test for categorical variables, and Log rank test for survival analysis were done using SPSS.
*Results: Among 89 SKPT, 18 (all type-I DM) and 71 (41 type-I and 30 type-II DM) were done pre- and post-approval of SPKT for type-II DM respectively. This translated to an increase in SKPT from 3.6/year to 11.8/year (228% increase). There were no statistically significant differences in c-peptide and HbA1c levels pre- and 1-year post-SKPT. Patients with type-II DM were of older age and had higher BMI and eGFR 1-year post-SKPT. There were no statistically significant differences in death-censored kidney and pancreas graft and patient survival at 5-year post-SKPT.
|DM type-I (n=59)||DM type-II (n=30)||P-Value|
|Age (Y), mean ± SD||40.2 ± 9.5||47.4 ± 8.8||<0.01|
|Male, % (n)||62.1 (36)||61.3 (19)||0.94|
|BMI (kg/m2) Pre-SKPT, mean ± SD||25.9 ± 4.2||27.0 ± 2.8||0.15|
|BMI (kg/m2) 1-Year Post-SKPT, mean ± SD||26.7 ± 4.6||32.0 ± 3.7||<0.01|
|eGFR (ml/min/1.73m2) Pre-SKPT, mean ± SD||13.0 ± 8.0||13.6 ± 9.3||0.83|
|eGFR (ml/min/1.73m2) 1-Year Post-SKPT, mean ± SD||62.0 ± 18.6||76.7 ± 22.6||0.04|
|Death-Censored 5-Year Kidney Graft/Pancreas Graft/Patient Survival, %||84.7/88.1/94.9||93.3/93.3/90.0||0.63/0.65/0.27|
*Conclusions: Approval of SKPT for type-II DM by UNOS led to an increase in SKPT with no differences in graft or patient survival between patients with type-I and type-II DM.
To cite this abstract in AMA style:Shokouh-Amiri H, Naseer MS, Palermini A, Aultman D, McMillan R, Tandukar S, Singh N, Zibari G. Outcomes of Simultaneous Kidney-Pancreas Transplantation in Patients with Type-I and Type-II Diabetes Mellitus [abstract]. Am J Transplant. 2021; 21 (suppl 3). https://atcmeetingabstracts.com/abstract/outcomes-of-simultaneous-kidney-pancreas-transplantation-in-patients-with-type-i-and-type-ii-diabetes-mellitus/. Accessed September 22, 2021.
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