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American Transplant Congress abstracts

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  • 2021 American Transplant Congress

    Growing LDLT Volumes at a US Center- What Does It Take to Do Over 100 LDLTs Per Year

    A. Humar, C. Hughes, G. Mazariegos, K. Soltys, A. Gallatin, K. Emmett, A. Tevar, M. Molinari, A. Ganoza, V. Gunabushanam, S. Ganesh

    University of Pittsburgh, Pittsburgh, PA

    *Purpose: LDLT remains underutilized in the US, accounting for
  • 2021 American Transplant Congress

    Effective Patient Throughput on the Transplant Surgery Service

    E. M. Thomas1, P. K. Shah1, S. Beasley2, A. Saad1, M. Rani1, F. Cigarroa1

    1UT Health San Antonio, San Antonio, TX, 2University Health, San Antonio, TX

    *Purpose: Hospital bed capacity and patient throughput are persistent challenges for medical centers. One established strategy for increasing patient throughput and decompressing Emergency Departments is…
  • 2021 American Transplant Congress

    The Role of Donor-derived Cell-free DNA to Detect Subclinical Acute Rejection in Kidney Allograft

    S. Park1, K. Guo2, R. Heilman3, E. Poggio4, D. Taber5, C. Marsh6, S. Kurian7, S. Kleiboeker8, J. Weems9, J. Holman10, L. Zhao2, R. Sinha8, S. Brietigam2, C. Rebello2, M. Abecassis11, J. Friedewald1

    1Transplant nephrology, Northwestern University, Chicago, IL, 2Feinberg School of Medicine, Northwestern University, Chicago, IL, 3Transplant nephrology, Mayo Clinic College of Medicine and Science, Phoenix, AZ, 4Department of Nephrology and Hypertension, Cleveland Clinic, Cleveland, OH, 5Division of Transplant Surgery, Medical University of South Carolina, Charleston, SC, 6Department of Medicine and Surgery, Scripps Clinic and Green Hospital, La Jolla, CA, 7Scripps Health, La Jolla, CA, 8Eurofins US Clinical Diagnostics, Lee's Summit, MO, 9Eurofins US Clinical Diagnostics, Lee’s Summit, MO, 10Transplant Genomics, Inc, Mansfield, MA, 11University of Arizona College of Medicine, Northwestern University, Tucson, AZ

    *Purpose: We hypothesized that donor-derived cell-free DNA (dd-cfDNA) could detect subclinical acute rejection (subAR).*Methods: 429 blood samples paired with surveillance kidney biopsies from 208 patients…
  • 2021 American Transplant Congress

    Inflammation in Scarred Cortex (i-IFTA) is Significantly Associated with T Cell-mediated Rejection (TCMR), but Not Antibody-mediated Rejection (ABMR), in Renal Allograft Biopsies (Bx)

    H. Zhang

    Transplant Immunology Laboratory, Cedars-Sinai Medical Center, Los Angeles, CA

    *Purpose: I-IFTA in renal allograft Bx has been found to be associated with decreased death-censored graft survival. Moderate to severe i-IFTA (2 or 3) is…
  • 2021 American Transplant Congress

    Effect of HLA Class II Polymorphism on Predicted Cellular Immunity Against SARS-CoV-2 at the Individual Level and Within Twenty Five Race/ethnic Groups

    H. C. Copley1, L. Gragert2, A. R. Leach3, V. Kosmoliaptsis1

    1Department of Surgery, University of Cambridge, Cambridge, United Kingdom, 2Department of Pathology, Tulane University School of Medicine, New Orleans, LA, 3European Bioinformatics Institute (EMBL-EBI), Hinxton, United Kingdom

    *Purpose: Development of adaptive immunity after COVID-19 and after vaccination against SARS-CoV-2 is predicated on recognition of viral peptides, presented on HLA class II molecules,…
  • 2021 American Transplant Congress

    TOLS are Novel Regulatory TLOs with A B Cell Signature

    I. Rosales1, Q. Yuan1, C. Yang1, P. Russell1, J. Madsen1, A. Alessandrini1, R. Colvin1, -. AA and RC2

    1Massachusetts General Hospital, Boston, MA, 2Co-Senior Authors, Boston, MA

    *Purpose: Our previous studies suggest that a DBA/2 kidney graft is accepted by a MHC-fully mis-matched C57/BL6 recipient. Accepted renal allografts exhibited lymphoid like structures…
  • 2021 American Transplant Congress

    Immunosuppression and Cancer Risk in Kidney Transplant Recipients: A Retrospective Cohort Study

    R. Sapir-Pichhadze1, C. Laprise1, X. Zhang1, M. Abrahamowicz1, M. Beauchamp2, A. Della Vecchia1, L. Azoulay1, E. Franco1, B. Nicolau1

    1McGill University, Montreal, QC, Canada, 2McGill University Health Centre, Montreal, QC, Canada

    *Purpose: Kidney transplant recipients (KTR) have an elevated risk of cancer. We sought to estimate to what extent does the immunosuppression regimen increase KTRs’ susceptibility…
  • 2021 American Transplant Congress

    Are All DSA’s the Same? Are We Ready for Precision Medicine in Pediatric LT?

    S. E. Shin1, M. Lee1, N. Yazigi2, K. Khan2, S. Kaufman2, J. Ahn3, O. Timofeeva4, U. Ekong2

    1Georgetown University School of Medicine, Washington, DC, 2Medstar Georgetown Transplant Institute, Medstar Georgetown University Hospital, Washington, DC, 3Biostatistics, Bioinformatics, & Biomathematics, Georgetown University, Washington, DC, 4Histocompatibility Laboratory, Dept. of Pathology & Laboratory Medicine, Georgetown University, Washington, DC

    *Purpose: Donor-specific antibodies (DSA) play an uncertain role in rejection after liver transplantation (LT). We hypothesized that evaluation of epitope differences in HLA-DR/DQ mismatching can…
  • 2021 American Transplant Congress

    Atg16l-Dependent Autophagy Attenuates Procession of Renal Interstitial Fibrosis in Chronic Renal Graft Dysfunction via Regulating Tumor Necrosis Factor Alpha (tnf-α) Induced Endmt

    Z. Gui, Z. Wang, Z. Han, J. Tao, X. Ju, R. Tan, M. Gu

    The First Affiliated Hospital of Nanjing Medical University, Nanjing, China

    *Purpose: Chronic renal graft dysfunction is characterized by inflammation, tubular injury, and interstitial fibrosis. We have confirmed that endothelial-mesenchymal transition (EndMT) was one of important…
  • 2021 American Transplant Congress

    Development of De Novo Antibody in Renal Transplant Recipients with BK Viremia Managed with Immunosuppression Reduction

    R. Hod Dvorai1, R. Lee2, P. Muluhngwi2, M. Raijmakers3, A. Shetty2, A. Tambur2, M. Ison2

    1SUNY Upstate Medical University, Syracuse, NY, 2Northwestern University, Chicago, IL, 3University of Santiago, Santiago, Chile

    *Purpose: To evaluate development of de novo donor specific antibodies (dnDSA) in Renal Transplant Recipients (RTR) with immunosuppression (IS) modulation due to BK viremia (BKV)…
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