2021 American Transplant Congress
CD47-Mediated Gli1/Notch1 Signaling is a Key Regulator of Mesenchymal Stem Cell Immunomodulation in Liver Inflammatory Injury
Surgery, Dumont - UCLA Transplant Center, Los Angeles, CA
*Purpose: The CD47-signal regulatory protein alpha (SIRPα) signaling pathway plays important roles in immune homeostasis and tissue inflammatory response. Gli1, the downstream effector of the…2021 American Transplant Congress
Beyond Microarrays: Insights from Ncounter Transcript Analysis of Routine Archival Kidney Allograft Biopsies
Massachusetts General Hospital, Boston, MA
*Purpose: Microarray mRNA analysis of renal allograft biopsies has discovered important insights, but has limitations as a practical clinical test. Here we evaluate a new…2021 American Transplant Congress
Effect of Early Biopsy-Proven Rejection on Liver Transplant Outcomes
Surgery, University of Wisconsin, Madison, WI
*Purpose: Existing literature offers conflicting conclusions about whether early acute cellular rejection influences long-term outcomes in liver transplantation.*Methods: We retrospectively collected donor and recipient data…2021 American Transplant Congress
Eosinophils Attenuate Hepatic Ischemia Reperfusion Injury in Mice Through St2-Dependent Il-13 Production
*Purpose: The purpose is to investigate the functional role of eosinophils during hepatic ischemia and reperfusion injury (IRI).*Methods: Mice with antibody-induced eosinophil depletion and two…2021 American Transplant Congress
Pre- Kidney Donation Pregnancy Complications and Long-Term Outcomes
*Purpose: In general, hypertension (HTN), proteinuria, or diabetes (DM) are exclusion criteria for living kidney donation in young candidates. Exceptions are made for conditions only…2021 American Transplant Congress
A Cost Benefit Analysis of Different Minimal Access Donor Nephrectomy Techniques Performed at a Busy Transplant Centre
*Purpose: We performed the cost-benefit analyses comparing Total Laparoscopic Retroperitoneoscopic donor nephrectomy (TLTLRPDN) versus Hand-assisted laparoscopic donor nephrectomy (HALDN) operations performed at our centre since…2021 American Transplant Congress
Exosomal DAMP Proteins Released During Islet Isolation Affects TPIAT Outcomes
Hume Lee Islet Cell Transplantation Lab, Department of Surgery, VCU Health, Richmond, VA
*Purpose: Isolation of islets cause significant stress that results in the release of immunogenic factors called damage-associated molecular patterns (DAMPs) which can induce inflammatory signaling…2021 American Transplant Congress
Pre-transplant Lower Urinary Tract Dysfunction in Men is a Risk Factor for Adverse Outcomes Following Renal Transplantation
*Purpose: The expanding age criteria for candidacy for renal transplantation, in conjunction with prolonged waiting time for deceased donor kidneys has created new challenges for…2021 American Transplant Congress
Single Day Centralized Approach in Kidney Transplant Workup – Lessons Learned from 2 Centers
Tulane Abdominal Transplant Institute, New Orleans, LA
*Purpose: Time from transplant evaluation to UNOS listing is unaccounted towards wait-list time in pre-dialysis patients and hence longer evaluation to listing times can prolong…2021 American Transplant Congress
Belatacept and Rapamycin Maintenance Immunosuppression in a Sensitized Nonhuman Primate Kidney Allotransplantation Model
*Purpose: Desensitization with costimulation blockade and proteasome inhibition prior to kidney transplantation prevents early antibody-mediated rejection (AMR) and prolongs graft survival in highly sensitized nonhuman…
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