2021 American Transplant Congress
Pre-transplant Lower Urinary Tract Dysfunction in Men is a Risk Factor for Adverse Outcomes Following Renal Transplantation
*Purpose: The expanding age criteria for candidacy for renal transplantation, in conjunction with prolonged waiting time for deceased donor kidneys has created new challenges for…2021 American Transplant Congress
Single Day Centralized Approach in Kidney Transplant Workup – Lessons Learned from 2 Centers
Tulane Abdominal Transplant Institute, New Orleans, LA
*Purpose: Time from transplant evaluation to UNOS listing is unaccounted towards wait-list time in pre-dialysis patients and hence longer evaluation to listing times can prolong…2021 American Transplant Congress
Belatacept and Rapamycin Maintenance Immunosuppression in a Sensitized Nonhuman Primate Kidney Allotransplantation Model
*Purpose: Desensitization with costimulation blockade and proteasome inhibition prior to kidney transplantation prevents early antibody-mediated rejection (AMR) and prolongs graft survival in highly sensitized nonhuman…2021 American Transplant Congress
Antibodies to Hla Molecules Lead to Induction and Release of Circulating Exosomes with Lung Self-Antigens
St. Joseph’s Hospital and Medical Center, Phoenix, AZ
*Purpose: Antibodies (Abs) to human leukocyte antigen (HLA) (anti-HLA) can injure allograft by complement-dependent/independent mechanisms. Crosslinking of HLA-class I with Abs associate with integrin β4…2021 American Transplant Congress
First Full Reversal of Diabetes in Non-human Primates (nhp) with Stem Cell Derived Islet-like-clusters (sc-ilcs)
*Purpose: Deceased donor allo-islet transplants (Tx) have demonstrated the ability of cell-based therapy to fully reverse T1D, however, an inadequate donor supply and frequent need…2021 American Transplant Congress
Portal Hypertension Abrogates Trail Expression of Liver Resident Nk Cells via Il-33
Hiroshima Uni., Hiroshima, Japan
*Purpose: Portal vein hypertension (PHT) is associated with poor prognosis, risk factors for small graft syndrome, bloodstream infection, and acute rejection after living donor liver…2021 American Transplant Congress
K562 Cells Expressing HLA-A2 Stimulate Alloreactive CD8+ T Cells
Emory Transplant Center, Emory University, Atlanta, GA
*Purpose: T cell-mediated rejection is a significant factor that leads to graft damage and loss in transplant recipients. Due to the complexity of the TCR:pMHC…2021 American Transplant Congress
Disparities in HLA Representation by Single Antigen Reagents in Different Ethnic Populations
1Keck School of Medicine of USC, Los Angeles, CA, 2Children's Hospital Los Angeles, Los Angeles, CA
*Purpose: It is not possible to test for antibodies against the antigens encoded by every HLA allele due to cost and throughput constraints. When alleles…2021 American Transplant Congress
Spleen Tyrosine Kinase (syk): A Novel Regulator of Neutrophil Infiltration in Hepatic Iri
Surgery, University of Florida, Gainesville, FL
*Purpose: Hepatic ischemia-reperfusion injury (IRI) plays a governing role in orthotopic liver transplantation, significantly impairing early graft function and increasing organ susceptibility to rejection. Neutrophil…2021 American Transplant Congress
The Contribution of Disulfide-hmgb1 Released During Ischemia-reperfusion Injury to Pro-inflammatory Macrophage Polarization Following Liver Transplantation
Pathology and Lab Medicine, UCLA, Los Angeles, CA
*Purpose: Ischemia-reperfusion injury (IRI) during liver transplantation (LT) is a pro-inflammatory response linked to poorer outcomes, including increased alloimmunity, post-LT. We previously showed that post-reperfusion…
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