Am J Transplant, Volume 21, Suppl 3 Archives - Page 63 of 139 - ATC Abstracts

2021 American Transplant Congress
Tacrolimus Therapeutic Exposure is Not Consistently Predicted by Target Troughs or CYP3A5 Variants in Stable Renal Transplant Recipients
K. Tornatore¹, K. Attwood², D. Brazeau³, B. Murray⁴
¹Pharmacy Practice, School of Pharmacy; University at Buffalo, Buffalo, NY, ²Biostatistics, School of Public Health; University at Buffalo, Buffalo, NY, ³Pharmacy Practice, School of Pharmacy; Marshall University, Huntington, WV, ⁴Medicine, Erie County Medical Center Corp., Buffalo, NY
*Purpose: Tacrolimus (TAC) immunosuppression requires therapeutic trough monitoring post-transplant due to notable interpatient pharmacokinetic(PK) variability which may be attributed to CYP3A5 polymorphisms. We investigated the…
2021 American Transplant Congress
Overall Survival by Best Overall Response with Tabelecleucel in Patients with Epstein-Barr Virus-Driven Post-Transplant Lymphoproliferative Disease After Solid Organ Transplant
S. Prockop¹, L. Gamelin², R. Dinavahi², Y. Sun², N. Guzman-Becerra², H. Parmar²
¹Memorial Sloan Kettering Cancer Center, New York, NY, ²Atara Biotherapeutics, South San Francisco, CA
*Purpose: Tabelecleucel is an investigational, off-the-shelf, allogeneic Epstein-Barr virus (EBV)-specific T-cell immunotherapy being studied in patients (pts) with serious EBV-driven diseases, including post-transplant lymphoproliferative disease…
2021 American Transplant Congress
Blood Type A2/a2b to B Renal Transplantation: A Single Center Retrospective Cohort Study
V. S. Tatapudi, N. Alnazari, R. Chand, N. M. Ali, B. E. Lonze, R. A. Montgomery
NYU Langone Transplant Institute, NYU Langone Health, New York, NY
*Purpose: Blood type B candidates on the deceased donor kidney waitlist have a lower transplantation rate and longer wait time than candidates of other blood…
2021 American Transplant Congress
Outcomes of Abdominal Transplant Recipients Who Receive Organs from Donors with Positive Cultures
A. Perez Cortes Villalobos, A. Humar, D. Kumar
University Health Network, Toronto, ON, Canada
*Purpose: Due to limited organ availability, use of donors with positive bacterial cultures is common practice. One of the main concerns is transmission to the…
2021 American Transplant Congress
Recipient Selector for Donation After Cardiac Death Allografts
G. Handing¹, S. Ganni², S. Barrett¹, N. Galvan², C. O’Mahony², J. Goss², R. Cotton², A. Rana²
¹School of Medicine, Baylor College of Medicine, Houston, TX, ²Michael E DeBakey Department of Surgery, Division of Abdominal Transplant, Houston, TX
*Purpose: Donation after cardiac death (DCD) allografts might represent one of the largest untapped sources of liver allografts. Our aim was to identify independent donor…
2021 American Transplant Congress
Accelerated Bronchiolitis Obliterans After Lung Transplant Promoted by an ATG16L1 Mutation is Coupled to Mitochondrial Damage and Metabolic Alterations in Monocyte-derived Antigen Presenting Cells
M. Cano¹, D. Zhou¹, D. Kreisel¹, C. Chen², K. Pugh¹, D. Byers¹, R. Hachem¹, A. Gelman¹
¹Washington University, Saint Louis, MO, ²UT Southwestern Medical Center, Dallas, TX
*Purpose: Bronchiolitis obliterans (BOS) remains a major cause of death for lung transplant recipients, and the mechanisms that drive BOS remain poorly understood. It is…
2021 American Transplant Congress
Characterization of Retransplantation Following Graft Failure Due to Bkvn
K. Nguyen¹, H. Curtis², J. Panichella², H. Resweber³, A. Di Carlo², S. Karhadkar¹
¹Surgery, Temple University School of Medicine, Philadelphia, PA, ²Surgery, Temple University School of Medicine, Philadephia, PA, ³Surgery, Temple University School of Medicine, Gladwyne, PA
*Purpose: Immunosuppression following kidney transplantation allows for the reactivation of BK polyomavirus (BKV)- frequently implicated in graft dysfunction and failure. Although BKV Nephropathy (BKVN) was…
2021 American Transplant Congress
Age and Racial Disparities in Access to Re-kidney Transplantation
S. S. Patole¹, J. Ahn¹, S. Sandal², D. Segev¹, M. McAdams Demarco³
¹Department of Transplantation Surgery, Johns Hopkins School of Medicine, Baltimore, MD, ²McGill University, Montreal, QC, Canada, ³Department of Epidemiology, Johns Hopkins School of Medicine, Baltimore, MD
*Purpose: Graft failure is likely increasing among kidney transplant (KT) recipients due to improvements in patient survival. While the benefits of re-KT have been well…
2021 American Transplant Congress
Comprehensive Utilization of HCV Viremic and Non-Viremic Donor Livers and Kidneys into HCV-negative Patients
M. E. de Vera, J. Woloszyn, J. Sterris, M. Robinson, R. Evans, S. Blais, B. Elhazin, C. Amador, c. Berk, M. Volk, R. Villicana
Transplant Institute, Loma Linda University Health, San Bernardino, CA
*Purpose: We report our experience on virologic and graft outcomes of HCV-negative patients transplanted with HCV NAT+ (viremic) and HCV Ab+/NAT- (non-viremic) livers and kidneys…
2021 American Transplant Congress
Adenovirus-Specific T Cells for Steering of Immunosuppression After Pediatric Kidney Transplantation in the Randomized Controlled Ivist Trial
T. Ahlenstiel-Grunow¹, X. Liu², R. Schild³, J. Oh³, C. Taylan⁴, L. T. Weber⁴, H. Staude⁵, M. Verboom⁶, C. Schröder⁷, R. Sabau⁷, A. Großhennig², L. Pape¹
¹Pediatrics II, University Hospital of Essen, Essen, Germany, ²Institute of Biostatistics, Hannover Medical School, Hannover, Germany, ³Pediatric Nephrology, University Hospital Hamburg-Eppendorf, Hamburg, Germany, ⁴Pediatric Nephrology, University of Colgne, Köln, Germany, ⁵Pediatric Nephrology, University Hospital of Rostock, Rostock, Germany, ⁶Institute of Transfusion Medicine and Transplant Engineering, Hannover Medical School, Hannover, Germany, ⁷Institute for Clinical Pharmacology, Hannover Medical School, Hannover, Germany
*Purpose: Pharmacokinetic monitoring alone is insufficient to estimate the intensity of immunosuppression after pediatric kidney transplantation (Tx). Levels of virus-specific T cells (Tvis) have been…