Am J Transplant, Volume 21, Suppl 3 Archives - Page 59 of 139 - ATC Abstracts

2021 American Transplant Congress
Lung Transplant Recipients Developing Early DSAs are Characterized by a Shift Towards Memory B Cells Directly After Transplantation
S. Christoph¹, A. Hitz¹, R. Bellmàs Sanz¹, J. Kühne¹, B. Wiegmann², F. Ius², J. Salman², E. Chichelnitskiy¹, T. Siemeni², W. Sommer³, A. Haverich², G. Warnecke³, C. Falk¹
¹Institute of Transplant Immunology, MHH, Hannover, Germany, ²Department of Cardiothoracic, Transplant and Vascular Surgery, MHH, Hannover, Germany, ³Department of Cardiac Surgery, University Hospital Heidelberg, Heidelberg, Germany
*Purpose: After lung transplantation (LTx), the development of early donor HLA-specific antibodies (eDSA) is associated with antibody-mediated rejection (AMR) and poor graft survival. Since 2013,…
2021 American Transplant Congress
Patterns and Inhibition of Cell Death During Static Cold Storage of Human Kidneys
J. R. DiRito¹, G. Chickering², J. T. Langford¹, D. Stern¹, S. Hosgood³, M. L. Nicholson³, E. Gavathiotis⁴, R. N. Kitsis⁵, M. Saltzman², J. S. Pober⁶, G. T. Tietjen⁷
¹Surgery, Yale School of Medicine, New Haven, CT, ²Biomedical Engineering, Yale University, New Haven, CT, ³Surgery, University of Cambridge, Cambridge, United Kingdom, ⁴Biochemistry and Medicine, Wilf Family Cardiovascular Research Institute, Albert Einstein College of Medicine, Bronx, NY, ⁵Surgery, Albert Einstein College of Medicine, Bronx, NY, ⁶Immunobiology, Yale University, New Haven, CT, ⁷Surgery and Biomedical Engineering, Yale School of Medicine, New Haven, CT
*Purpose: As the donor population continues to age and accumulate co-morbidities, more marginal kidneys are being retrieved for transplantation. However, estimates suggest that more than…
2021 American Transplant Congress
Microbial Signatures Promote Antibiotic-Mediated Alleviation of Peritransplant Liver Damage in Mouse Recipients
K. J. Dery¹, S. Kageyama¹, H. Hirao¹, H. Kojima¹, K. Kadono¹, T. Dong², J. W. Kupiec-Weglinski¹
¹The Dumont-UCLA Transplantation Center, Los Angeles, CA, ²Department of Medicine, Vatche & Tamar Manoukian Division of Digestive Diseases, UCLA, Los Angeles, CA
*Purpose: Although recent evidence shows that modifications of gut microbiota by antibiotics (Abx) influences liver allograft function, its compositional role in orthotopic liver transplantation (OLT)…
2021 American Transplant Congress
The Absence of T Follicular Regulatory Cells Prolongs Germinal Center Reactivity in Transplantation
E. S. Crichton, S. Zeng, I. Badell
Emory University, Atlanta, GA
*Purpose: Deleterious alloantibodies result from T follicular helper (Tfh) cell-driven germinal center (GC) reactivity. T follicular regulatory (Tfr) cells are a subset of regulatory T…
2021 American Transplant Congress
Estrogen Receptors Alpha and Beta are Required for Immune Homeostasis and Normal Treg Function
L. M. Christensen¹, T. Akimova², G. Ge³, R. Han¹, L. Wang¹, P. Hernandez³, C. O'Brien³, M. H. Levine³, W. W. Hancock¹
¹Children's Hospital of Philadelphia, Philadelphia, PA, ²Children's Hospital of Philadelphia and University of Pennsylvania, Philadelphia, PA, ³University of Pennsylvania, Philadelphia, PA
*Purpose: Estrogen signaling is a critical component of mammalian homeostasis, acting through a complex and interconnected system of hormone synthesis pathways and receptor signaling cascades.…
2021 American Transplant Congress
Bone Marrow-Derived Mesenchymal Stem Cells Improve Rat Islet Graft Revascularization by Upregulating Isl1
W. Ying, J. Wang, X. Ding
Kidney Transplantation, The First Affiliated Hospital of Xi'an Jiaotong University, Xi An, China
*Purpose: Revascularization of the transplant islet is a crucial step that defines the success rate of patient recovery. Though bone marrow-derived mesenchymal stem cells (BMSCs)…
2021 American Transplant Congress
Nanodiamond-doxorubicin Complexes Improve Hepatic Ischemia/reperfusion Injury
A. Kobayashi, C. Grady, S. Duarte, V. Boominathan, S. Shrestha, A. Zarrinpar
Surgery, University of Florida, Gainesville, FL
*Purpose: Hepatic ischemia/reperfusion injury (IRI) is a major inflammatory event in liver transplantation that is mediated by oxidative stress. Doxorubicin (DOX) can mitigate oxidative stress…
2021 American Transplant Congress
The Inflammatory Response in the Context of Tissue Injury: Roles of Tyro3, Axl, and Mer (TAM) Receptor Tyrosine Kinases in Liver Ischemia/reperfusion Injury
J. Zhang¹, H. Zhang¹, M. Ni², R. Busuttil¹, J. Kupiec-Weglinski¹, Y. Zhai¹
¹Dumont-UCLA Transplant Center, Los Angeles, CA, ²Liver Suyrgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
*Purpose: Although the inflammatory response in liver ischemia reperfusion injury has been studied extensively, how the context of tissue injury (presence of necrotic/apoptotic cells) regulates…
2021 American Transplant Congress
Single Center Experience Comparing Two Clinically Available Donor Derived Cell Free DNA Tests
S. Bunnapradist¹, S. Lee², P. Homkrailas³, G. Danovitch³
¹UCLA, Los Angeles, CA, ²Pharmacy, David Geffen School of Medicine at UCLA, Los Angeles, CA, ³David Geffen School of Medicine at UCLA, Los Angeles, CA
*Purpose: Donor derived cell-free DNA (dd cf-DNA), this new technology allows for non-invasive monitoring of graft function. Two most commonly used assays are Prospera (Natera®,…
2021 American Transplant Congress
RNA Sequencing (RNAseq) Tissue Analysis Can Provide Early Warning Signals for Potential Intestinal Transplant Complications
J. Kang¹, L. Belyayev¹, O. Aguirre¹, K. Khan¹, Y. Gusev², K. Bhuvaneshwar², H. Ressom³, J. Hawksworth¹, C. Matsumoto¹, T. Fishbein¹, A. Kroemer¹
¹MedStar Georgetown Transplant Institute, Washington, DC, ²Georgetown University Medical Center, Innovation Center for Biomedical Informatics, Washington, DC, ³Georgetown University Medical Center, Lombardi Comprehensive Cancer Center, Washington, DC
*Purpose: A disrupted mucosal barrier in intestinal grafts can cause alloreactive complications such as rejection, inflammation and infection following intestinal transplantation (ITx). We hypothesize that…