Am J Transplant, Volume 21, Suppl 3 Archives - Page 54 of 139 - ATC Abstracts

2021 American Transplant Congress
Pharmacokinetic Analysis of Direct Acting Antiviral Use on Weight-Adjusted FK506 Trough/dose Ratios in Obese Kidney Transplant Recipients
A. Demirag¹, P. L. Lobo², J. Oberholzer¹, A. Kumar², B. Rawashdeh¹, S. L. Lennon¹, H. N. Guvener Demirag¹, A. Doyle², J. Geystone³, K. L. Brayman¹
¹Transplantation, University of Virginia Medical Center, Charlottesville, VA, ²Transplantation Nephrology, University of Virginia Medical Center, Charlottesville, VA, ³Clinical Pharmacy, University of Virginia Medical Center, Charlottesville, VA
*Purpose: Using hepatitis C viremic (HCV) organs in kidney transplant recipients(KTRs) is very important to decrease the number of patients on the waiting list. Direct…
2021 American Transplant Congress
The Benefits of Sharing Non-Directed Donors Nationally Through Paired Exchange
J. Verbesey¹, A. G. Thomas², A. D. Waterman³, J. Vucci¹, G. Vranic¹, A. Gilbert¹, S. Ghasemian¹, M. Cooper¹
¹Georgetown University Hospital, Washington, DC, ²Johns Hopkins University School of Medicine, Baltimore, MD, ³UCLA, Los Angeles, CA
*Purpose: Non-directed donors (NDDs) are a valuable resource that can “unlock” incompatible transplants. Recent advances in paired kidney exchange (PKE) suggest that NDDs may facilitate…
2021 American Transplant Congress
The Unintended Financial Consequences of Acuity Circles for Liver Allocation – Two-fold Increase in Import Fees and Higher Organ Acquisition Cost Despite Unchanged Travel Patterns
A. Wall, S. Asrani, G. McKenna, E. Martinez, R. Ruiz, H. Fernandez, J. Bayer, A. Gupta, N. Onaca, R. Goldstein, J. Trotter, G. Testa
Abdominal Transplant Surgery, Baylor University Medical Center, Dallas, TX
*Purpose: The recent initiation of acuity circles (AC) as the basis for liver allocation is associated with broader sharing and potentially greater travel and increased…
2021 American Transplant Congress
Managing the Significant Drug-Drug Interaction Between Tacrolimus and Letermovir in Solid Organ Transplant Recipients
J. Hedvat, J. Choe, D. Salerno, J. Scheffert, D. Bley, A. Anamisis, T. Shertel, J. Lee, E. Liu, N. W. Lange
NewYork-Presbyterian Hospital, New York, NY
*Purpose: Letermovir does not appear to share cross-resistance with ganciclovir and is not associated with nephrotoxicity or myelosuppressive effects, making it an attractive option for…
2021 American Transplant Congress
Lung Transplant Recipients with Severe Acute Respiratory Syndrome-Coronavirus 2 Infection and Asymptomatic Carriers Waiting for Lung Transplantation Induce Circulating Exosomes with Severe Acute Respiratory Syndrome-Coronavirus 2 Spike Protein S2
S. Bansal, S. Tokman, T. Fleming, M. Smith, R. Bremner, T. Mohanakumar
St. Joseph’s Hospital and Medical Center, Phoenix, AZ
*Purpose: Exosomes are vesicles released by cells into body fluids. We demonstrated increased circulating exosomes with lung self-antigens (Collagen V, Kα1 Tubulin) and viral antigens…
2021 American Transplant Congress
Cd4 T Cells Can Trigger Nk-dependent Chronic Rejection Independent of Antibodies
R. G. Gill¹, B. Mehrad², C. M. Lin²
¹Surgery, University of Colorado Denver, Aurora, CO, ²Medicine, University of Florida, Gainesville, FL
*Purpose: In transplantation, recipient CD4+ T cells have two potential means of MHC class II-restricted donor antigen detection: (1) the direct recognition of allogeneic MHC…
2021 American Transplant Congress
Impact of a Cmv Cell Mediated Immunity Based Protocol on Guiding Cmv Prophylaxis Following Pediatric Liver Transplantation – A Single Center Experience
G. Kalkan¹, S. Ball², L. McConnell², D. M. Desai³, A. Aqul³, P. K. Sue¹
¹Infectious Disease, University of Texas Southwestern Medical Center, Dallas, TX, ²Solid Organ Transplant Program, Children's Health, Dallas, TX, ³Solid Organ Transplant Program, University of Texas Southwestern Medical Center, Dallas, TX
*Purpose: Cytomegalovirus (CMV) is an important cause of morbidity following pediatric orthotopic liver transplantation (OLT), especially among high risk (HR) CMV D+/R- recipients. In 2019,…
2021 American Transplant Congress
Coronary Computed Tomography Angiography for Pre-Liver Transplant Cardiovascular Risk Assessment: A Single Center Experience
J. Rice¹, T. Genders², D. Groves², J. R. Burton¹, J. Moloo², R. Quaife², D. Vargas³, M. Kriss¹
¹Division of Gastroenterology and Hepatology, University of Colorado, Aurora, CO, ²Division of Cardiology, University of Colorado, Aurora, CO, ³Division of Radiology, University of Colorado, Aurora, CO
*Purpose: Coronary computed tomography angiography (CCTA) is an established non-invasive imaging modality for diagnosing coronary artery disease (CAD), though its use for cardiovascular disease (CVD)…
2021 American Transplant Congress
Donor Mhc-independent Islet Rejection in Autoimmune Diabetes: Implications for Stem Cell Therapy
R. G. Gill¹, M. Coulombe², K. S. Beard¹, A. L. Burrack³
¹University of Colorado, Aurora, CO, ²Surgery, University of Colorado, Aurora, CO, ³Mircrobiology and Immunology, University of Minnesota, Minneapolis, MN
*Purpose: Stem cell technology is an attractive approach for generating insulin-producing cells for transplantation in insulin-dependent diabetes and potentially can be genetically modified. One recent…
2021 American Transplant Congress
Donor-Derived Cell-Free DNA Levels Risk-Stratify Polyoma BK Viremia and Associated Clinical Events After Kidney Transplantation – Preliminary Results from ADMIRAL Study
A. Pai¹, L. Bu², J. S. Bromberg³, G. Gupta⁴, I. Moinuddin⁴, T. Alhamad⁵, V. Bowers⁶, S. Ghosh⁷, W. Tian⁷, E. Stites⁸, S. Anand⁹
¹University of Texas McGovern Medical School, Houston, TX, ²University of Minnesota, Minneapolis, MN, ³University of Maryland School of Medicine, Baltimore, MD, ⁴Virginia Commonwealth University, Richmond, VA, ⁵Washington University in St. Louis, St. Louis, MO, ⁶Tampa General Hospital, Tampa, FL, ⁷CareDx, Brisbane, CA, ⁸University of Colorado, Aurora, CO, ⁹Intermountain Medical Center, Murray, UT
*Purpose: The threshold of 10,000 copies for blood Quant BK PCR has been used as a surrogate for BK nephropathy (BKN) in kidney transplant recipients…