2021 American Transplant Congress
Myeloid YAP-HSF1 Signaling Inhibits NLRP3 Function and RIPK3-mediated Hepatocyte Necroptosis in Liver Ischemia and Reperfusion Injury
Surgery, Dumont - UCLA Transplant Ctr, Los Angeles, CA
*Purpose: Yes-associated protein (YAP), a downstream effector of the Hippo pathway, tightly regulates cell growth, survival, and tissue inflammation. Activation of heat shock factor 1…2021 American Transplant Congress
Nrf2 Assessment in Discarded Liver Allografts: A Role in Allograft Function and Salvage
Surgery, Washington University School of Medicine, Saint Louis, MO
*Purpose: With mounting pressures to optimize organ availability for transplantation, there is a focus on reducing organ discard and attempting to resuscitate declined grafts for…2021 American Transplant Congress
Real-time Donor-derived Cell-free Dna Kinetics Indicate Decreased “Molecular Injury” During Treatment of Acute Renal Allograft Rejection
*Purpose: Dd-cfDNA is a validated plasma analyte (t½~30 min) for surveillance of renal transplant (KT) rejection with limited reports characterizing response to acute allograft rejection…2021 American Transplant Congress
Dysregulation of Immune Cell Glycolysis and Oxidative Phosphorylation Correlates with Development of Pre-liver Transplant Immune Dysfunction and Post-transplant Mortality
*Purpose: Cirrhosis-related immune dysfunction contributes to early morbidity and mortality following liver transplant (LT). We have previously identified a pre-LT biomarker panel, the immune frailty…2021 American Transplant Congress
Trugraf Gene Expression Testing Can Discriminate Rejection in the Setting of Acute Kidney Injury
*Purpose: The TruGraf kidney blood gene expression test is a well-validated non-invasive biomarker to detect immune quiescence thus ruling out silent subclinical rejection in stable…2021 American Transplant Congress
Inducing Transient Mixed Chimerism without Chimeric Transition Syndrome for Tolerance Induction After Kidney Transplantation
Samsung Medical Center, Seoul, Korea, Republic of
*Purpose: Immunological or operational tolerance, defined as the absence of a destructive immune response to a transplanted tissue without ongoing immunosuppression, is one strategy that…2021 American Transplant Congress
The Perfect Candidate? The Stanford Integrated Psychosocial Assessment for Transplant
*Purpose: The Stanford Integrated Psychosocial Assessment for Transplant (SIPAT) is a tool used to objectify and enhance the pre-transplant psychosocial evaluation. We sought to assess…2021 American Transplant Congress
Practice Patterns in Pneumocystis Jirovecii Pneumonia Prophylaxis in Solid Organ and Bone Marrow Transplant Recipients
NYU Langone Transplant Institute, New York, NY
*Purpose: Trimethoprim-sulfamethoxazole (TMP-SMX) is the preferred agent for pneumocystis jirovecii pneumonia (PJP) prophylaxis in solid organ transplant (SOT) and bone marrow transplant (BMT); however, adverse…2021 American Transplant Congress
Covid-19 in a Kidney Transplant Patient Associated with Collapsing Glomerulopathy
Washington University School of Medicine, St. Louis, MO
*Purpose: Coronavirus- 19 is a novel virus with various clinical presentations ranging from a cold to severe acute respiratory syndrome. However, little is known about…2021 American Transplant Congress
Beta-lactam Allergies Among Solid Organ Transplant Recipients: Prevalence and Association with Transplant Admission Length of Stay
*Purpose: Previous studies have identified that 14-27% of solid organ transplant (SOT) recipients report a beta lactam allergy (BLA). Patients with BLAs often receive less…
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