Am J Transplant, Volume 21, Suppl 3 Archives - Page 47 of 139 - ATC Abstracts

2021 American Transplant Congress
High Donor-Derived Cell-Free DNA Levels Predict Development of De Novo HLA Donor-Specific Antibodies After Kidney Transplantation – Data from the ADMIRAL Study
G. Gupta¹, T. Alhamad², V. Bowers³, I. Moinuddin¹, S. Ghosh⁴, J. Zeng⁴, E. Stites⁵, A. Pai⁶, J. S. Bromberg⁷, S. Anand⁸
¹Virginia Commonwealth University, Richmond, VA, ²Washington University in St. Louis, St. Louis, MO, ³Tampa General Hospital, Tampa, FL, ⁴CareDx, Brisbane, CA, ⁵University of Colorado, Aurora, CO, ⁶University of Texas McGovern Medical School, Houston, TX, ⁷University of Maryland School of Medicine, Baltimore, MD, ⁸Intermountain Medical Center, Murray, UT
*Purpose: Donor-derived cell-free DNA (dd-cfDNA) as a marker of injury can serve to quantify subclinical inflammation and molecular injury. As the release of graft genomic…
2021 American Transplant Congress
Molecular Assessment of Fibrosis and Steatohepatitis in the INTERLIVER Study
K. S. Madill-Thomsen¹, P. F. Halloran¹, &. the INTERLIVER Study Group²
¹Alberta Transplant Applied Genomics Centre, Edmonton, AB, Canada, ²., ., AB, Canada
*Purpose: We previously reported a molecular system for assessing rejection in liver transplants and recently expanded this system to assess injury. Fibrosis is associated with…
2021 American Transplant Congress
Single Cell Analysis of Living Donor Kidneys Reveals Sex-based Diversity in Proximal Tubulargene Expression
C. M. McEvoy¹, J. M. Szusz², S. Clotet-Freixas¹, J. An², S. MacParland², G. Bader³, S. Q. Crome², A. Konvalinka¹
¹Ajmera Transplant Centre, Toronto General Hospital Research Institute, Toronto, ON, Canada, ²Immunology and Molecular Genetics, University of Toronto, Toronto General Hospital Research Institute, Toronto, ON, Canada, ³Donnolly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, Canada
*Purpose: Males with chronic kidney disease (CKD) experience a more rapid decline in kidney function and progression to end-stage kidney disease than females. In vitro…
2021 American Transplant Congress
Living Donor Kidney Transplantation Racial Disparities Persist Independent of Social Vulnerability
A. C. Killian¹, M. C. McLeod¹, B. Shelton¹, R. D. Reed¹, P. MacLennan¹, H. Qu¹, B. J. Orandi¹, V. Kumar¹, D. Sawinski², R. M. Cannon¹, D. J. Anderson¹, M. J. Hanaway¹, J. E. Locke¹
¹University of Alabama at Birmingham Hospital, Birmingham, AL, ²Hospital of the University of Pennsylvania, Philadelphia, PA
*Purpose: Living donor kidney transplantation (LDKT) confers a significant survival benefit over deceased donor transplantation. Racial disparities in access to LDKT are well recognized, yet…
2021 American Transplant Congress
Addressing a Need in Transplant Clinical Care: Creation of the Organ Transplant Caregiver Toolkit
H. Bruschwein¹, G. Chen², A. Ortega³, W. Balliet⁴, T. Coco⁵, C. Thomas⁶, B. Hansen⁵, D. Richardson⁷, K. Canavan⁸, C. Burch⁹, A. Yaldo¹⁰, M. Jesse¹¹
¹University of Virginia School of Medicine, Charlottesville, VA, ²Memorial Hermann Transplant Center, Houston, TX, ³Memorial Transplant Institute, Miami, FL, ⁴Medical University of South Carolina, Charleston, SC, ⁵Mayo Clinic, Pheonix, AZ, ⁶Banner Transplant Institute, Pheonix, AZ, ⁷Caregiver, Minburn, IA, ⁸National Kidney Foundation, New York, NY, ⁹Stanford Children's Hospital, Palo Alto, CA, ¹⁰University of Michigan, Ann Arbor, MI, ¹¹Henry Ford Transplant Institute, Detroit, MI
*Purpose: Lay or informal caregivers are a critical component of pre- and post-operative care in adult organ transplantation and living donation. Caregiving in organ transplantation…
2021 American Transplant Congress
Allograft Function and Baseline Donor Derived Cell Free DNA in Kidney Transplant Recipients: One Size Doesn’t Fit All
K. K. Sureshkumar, A. Grazier, B. Chopra
Allegheny General Hospital, Allegheny Health Network, Pittsburgh, PA
*Purpose: Donor derived cell free DNA (dd-cfDNA) is increasingly used to predict acute rejection in kidney allografts . Cell free DNA fragments are constantly released…
2021 American Transplant Congress
Video Virtual Transplant Evaluation and Listing
V. Casingal¹, B. Thrasher², J. Brown², C. Fotiadis²
¹Department of Surgery, Atrium Health, Charlotte, NC, ²Department of Transplant, Atrium Health, Charlotte, NC
*Purpose: Due to the COVID-19 pandemic, many hospitals suspended in person evaluations of kidney transplants during the March-April time period of 2020. State and local…
2021 American Transplant Congress
Value of a Personal Systems Approach in Improving Medication Adherence in Adult Kidney Transplant Patients: A Cost-effectiveness Analysis of the MAGIC Randomized Clinical Trial
M. R. Wakefield¹, M. Whittington², C. Ashbaugh³, L. M. Remy⁴, D. Aholt⁴, C. Miller⁴, D. Hathaway⁵, D. Clark⁵, K. Goggin⁵, R. J. Ellis⁶, C. L. Russell⁴
¹Surgery/Urology, University of Missouri School of Medicine, Columbia, MO, ²University of Kansas Medical Center, Kansas City, KS, ³University of Missouri Health Care, Columbia, MO, ⁴University of Missouri-Kansas City, Kansas City, MO, ⁵Children's Mercy Kansas City, Kansas City, MO, ⁶Indiana University School of Nursing, Indianapolis, IN
*Purpose: The objective of this evaluation was to estimate the cost of implementation and the cost-effectiveness of a person-level intervention called SystemCHANGETM .*Methods: To estimate…
2021 American Transplant Congress
Re-Transplantation of Mouse Kidney Grafts to Study Local Immune Responses
D. Zhao, M. Oberbarnscheidt, F. Lakkis, K. Khodor
Starzl Transplantation Institution, Pittsburgh, PA
*Purpose: Mouse kidney transplantation has been widely used to study the immune response to allogeneic grafts. This response includes a circulating systemic compartment and a…
2021 American Transplant Congress
A Novel Mouse Model of Cardiac Allograft Vasculopathy
H. Tsuda¹, E. Reed², W. Baldwin¹, R. Fairchild¹
¹Inflammation and Immunity, Cleveland Clinic, Cleveland, OH, ²Pathology and Laboratory Medicine, University of California, Los Angeles, CA
*Purpose: Cardiac allograft vasculopathy (CAV) is a major long-term complication of heart transplantation and the presence of donor specific antibodies (DSA) is associated with an…