2021 American Transplant Congress
Use of Donor Blood Expedites HCV Genotyping and Allows Earlier DAA Initiation for Recipients of HCV+ Kidneys
Tranplant Institute, NYU Langone Health, New York, NY
*Purpose: Utilization of HCV viremic donor kidneys for transplant into HCV naïve recipients has become more widespread, yet best practices governing the initiation, timing or…2021 American Transplant Congress
Successful Long Term Survival of Vascularized Composite Allografts After Extended Preservation at Subzero Temperatures Using Bioinspired Next Generation Cryoprotectants
*Purpose: Vascularized composite allotransplantation (VCA) is a viable reconstructive option for patients with devastating tissue defects. However, the field is constrained by short tolerable ischemia…2021 American Transplant Congress
Liver Transplantation for COVID-19-associated Cholangiopathy
*Purpose: The hallmark viral pneumonia of coronavirus-19-disease (COVID-19) is often accompanied by important extra-pulmonary manifestations. Liver dysfunction occurs in up to 45% of COVID-19 patients,…2021 American Transplant Congress
Prevalence of Hepatitis E Virus Infection in Solid Organ Transplant Recipients: A Systematic Review and Meta-analysis
*Purpose: Hepatitis E virus (HEV) infection is an underdiagnosed disease due to the use of serological assays with low sensitivity. Although most patients with HEV…2021 American Transplant Congress
The Implementation of the New Unos Policy That Relegates C-peptide and Body Mass Index Criteria Has Resulted in Shifting Recipient Demographics
Montefiore Medical Center, Bronx, NY
*Purpose: Waitlist time accrual for SPK was previously limited to candidates on insulin that had either a c-peptide ≤ 2 ng/ml, or a c-peptide >…2021 American Transplant Congress
The Efficacy of Delayed Fc-nonbinding Anti-CD3 Antibody Treatment in Sensitized Allogeneic Mouse Heart Transplantation
*Purpose: Delayed treatment with Fc-nonbinding anti-CD3 antibody (ab) permits early graft infiltrating cells to promotes a transplant tolerance. However, graft infiltrating cells immediate after transplantation…2021 American Transplant Congress
Suppression of T Cell Proliferation by Activated Nonhuman Primate B Cells
Massachusetts General Hospital, Boston, MA
*Purpose: We previously generated Toll-like receptor (TLR)-activated B cells in rodent settings. These B cells can suppress T cell proliferation via in vitro mixed lymphocytes…2021 American Transplant Congress
Platelets Stimulate Liver Regeneration After Partial Liver Transplantation
GI and HBP Surgery, University of Tsukuba, Tsukuba, Japan
*Purpose: Living donor liver transplant (LDLT) can sometimes be associated with impaired regeneration and severe ischemia/reperfusion (I/R) injury in the liver graft, resulting in small-for-size…2021 American Transplant Congress
Adjuvant Treatment Shapes the Bone Marrow Myeloid Compartment Towards an Immunosuppressive Phenotype That Can Suppress Allograft Rejection
*Purpose: Myeloid derived suppressor cells (MDSCs) expand in response to inflammatory stimuli and have been shown to suppress adaptive immunity. Preliminary data from our lab…2021 American Transplant Congress
Single Cell RNAq-seq Analysis of Paired Peripheral and Intragraft T Cells Reveals Biopsy Specific Fc Receptor Gene Expression in Rejection Only
Washington University School of Medicine, St Louis, MO
*Purpose: Antibody mediated rejection (AMR) remains one of the major causes of allograft failure and our understanding of this disease process is poor. Transcriptomics studies…
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