Am J Transplant, Volume 21, Suppl 3 Archives - Page 39 of 139 - ATC Abstracts

2021 American Transplant Congress
Creating Efficiency in the Kidney Transplant Listing: Can We Streamline Candidate Ineligibility?
A. Vijay, N. Langford, K. Atiemo, S. Giusti, M. Killackey, H. Jeon, A. S. Paramesh
Tulane Abdominal Transplant Institute, New Orleans, LA
*Purpose: Evaluation of multiple transplant candidate referrals is a resource-intensive process that may delay listing and eventually transplanting appropriate patients. In this study, we sought…
2021 American Transplant Congress
Inhibition of Fatty Acid Beta-Oxidation Prolongs Heart Allograft Survival
B. W. Wong, Y. Zhu, H. Dun, L. Ye
Surgery, Washington University School of Medicine, Saint Louis, MO
*Purpose: To test the therapeutic efficacy of pharmacological inhibition of fatty acid beta-oxidation (FAO) on acute heart allograft survival.*Methods: We used a heterotopic Balb/c donor…
2021 American Transplant Congress
Development of a Rat Model of Antibody-Mediated Rejection After Liver Transplantation
T. Tajima, K. Hata, J. Kusakabe, H. Miyauchi, S. Uemoto
Dept. of Surgery, Div. of HBP Surgery & Transplantation, Kyoto University Graduate School of Medicine, Kyoto, Japan
*Purpose: Antibody-mediated rejection (AMR) is a refractory rejection after donor-specific antibody (DSA)-positive or ABO blood-type incompatible liver transplantation (LT), due at least in part to…
2021 American Transplant Congress
Human Liver-derived Mesenchymal Stromal Cells (MSC) are Superior Inhibitors of Natural Killer Cells Compared to Bone Marrow or Adipose Tissue-derived MSC
F. Yigitbilek, M. J. Hansen, W. D. Park, M. D. Stegall, T. Taner
Mayo Clinic, Rochester, MN
*Purpose: Guided by the liver allografts’ unique tolerogenic microenvironment and the immunoprotective impact on simultaneously transplanted organs, we recently isolated liver mesenchymal stromal cells (L-MSC)…
2021 American Transplant Congress
Taurodeoxycholic Acid and L-valine Ameliorate Macrophage Driven Alloimmunity in Obese Transplant Recipients
M. Quante¹, J. Iske¹, D. Perkins², M. Alegre³, H. Zhou¹, A. Elkhal¹, S. G. Tullius¹
¹Department of Surgery, Brigham and Women's Hospital, Boston, MA, ²University of Illinois at Chicago, Chicago, IL, ³Department of Medicine, The University of Chicago, Chicago, IL
*Purpose: Obesity initiates a chronic inflammatory network linked to more frequent perioperative complications and increased acute rejection rates after organ transplantation. Clinically, morbidly obese transplant…
2021 American Transplant Congress
CD80/PD-L1 Uniquely Regulates CD4 Effector T Cell Migration
W. Piao¹, L. Li¹, Y. Zhang², K. Hippen², M. WillsonShirkey¹, B. Blazar², L. Riella³, J. Bromberg¹
¹U Maryland, baltimore, MD, ²U Minnesota, Minneapolis, MN, ³Harvard U, boston, MA
*Purpose: CD80 is a costimulatory molecule expressed on antigen presenting cells (APCs) that binds CD28 and CTLA4, stimulating or inhibiting immunity, respectively. CD80 also binds…
2021 American Transplant Congress
HLA Mismatching and Subclinical Inflammation: An Association to be Considered in Kidney Transplant Patients with Low Immunological Risk
T. Vazquez-Sanchez¹, J. Alonso-Titos¹, P. Ruiz-Esteban¹, A. Caballero², M. Leon³, V. Lopez¹, E. Sola¹, D. Hernández¹
¹Nephrology, Instituto de Investigación Biomédica de Málaga (IBIMA). Hospital Universitario Regional de Málaga and University of Málaga. REDinREN (RD16/0009/0006). Málaga. (Spain), Málaga, Spain, ²Immunology, Instituto de Investigación Biomédica de Málaga (IBIMA). Hospital Universitario Regional de Málaga and University of Málaga. REDinREN (RD16/0009/0006). Málaga. (Spain), Málaga, Spain, ³Pathology, Instituto de Investigación Biomédica de Málaga (IBIMA). Hospital Universitario Regional de Málaga and University of Málaga. REDinREN (RD16/0009/0006). Málaga. (Spain), Málaga, Spain
*Purpose: Subclinical inflammation (SCI) (
2021 American Transplant Congress
Sampling Renal Biopsies in Pre-Clinical Research for Comprehensive Assessment
C. M. Edwards¹, C. Albert², D. Stern¹, J. Langford¹, W. Day², J. R. DiRito¹, W. M. Saltzman², M. Kashgarian³, J. S. Pober⁴, G. T. Tietjen¹
¹Surgery, Yale School of Medicine, New Haven, CT, ²Biomedical Engineering, Yale School of Medicine, New Haven, CT, ³Pathology, Yale School of Medicine, New Haven, CT, ⁴Immunobiology, Yale School of Medicine, New Haven, CT
*Purpose: Previous literature has demonstrated that single biopsies are not representative of a whole kidney in clinical assessments. In this study we aimed to design…
2021 American Transplant Congress
Myeloid YAP-HSF1 Signaling Inhibits NLRP3 Function and RIPK3-mediated Hepatocyte Necroptosis in Liver Ischemia and Reperfusion Injury
Y. Tian, D. Xu, M. Sheng, Y. Zhan, Y. Lin, C. Li, A. J. Coito, R. W. Busuttil, D. G. Farmer, J. W. Kupiec-Weglinski, B. Ke
Surgery, Dumont - UCLA Transplant Ctr, Los Angeles, CA
*Purpose: Yes-associated protein (YAP), a downstream effector of the Hippo pathway, tightly regulates cell growth, survival, and tissue inflammation. Activation of heat shock factor 1…
2021 American Transplant Congress
Nrf2 Assessment in Discarded Liver Allografts: A Role in Allograft Function and Salvage
O. Ahmed, M. Xu, F. Zhou, A. N. Wein, G. Upadhya, Y. Lin, W. Chapman
Surgery, Washington University School of Medicine, Saint Louis, MO
*Purpose: With mounting pressures to optimize organ availability for transplantation, there is a focus on reducing organ discard and attempting to resuscitate declined grafts for…