ATC Abstracts

American Transplant Congress abstracts

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  • 2021 American Transplant Congress

    Psychosocial Determinants of Regimen Adherence Among Kidney Transplant Recipients

    A. Balakrishnan, S. Bailey, D. Mroczek, M. Serper, D. P. Ladner, M. S. Wolf

    Northwestern University, Chicago, IL

    *Purpose: There is increasing evidence suggesting a high prevalence of inadequate medication adherence among kidney transplant recipients (KTRs) and its subsequent consequences on health outcomes.…
  • 2021 American Transplant Congress

    The Australian and New Zealand Living Kidney Donor Profile Index

    G. L. Irish1, S. Chadban1, N. Boudville2, S. B. Campbell3, J. Kanellis4, P. A. Clayton1

    1Australian and New Zealand Dialysis and Transplant Registry, South Australian Health and Medical Research Institute, Adelaide, Australia, 2Medical School, University of Western Australia, Perth, Australia, 3Department of Nephrology, Princess Alexandra Hospital, Brisbane, Australia, 4Department of Nephrology, Monash Health, Melbourne, Australia

    *Purpose: Risk scores may aid risk quantification and decision-making in kidney transplantation. The Living Kidney Donor Profile Index (LKDPI) was developed to choose between living…
  • 2021 American Transplant Congress

    Assessing the Prevalence of Risk Factors for Osteoporosis and Rate of Screening by Dexa Scan in Patients Referred for Liver Transplant Evaluation

    A. France1, J. Kirk2, M. Dokus2, B. Al-Judaibi2, M. Laryea2

    1Department of Internal Medicine, University of Rochester Medical Center, Rochester, NY, 2Division of Gastroenterology and Hepatology, University of Rochester Medical Center, Rochester, NY

    *Purpose: Osteoporosis (OP) and fragility fractures are well-known complications of both chronic liver disease (CLD) and transplant, with a significant increase in the prevalence of…
  • 2021 American Transplant Congress

    The Effect of Acuity Circles on Deceased Donor Transplant and Offer Rates Across Meld and Exception Statuses

    A. Wey1, S. Noreen2, S. Gentry3, N. Salkowski1, M. Cafarella2, R. Hirose4, J. Trotter5, D. Segev6, A. Israni1, J. Snyder1, B. Kasiske1

    1SRTR, Minneapolis, MN, 2UNOS, Richmond, VA, 3USNA, Annapolis, MD, 4Univ of San Francisco, San Francisco, CA, 5BSW Health, Dallas, TX, 6Johns Hopkins, Baltimore, MD

    *Purpose: Acuity circles (AC) allocation was implemented on February 4, 2020. AC significantly changed the relative priority of candidates with allocation PELD/MELD scores of 29…
  • 2021 American Transplant Congress

    Environmental Factors That Shape T-cell Alloimmunity: Role of the Microbiome

    K. Janek1, J. H. Fechner1, R. A. Daley1, K. Krautkamer1, F. Rey2, J. D. Mezrich1

    1Surgery, University of Wisconsin School of Medicine & Public Health, Madison, WI, 2Bacteriology, University of Wisconsin, Madison, WI

    *Purpose: Unlike other types of immunity, T-cell alloimmune responses to mismatched MHC proteins do not need priming by a previous exposure. While genetic differences between…
  • 2021 American Transplant Congress

    Transgenic Beta-cell Cxcl12 Expression and Stem Cell Mobilization Synergize to Suppress Type 1 Diabetes

    D. A. Alagpulinsa, A. Jajoo, M. H. Chapin II, M. C. Poznansky

    Vaccine & Immunotherapy Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA

    *Purpose: Hematopoietic stem and progenitor cells (HSPCs) and regulatory T cells (Tregs) highly express CXCR4, the receptor for the CXCL12 chemokine. This keeps them predominantly…
  • 2021 American Transplant Congress

    HLA I Antibody-Activated Endothelium Polarized M2-Like Macrophages with Increased Efferocytic and Phagocytic Capacity

    J. Nevarez-Mejia1, X. Wei1, N. M. Valenzuela1, M. Rossetti1, H. Pickering1, G. A. Fishbein1, A. Mulder2, E. F. Reed1

    1Pathology and Laboratory Medicine, UCLA, Los Angeles, CA, 2Immunohematology and Blood Transfusion, LUMC, Leiden, Netherlands

    *Purpose: The role of intragraft macrophages (Mϕs) during antibody-mediated rejection (AMR) remains unclear. Anti-HLA Abs during AMR drives vascular inflammation as seen by monocyte recruitment…
  • 2021 American Transplant Congress

    Naïve Rhesus Monkey CD4+CD8loT Cells Comprise High Percentage of Memory T Cells with Strong Effector Function

    M. Kubo, K. Sasaki, A. P. Gutiérrez, L. Lu, V. Vujevich, A. W. Thomson, M. Ezzelarab

    Department of Surgery, University of Pittsburgh, PITTSBURGH, PA

    *Purpose: Human CD4+CD8loT cells have been reported in patients with organ allograft rejection. We evaluated the incidence, phenotype, and function of CD4+CD8loT cells in nonhuman…
  • 2021 American Transplant Congress

    Alloreactive Memory T Follicular Helper Cells Rapidly Differentiate Into Effectors Independent of B Cell Memory Following Retransplantation

    S. Zeng, E. S. Crichton, I. R. Badell

    Department of Surgery, Emory, Atlanta, GA

    *Purpose: Donor-directed HLA antibodies are an important cause of renal allograft injury, but effective therapeutic options to prevent or eliminate donor-specific antibodies (DSA) do not…
  • 2021 American Transplant Congress

    Islet Isograft Transplantation Improves Insulin Sensitivity in a Murine Model of Type 2 Diabetes

    S. Lim, M. Choi, M. Kim, Y. Wee, H. Kwon, C. Jung, Y. Kim, D. Han, S. Shin

    Asan Medical Center, Seoul, Songpa, Korea, Republic of

    *Purpose: Type 2 diabetes develops in the presence of chronic overnutrition and genetic susceptibility, and causes insulin resistance and relative insulin deficiency. We hypothesized that…
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