Am J Transplant, Volume 21, Suppl 3 Archives - Page 30 of 139 - ATC Abstracts

2021 American Transplant Congress
Psychosocial Determinants of Regimen Adherence Among Kidney Transplant Recipients
A. Balakrishnan, S. Bailey, D. Mroczek, M. Serper, D. P. Ladner, M. S. Wolf
Northwestern University, Chicago, IL
*Purpose: There is increasing evidence suggesting a high prevalence of inadequate medication adherence among kidney transplant recipients (KTRs) and its subsequent consequences on health outcomes.…
2021 American Transplant Congress
The Australian and New Zealand Living Kidney Donor Profile Index
G. L. Irish¹, S. Chadban¹, N. Boudville², S. B. Campbell³, J. Kanellis⁴, P. A. Clayton¹
¹Australian and New Zealand Dialysis and Transplant Registry, South Australian Health and Medical Research Institute, Adelaide, Australia, ²Medical School, University of Western Australia, Perth, Australia, ³Department of Nephrology, Princess Alexandra Hospital, Brisbane, Australia, ⁴Department of Nephrology, Monash Health, Melbourne, Australia
*Purpose: Risk scores may aid risk quantification and decision-making in kidney transplantation. The Living Kidney Donor Profile Index (LKDPI) was developed to choose between living…
2021 American Transplant Congress
Assessing the Prevalence of Risk Factors for Osteoporosis and Rate of Screening by Dexa Scan in Patients Referred for Liver Transplant Evaluation
A. France¹, J. Kirk², M. Dokus², B. Al-Judaibi², M. Laryea²
¹Department of Internal Medicine, University of Rochester Medical Center, Rochester, NY, ²Division of Gastroenterology and Hepatology, University of Rochester Medical Center, Rochester, NY
*Purpose: Osteoporosis (OP) and fragility fractures are well-known complications of both chronic liver disease (CLD) and transplant, with a significant increase in the prevalence of…
2021 American Transplant Congress
The Effect of Acuity Circles on Deceased Donor Transplant and Offer Rates Across Meld and Exception Statuses
A. Wey¹, S. Noreen², S. Gentry³, N. Salkowski¹, M. Cafarella², R. Hirose⁴, J. Trotter⁵, D. Segev⁶, A. Israni¹, J. Snyder¹, B. Kasiske¹
¹SRTR, Minneapolis, MN, ²UNOS, Richmond, VA, ³USNA, Annapolis, MD, ⁴Univ of San Francisco, San Francisco, CA, ⁵BSW Health, Dallas, TX, ⁶Johns Hopkins, Baltimore, MD
*Purpose: Acuity circles (AC) allocation was implemented on February 4, 2020. AC significantly changed the relative priority of candidates with allocation PELD/MELD scores of 29…
2021 American Transplant Congress
Environmental Factors That Shape T-cell Alloimmunity: Role of the Microbiome
K. Janek¹, J. H. Fechner¹, R. A. Daley¹, K. Krautkamer¹, F. Rey², J. D. Mezrich¹
¹Surgery, University of Wisconsin School of Medicine & Public Health, Madison, WI, ²Bacteriology, University of Wisconsin, Madison, WI
*Purpose: Unlike other types of immunity, T-cell alloimmune responses to mismatched MHC proteins do not need priming by a previous exposure. While genetic differences between…
2021 American Transplant Congress
Transgenic Beta-cell Cxcl12 Expression and Stem Cell Mobilization Synergize to Suppress Type 1 Diabetes
D. A. Alagpulinsa, A. Jajoo, M. H. Chapin II, M. C. Poznansky
Vaccine & Immunotherapy Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA
*Purpose: Hematopoietic stem and progenitor cells (HSPCs) and regulatory T cells (Tregs) highly express CXCR4, the receptor for the CXCL12 chemokine. This keeps them predominantly…
2021 American Transplant Congress
HLA I Antibody-Activated Endothelium Polarized M2-Like Macrophages with Increased Efferocytic and Phagocytic Capacity
J. Nevarez-Mejia¹, X. Wei¹, N. M. Valenzuela¹, M. Rossetti¹, H. Pickering¹, G. A. Fishbein¹, A. Mulder², E. F. Reed¹
¹Pathology and Laboratory Medicine, UCLA, Los Angeles, CA, ²Immunohematology and Blood Transfusion, LUMC, Leiden, Netherlands
*Purpose: The role of intragraft macrophages (Mϕs) during antibody-mediated rejection (AMR) remains unclear. Anti-HLA Abs during AMR drives vascular inflammation as seen by monocyte recruitment…
2021 American Transplant Congress
Naïve Rhesus Monkey CD4⁺CD8^loT Cells Comprise High Percentage of Memory T Cells with Strong Effector Function
M. Kubo, K. Sasaki, A. P. Gutiérrez, L. Lu, V. Vujevich, A. W. Thomson, M. Ezzelarab
Department of Surgery, University of Pittsburgh, PITTSBURGH, PA
*Purpose: Human CD4+CD8loT cells have been reported in patients with organ allograft rejection. We evaluated the incidence, phenotype, and function of CD4+CD8loT cells in nonhuman…
2021 American Transplant Congress
Alloreactive Memory T Follicular Helper Cells Rapidly Differentiate Into Effectors Independent of B Cell Memory Following Retransplantation
S. Zeng, E. S. Crichton, I. R. Badell
Department of Surgery, Emory, Atlanta, GA
*Purpose: Donor-directed HLA antibodies are an important cause of renal allograft injury, but effective therapeutic options to prevent or eliminate donor-specific antibodies (DSA) do not…
2021 American Transplant Congress
Islet Isograft Transplantation Improves Insulin Sensitivity in a Murine Model of Type 2 Diabetes
S. Lim, M. Choi, M. Kim, Y. Wee, H. Kwon, C. Jung, Y. Kim, D. Han, S. Shin
Asan Medical Center, Seoul, Songpa, Korea, Republic of
*Purpose: Type 2 diabetes develops in the presence of chronic overnutrition and genetic susceptibility, and causes insulin resistance and relative insulin deficiency. We hypothesized that…