Am J Transplant, Volume 21, Suppl 3 Archives - Page 29 of 139 - ATC Abstracts

2021 American Transplant Congress
In Vitro Generated Regulatory B Cells Induce Cd4⁺Cd25⁺Foxp3⁺Tregs from Cd4⁺Cd25^–T Cells via TGF-β
G. Huai¹, K. Lee², K. Deng², Q. Fu¹, C. G. Rickert², S. Deng¹, C. LeGuern², J. F. Markmann²
¹Department of Organ Transplantation Center, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China, ²Center for Transplantation Sciences, Massachusetts General Hospital, Harvard Medical School, Boston, MA
*Purpose: Our team previous study showed that TLR-Bregs, stimulated through TLR pathway in vitro, harbored regulatory properties by suppressing CD4+ T cell proliferation and function…
2021 American Transplant Congress
Lacripep^TM-like Peptide N-104 Promotes Beta Cell Proliferation in Murine Pancreatic Islets
M. Ma, P. Chhabra, K. Fread, K. Dias Teixeira, G. Laurie, K. Brayman
University of Virginia Health System, Charlottesville, VA
*Purpose: To monitor time-dependent cellular changes, with emphasis on beta cell regeneration, in pancreatic islets following treatment with LacripepTM-like peptide N-104 by mass cytometry. Background:…
2021 American Transplant Congress
Novel Morphologic Biomarkers of Cardiac Allograft Remodeling are Associated with Multiple Peri- and Post-transplant Inflammatory Processes
C. Yuan¹, S. Arabyarmohammadi¹, H. Li¹, E. Peyster², P. Lal³, M. Feldman³, K. Margulies², A. Madabhushi¹
¹Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, ²Cardiovascular Research Institute, University of Pennsylvania, Philadelphia, PA, ³University of Pennsylvania, Philadelphia, PA
*Purpose: It has long been recognized that transplanted hearts develop a stiffened, restrictive physiology at an accelerated rate compared to native hearts. While this is…
2021 American Transplant Congress
Laminins Differentially Regulate Tolerogenic T Cell Migration and Homing to Lymph Nodes
L. Li¹, M. Shirkey¹, W. Piao¹, Y. Xiong¹, V. Saxena², T. Zhang¹, J. Iyyathurai², R. Lakhan¹, R. Abdi³, J. Bromberg¹
¹Surgery, UMB, Baltimore, MD, ²CVID, UMB, Baltimore, MD, ³Harvard University, Boston, MA
*Purpose: Laminin α5 (Lama5) and α4 (Lama4), which are produced by lymph node (LN) stromal cells, influence CD4 T cell migration and stimulation. We hypothesized…
2021 American Transplant Congress
Effects of IL-2 and/ or Anti-IL6R Therapy on Long-term Cardiac Allograft Survival in Non-Human Primates (NHPs)
C. L. Miller, K. J. Ahrens, J. M. O, P. M. Patel, J. A. Morrissette, D. Becerra, T. Costa, A. Dehnadi, I. M. Hanekamp, G. Benichou, J. C. Madsen
Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA
*Purpose: Cardiac allograft tolerance in NHPs has been achieved by our group using a mixed chimerism model with allogeneic bone marrow transplant after non-myeloablative conditioning…
2021 American Transplant Congress
Transgenic Overexpression of Human Ectonucleoside Triphosphate Diphosphohydrolase 1 (entpd1, Or Hcd39) in Pig to Primate Xenotransplantation Models
R. Matheson¹, K. Deng¹, K. M. Lee¹, Z. A. Habibabady¹, C. G. Rickert¹, K. J. Ahrens¹, J. M. O¹, D. Becerra¹, P. Patel¹, W. Westlin², M. Youd², N. Serifis¹, T. M. Coe¹, D. Cloonan¹, A. M. Azimzadeh¹, C. LeGuern¹, J. C. Madsen¹, S. C. Robson³, J. F. Markmann¹
¹Transplantation Surgery Research, Massachusetts General Hospital, Boston, MA, ²eGenesis, Cambridge, MA, ³Beth Israel Deaconess Medical Center, Boston, MA
*Purpose: Human CD39 (hCD39) is the gene of interest in xenotransplantation due to its reported capacity to prevent platelet aggregation by metabolizing extracellular ATP to…
2021 American Transplant Congress
Tubastatin-a Mediated Protection from Liver Injury is Preserved in a Lymphocyte Deficient Model
C. S. O'Brien¹, P. Hernandez¹, Z. Wang¹, G. Ge¹, A. Kozikowski², W. Hancock¹, M. H. Levine¹
¹University of Pennsylvania, Philadelphia, PA, ²University of Illinois at Chicago, Chicago, IL
*Purpose: Liver Ischemia reperfusion injury (IRI) and Acetaminophen (APAP) toxicity are important causes of acute liver failure in the United States, that lack effective therapy.…
2021 American Transplant Congress
General Public Attitude Toward Vascularized Composite Allografts (VCA) Donation?
M. S. S Gharibdousti¹, M. T Khasawneh¹, A. L Friedman²
¹System Science and Industrial Engineering, Binghamton University, Vestal, NY, ²LiveOnNY, New York City, NY
*Purpose: To analyze factors associated with affirmative authorization for VCA donation from public opinion.*Methods: KnowledgePanel is the largest online panel that relies on probability-based sampling…
2021 American Transplant Congress
Combined Donor Derived Cell Free DNA (AlloSure) and Peripheral Immune Cell Gene Expression (AlloMap) Testing for the Diagnosis of Rejection in Kidney Transplant Recipients with De Novo Donor Specific Antibodies
K. R. Degner, S. Parajuli, F. Aziz, N. Garg, D. Mandelbrot, M. Mohamed, K. Van Hyfte, S. R. Reese, N. A. Wilson, A. Djamali
University of Wisconsin, Madison, WI
*Purpose: Combined donor-derived cell-free DNA (dd-cfDNA, AlloSure) and peripheral immune cell gene expression (AlloMap) may increase the predictive value of de novo DSA (dnDSA) for…
2021 American Transplant Congress
Immunosuppression is Not Associated with High-risk Immunologic Parameters in Transplant Recipients with the Sars-cov2 Virus
S. Merl, R. Jones, B. Shonts, D. Rust, M. Sykes, J. Weiner
Medicine/Surgery, Columbia University Medical Center, New York, NY
*Purpose: The factors associated with severe COVID-19 disease in transplant patients are poorly understood. Despite concern that patients with weakened immune responses have increased risk…