Am J Transplant, Volume 21, Suppl 3 Archives - Page 29 of 139 - ATC Abstracts

2021 American Transplant Congress
Randomized Phase 3 Open-label Study of Maribavir vs Investigator-assigned Therapy for Refractory/resistant Cytomegalovirus Infection in Transplant Recipients: Subgroup Analyses of Efficacy by Organ
R. K. Avery¹, E. A. Blumberg², D. Florescu³, N. Kamar⁴, D. Kumar⁵, J. Wu⁶, A. Sundberg⁶
¹Johns Hopkins Hospital, Baltimore, MD, ²University of Pennsylvania, Philadelphia, PA, ³University of Nebraska School of Medicine, Omaha, NE, ⁴Hôpital de Rangueil, Toulouse, France, ⁵University Health Network, Toronto, ON, Canada, ⁶Shire Human Genetic Therapies, Inc., a Takeda company, Lexington, KY
*Purpose: Therapeutic options for refractory, with/without resistance (R/R), CMV infections are limited. We report organ type subgroup analyses from a large multi-center trial that studied…
2021 American Transplant Congress
Laminin Alpha 4 and Alpha5 Differentially Regulate Lymph Node Tolerogenic Structure
L. Li¹, M. Shirkey¹, W. Piao¹, Y. Xiong¹, V. Saxena¹, T. Zhang¹, J. Iyyathurai², R. Lakhan¹, R. Abdi³, J. Bromberg¹
¹Surgery, UMB, Baltimore, MD, ²CVID, UMB, Baltimore, MD, ³Harvard University, Boston, MD
*Purpose: Lymph node (LN) stromal laminins α4 (Lama4) and α5 (Lama5) are associated with tolerance and immunity, respectively. We hypothesized that stromal Lama4 and Lama5…
2021 American Transplant Congress
Novel Discovery of Super-antigen That Mobilize Regulatory Cd8 T Cells Inhibits Donor-specific Antibody and Protects Heart Allografts from Antibody-mediated Rejection
J. Y. Choi¹, H. Nakagawa², Z. Solhjou¹, K. Yatim¹, H. Zhang³, P. Patel³, M. Tawfeek Mohammed³, L. Riella⁴, H. Kim², H. Cantor², J. Azzi¹
¹Brigham and Women's Hospital/Harvard Medical School, Boston, MA, ²Dana Farber Cancer Institute/Harvard Medical School, Boston, MA, ³Brigham and Women's Hospital, Boston, MA, ⁴Massachusetts General Hospital/Harvard Medical School, Boston, MA
*Purpose: Antibody-mediated rejection (AMR) is a critical barrier to long-term allograft survival. We showed that Qa-1 (HLA-E in humans) restricted CD8+ T cells (CD8 Treg)…
2021 American Transplant Congress
The Role of Pre-transplant Rectal Screening for Azole-resistant Candida Species in Liver Transplant Candidates
K. K. Patel¹, M. M. Azar², A. Koff³, K. Belfield⁴, D. R. Peaper⁵, J. Topal², M. Malinis²
¹Yale School of Medicine, New Haven, CT, ²Section of Infectious Diseases, Yale School of Medicine, New Haven, CT, ³Section of Infectious Diseases, UC Davis, Sacramento, CA, ⁴Department of Pharmacy, Yale New Haven Hospital, New Haven, CT, ⁵Department of Laboratory Medicine, Yale School of Medicine, New Haven, CT
*Purpose: Azole-resistant Candida (ARC) infections have become increasingly common among solid organ transplant recipients. Pre-transplant screening for ARC allows for targeted antifungal prophylaxis, which may…
2021 American Transplant Congress
Multistep Algorithm to Achieve Weight Loss Goal in Advanced Stage Obesity Kidney Transplant Candidates: A Single Center Preliminary Report
A. Shah, J. Galpern, L. Castaldo, P. Touhy, M. Thomas, A. Aaron, M. Fruscione, L. Dageforde, N. Elias
Transplant Surgery, Massachusetts General Hospital, Boston, MA
*Purpose: Obesity causes and complicates glomerulonephritis and chronic kidney disease (CKD) leading to end stage renal disease (ESRD). Kidney Transplantation (KT) improves ESRD patients’ survival…
2021 American Transplant Congress
Pig Orthotopic Heart Transplantation (ohtx) in Baboons: Is an Acute Pulmonary Inflammatory Response the Key Problem?
A. Jagdale¹, D. Cleveland², M. Bikhet¹, J. Foote³, G. Walcott⁴, H. Iwase¹, T. Yamamoto¹, H. Hara¹, C. Hansens-Estruch¹, D. Ayares⁵, S. Litovsky⁶, L. Rhodes², W. Carlo⁷, J. Crawford², R. Dabal², S. Borasino², D. Cooper¹
¹Surgery, University of Alabama at Birmingham, Birmingham, AL, ²Cardiothoracic Surgery, Children's of Alabama, Birmingham, AL, ³Medicine and Cardiovascular Diseases, University of Alabama at Birmingham, Birmingham, AL, ⁴Medicine, University of Alabama at Birmingham, Birmingham, AL, ⁵Surgery, Revivicor, Blacksburg, VA, ⁶Pathology, University of Alabama at Birmingham, Birmingham, AL, ⁷Division of Pediatric Cardiology, Department of Pediatrics, University of Alabama at Birmingham, Children's of Alabama, Birmingham, AL
*Purpose: To investigate the mechanism of early cardio-pulmonary dysfunction after genetically engineered pig OHTx in baboons.*Methods: OHTx from pigs expressing different genetic modifications, α‐galactosyltransferase knockout…
2021 American Transplant Congress
Outcomes of Hepatitis C Nucleic Acid Testing Positive Donors in Aviremic Recipients With Delayed Direct-Acting Antiviral Initiation
M. Hudson, A. Webb, A. Logan, A. Silverman, A. Brueckner
Pharmacy, Tampa General Hospital, Tampa, FL
*Purpose: The purpose of this study was to assess the clinical impact of utilizing hepatitis C virus (HCV) nucleic acid testing (NAT)+ donors in HCV…
2021 American Transplant Congress
Robotic Donor Nephrectomy: Advantages Offered by a Minimally Invasive Approach to Kidney Transplantation
A. Popovic¹, R. Shahbazov¹, A. Hoste¹, S. Loerzel¹, B. Gallay², J. Leggat², O. Pankewycz¹, R. Saidi¹, R. H. Dvorai³, M. J. Hanlon¹, S. Narsipur², M. R. Laftavi¹
¹Surgery, SUNY Upstate Medical University, Syracuse, NY, ²Medicine, SUNY Upstate Medical University, Syracuse, NY, ³Pathology, SUNY Upstate Medical University, Syracuse, NY
*Purpose: Our aim was to further explore the difference in results between laparoscopic and robotic assisted techniques of living donor nephrectomies*Methods: This is a retrospective…
2021 American Transplant Congress
Athena – Effect of Primary Immunosuppression on Development of De Novo Donor Specific Antibodies within First Year After Kidney Transplantation
W. Arns¹, A. Philippe¹, V. Ditt¹, I. A. Hauser¹, F. Thaiss¹, C. Sommerer¹, B. Suwelack¹, A. Finkel², C. Schiedel², D. Dragun¹, B. Nashan¹
¹ATHENA, Study Group, Germany, ²Novartis Pharma GmbH, Nuremberg, Germany
*Purpose: The ATHENA trial [NCT01843348] investigated safety and efficacy of everolimus combined with cyclosporine A [EVR/CsA] or tacrolimus [EVR/TAC] vs. tacrolimus plus mycophenolic acid [MPA/TAC]…
2021 American Transplant Congress
Should We Curtail the Importance of Non-modifiable Risk Factors in Dcd Liver Risk Stratification?
R. Meier¹, Y. Kelly², S. Yamaguchi², H. Braun², T. Lunow-Luke², D. Adelmann², C. Niemann², D. Maluf¹, Z. Dietch², P. Stock², S. Kang², S. Feng², A. Posselt², J. Gardner², C. Freise², R. Hirose², C. Freise², N. Ascher², J. Roberts², G. Roll²
¹University of Maryland, Baltimore, Baltimore, MD, ²UCSF, San Francisco, CA
*Purpose: Scoring systems have been proposed to select donation after circulatory death (DCD) donors and recipients for liver transplantation (LT). We hypothesized that the generalizability…