2021 American Transplant Congress
TIGIT Identifies Polyfunctional Donor-Specific CD4+ T Cells Lost After Kidney Transplantation
Nephrology and Transplantation, Erasmus MC, Rotterdam, Netherlands
*Purpose: Development of T-cell hyporesponsiveness to donor antigen may explain the substantial decrease in the risk for acute rejection in the years following kidney transplantation.…2021 American Transplant Congress
Conversion to Belatacept Based Immunosuppression Regimen in Kidney Transplant Patients: Lessons Learned
*Purpose: The costimulatory inhibitor, belatacept (Bela) has been shown to be an effective alternative in several clinical situations including calcineurin toxicity, de novo alloantibody formation…2021 American Transplant Congress
Degree of T Cell Infiltration Predicts Treatment Response in Pediatric Liver Late Acute Cellular Rejection
Cincinnati Children's Hospital Medical Center, Cincinnati, OH
*Purpose: Late acute cellular rejection (ACR) occurs >6mo post-liver transplant and is associated with chronic rejection and allograft loss. Currently, no diagnostic features predict ACR…2021 American Transplant Congress
A Comparison of Pediatric Intestine Transplant Between the Current Era (2015-2019) and the Peak Period (2002-2006)
1Seattle Children's Hospital, Seattle, WA, 2SRTR, Minneapolis, MN
*Purpose: Demand for intestine transplants in children grew from its clinical inception in the late 1980s to a peak in 2007 of 111 small bowel-containing…2021 American Transplant Congress
T-Cell Exhaustion in EBV DNAemic Solid Organ Transplant Recipients
Multi-Organ Transplant Program, University Health Network, Toronto, ON, Canada
*Purpose: In transplant recipients, disease severity after infection with Epstein-Barr virus (EBV) may range from asymptomatic DNAemia to PTLD. Host factors likely play a key…2021 American Transplant Congress
Racial and Sexual Disparities in Solid Organ Transplant Outcomes Since Implementation of the Affordable Care Act Insurance Expansion Across Some States
*Purpose: Achieving solid organ transplantation traditionally requires access to health insurance. As such, women and people of color have faced barriers to obtaining solid-organ transplants.…2021 American Transplant Congress
Evolving Trends in Risk Profiles and Outcomes in Older Adults Undergoing Kidney Re-Transplantation
1McGill University, Montreal, QC, Canada, 2Johns Hopkins University, Baltimore, MD
*Purpose: The half-life of a kidney transplant (KT) is 8-12 years, and a significant proportion of patients end up with graft loss at age ≥65…2021 American Transplant Congress
AT-1501, a Novel and Clinically Applicable CD40L Specific Monoclonal Antibody, Promotes Islet Allograft Survival in Nonhuman Primates
*Purpose: Immune intervention with a CD40L specific monoclonal antibody (mAb, Hu5c8, Biogen) has previously been shown to safely and effectively prevent islet allograft (IA) rejection…2021 American Transplant Congress
Outcomes of Short-Duration Anti-Viral Prophylaxis for Hepatitis C Positive Donor Kidney Transplants
Virginia Commonwealth University Health System, Richmond, VA
*Purpose: Trials describing 4-12 week courses of direct-acting anti-viral drugs (DAAs) to treat hepatitis C virus (HCV) transmission from infected donors to uninfected kidney transplant…2021 American Transplant Congress
Pilot Study for the Use of Shortened Preemptive Therapy with Glecaprevir/pibrentasvir (g/p) and Ezetimibe in Hepatitis C Seronegative Solid Organ Transplant Recipients (Kidney and Heart) of Hepatitis C Viremic Donors
*Purpose: This prospective study aims to assess the efficacy of preemptive therapy with eight days of a combination of direct-acting antivirals (DAAs) (Mavyret) (Pibrentasvir /Glecaprevir)…
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