Am J Transplant, Volume 21, Suppl 3 Archives - Page 29 of 139 - ATC Abstracts

2021 American Transplant Congress
Accelerated Bronchiolitis Obliterans After Lung Transplant Promoted by an ATG16L1 Mutation is Coupled to Mitochondrial Damage and Metabolic Alterations in Monocyte-derived Antigen Presenting Cells
M. Cano¹, D. Zhou¹, D. Kreisel¹, C. Chen², K. Pugh¹, D. Byers¹, R. Hachem¹, A. Gelman¹
¹Washington University, Saint Louis, MO, ²UT Southwestern Medical Center, Dallas, TX
*Purpose: Bronchiolitis obliterans (BOS) remains a major cause of death for lung transplant recipients, and the mechanisms that drive BOS remain poorly understood. It is…
2021 American Transplant Congress
Characterization of Retransplantation Following Graft Failure Due to Bkvn
K. Nguyen¹, H. Curtis², J. Panichella², H. Resweber³, A. Di Carlo², S. Karhadkar¹
¹Surgery, Temple University School of Medicine, Philadelphia, PA, ²Surgery, Temple University School of Medicine, Philadephia, PA, ³Surgery, Temple University School of Medicine, Gladwyne, PA
*Purpose: Immunosuppression following kidney transplantation allows for the reactivation of BK polyomavirus (BKV)- frequently implicated in graft dysfunction and failure. Although BKV Nephropathy (BKVN) was…
2021 American Transplant Congress
Age and Racial Disparities in Access to Re-kidney Transplantation
S. S. Patole¹, J. Ahn¹, S. Sandal², D. Segev¹, M. McAdams Demarco³
¹Department of Transplantation Surgery, Johns Hopkins School of Medicine, Baltimore, MD, ²McGill University, Montreal, QC, Canada, ³Department of Epidemiology, Johns Hopkins School of Medicine, Baltimore, MD
*Purpose: Graft failure is likely increasing among kidney transplant (KT) recipients due to improvements in patient survival. While the benefits of re-KT have been well…
2021 American Transplant Congress
Comprehensive Utilization of HCV Viremic and Non-Viremic Donor Livers and Kidneys into HCV-negative Patients
M. E. de Vera, J. Woloszyn, J. Sterris, M. Robinson, R. Evans, S. Blais, B. Elhazin, C. Amador, c. Berk, M. Volk, R. Villicana
Transplant Institute, Loma Linda University Health, San Bernardino, CA
*Purpose: We report our experience on virologic and graft outcomes of HCV-negative patients transplanted with HCV NAT+ (viremic) and HCV Ab+/NAT- (non-viremic) livers and kidneys…
2021 American Transplant Congress
Adenovirus-Specific T Cells for Steering of Immunosuppression After Pediatric Kidney Transplantation in the Randomized Controlled Ivist Trial
T. Ahlenstiel-Grunow¹, X. Liu², R. Schild³, J. Oh³, C. Taylan⁴, L. T. Weber⁴, H. Staude⁵, M. Verboom⁶, C. Schröder⁷, R. Sabau⁷, A. Großhennig², L. Pape¹
¹Pediatrics II, University Hospital of Essen, Essen, Germany, ²Institute of Biostatistics, Hannover Medical School, Hannover, Germany, ³Pediatric Nephrology, University Hospital Hamburg-Eppendorf, Hamburg, Germany, ⁴Pediatric Nephrology, University of Colgne, Köln, Germany, ⁵Pediatric Nephrology, University Hospital of Rostock, Rostock, Germany, ⁶Institute of Transfusion Medicine and Transplant Engineering, Hannover Medical School, Hannover, Germany, ⁷Institute for Clinical Pharmacology, Hannover Medical School, Hannover, Germany
*Purpose: Pharmacokinetic monitoring alone is insufficient to estimate the intensity of immunosuppression after pediatric kidney transplantation (Tx). Levels of virus-specific T cells (Tvis) have been…
2021 American Transplant Congress
CD47-Mediated Gli1/Notch1 Signaling is a Key Regulator of Mesenchymal Stem Cell Immunomodulation in Liver Inflammatory Injury
D. Xu, M. Sheng, Y. Lin, Y. Tian, Y. Zhan, C. Li, A. J. Coito, R. W. Busuttil, D. G. Farmer, J. W. Kupiec-Weglinski, B. Ke
Surgery, Dumont - UCLA Transplant Center, Los Angeles, CA
*Purpose: The CD47-signal regulatory protein alpha (SIRPα) signaling pathway plays important roles in immune homeostasis and tissue inflammatory response. Gli1, the downstream effector of the…
2021 American Transplant Congress
Beyond Microarrays: Insights from Ncounter Transcript Analysis of Routine Archival Kidney Allograft Biopsies
I. Rosales, K. Tomaszewski, A. Milagros, T. Kawai, R. Smith, R. Colvin
Massachusetts General Hospital, Boston, MA
*Purpose: Microarray mRNA analysis of renal allograft biopsies has discovered important insights, but has limitations as a practical clinical test. Here we evaluate a new…
2021 American Transplant Congress
Effect of Early Biopsy-Proven Rejection on Liver Transplant Outcomes
D. D. Aufhauser, N. Marka, L. Stalter, G. Levenson, D. Al-Adra, D. P. Foley
Surgery, University of Wisconsin, Madison, WI
*Purpose: Existing literature offers conflicting conclusions about whether early acute cellular rejection influences long-term outcomes in liver transplantation.*Methods: We retrospectively collected donor and recipient data…
2021 American Transplant Congress
Eosinophils Attenuate Hepatic Ischemia Reperfusion Injury in Mice Through St2-Dependent Il-13 Production
Y. Yang, Y. Wang, M. Wang, J. Jeong, L. Xu, Y. Wen, C. Emontzpohl, W. Dar, C. Ju
Department of Anesthesiology, McGovern Medical School University of Texas Health Science Center at Houston, Houston, TX
*Purpose: The purpose is to investigate the functional role of eosinophils during hepatic ischemia and reperfusion injury (IRI).*Methods: Mice with antibody-induced eosinophil depletion and two…
2021 American Transplant Congress
Pre- Kidney Donation Pregnancy Complications and Long-Term Outcomes
E. Helgeson¹, E. F. Palzer¹, D. Vock¹, A. Matas²
¹University of Minnesota School of Public Health, Minneapolis, MN, ²University of Minnesota Medical School, Minneapolis, MN
*Purpose: In general, hypertension (HTN), proteinuria, or diabetes (DM) are exclusion criteria for living kidney donation in young candidates. Exceptions are made for conditions only…