ATC Abstracts

American Transplant Congress abstracts

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  • 2021 American Transplant Congress

    Successful Induction of Hematopoietic Chimerism by Dual Inhibition of Mcl-1 and Bcl-2 Without Myeloablative Treatments in Nonhuman Primates

    T. Hirose, D. Ma, G. Lassiter, T. Kawai

    Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA

    *Purpose: Induction of hematopoietic chimerism by donor bone marrow transplantation (BMT) is essential for achievement of allograft tolerance in clinical HLA mismatched kidney transplantation, while…
  • 2021 American Transplant Congress

    Clinical Outcomes Associated with Induction Therapy Regimens for Kidney Transplantation in Children: A NAPRTCS and PHIS Collaborative Report

    H. Pizzo1, D. Levy Erez2, N. M. Rodig3, T. Richardson4, M. Somers3

    1Pediatric Nephrology, Cedars-Sinai Medical Center, Los Angeles, CA, 2Nephrology Institute, Schneider Children's Medical Center, Tel Aviv, Israel, 3Nephrology, Boston Children's Hospital, Boston, MA, 4Children's Hospital Association, Lenexa, KS

    *Purpose: Choice of induction agent at the time of pediatric kidney transplant (KTx) is often based upon patient characteristics and center practice. There are limited…
  • 2021 American Transplant Congress

    Center Use of Technical Variant Grafts Impacts Pediatric Liver Transplant Waitlist and Recipient Outcomes in the United States

    G. Mazariegos1, E. R. Perito2, J. Squires1, K. Soltys1, A. Griesemer3, S. A. Taylor4, E. Pahl5

    1Childrens Hosp of Pittsburgh, Pittsburgh, PA, 2UCSF, San Francisco, CA, 3Columbia University Irving Medical Center, New York, NY, 4Lurie Children's Hospital of Chicago, Chicago, IL, 5Omnilife, Lexington, KY

    *Purpose: Assessing composite outcome measures are critical when evaluating graft type selection in pediatric liver transplantation (LT).*Methods: OPTN data on children listed for first-time LT…
  • 2021 American Transplant Congress

    Single-Cell RNA-seq Identifies Intra-Graft Population Heterogeneity in Acute Heart Allograft Rejection in the Mouse

    C. Wu1, Y. Tang1, X. Shi1, X. He1, X. Li2

    1The First Affiliated Hospital,Sun Yat-sen University, Guangzhou, China, 2Immunobiology & Transplant Sciences Houston Methodist Hospital, Houston, TX

    *Purpose: Transplant rejection remains a major barrier to graft survival and involves a diversity of cell types. But the heterogeneity in a given cell type…
  • 2021 American Transplant Congress

    De Novo Hepatitis B Infection Following Liver Transplant with Hepatitis B Core Antibody Positive Graft

    L. J. Myhre1, K. D. Watt2, B. A. Aqel3

    1Pharmacy, Mayo Clinic, Rochester, MN, 2Gastroenterology/Hepatology, Mayo Clinic, Rochester, MN, 3Gastroenterology/Hepatology, Mayo Clinic, Phoenix, AZ

    *Purpose: The risk of de novo HBV infection in liver transplant recipients of Hepatitis B core antibody (HBcAb) positive donor organs is tempered by availability…
  • 2021 American Transplant Congress

    Black Patients with Cirrhosis Have Longer Length of Stay and Higher Mortality When Hospitalized

    A. Thomas1, D. Simpson2, D. P. Ladner2, R. Berkowitz2

    1ACS Clinical Scholar, Chicago, IL, 2Transplant Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL

    *Purpose: Black patients with cirrhosis have been shown to have higher liver-related mortality compared to White patients. However, little knowledge exists about racial differences related…
  • 2021 American Transplant Congress

    Understanding Transplant Decision Making Concerns for African, Caribbean and Black Canadian Patients with End-Stage Kidney Disease

    N. Singh1, A. Wasim1, W. Hajjar1, K. Mohan1, N. El-Dassouki1, H. Habbal1, L. Angarso1, A. Dychiao1, S. Macanovic1, A. D. Waterman2, I. Mucsi1

    1University Health Network, Toronto, ON, Canada, 2David Geffen School of Medicine, UCLA, Los Angeles, CA

    *Purpose: Compared to White Canadians, African, Caribbean and Black (ACB) Canadians with end stage kidney disease (ESKD) are less likely to receive a living donor…
  • 2021 American Transplant Congress

    Belatacept and Carfilzomib-based Treatment of Active Antibody-mediated Rejection in a Sensitized Nonhuman Primate Model

    J. Kwun1, R. Schmitz1, M. Manook1, Z. Fitch1, D. Olaso1, A. Choi1, J. Yoon1, Y. Bae1, J. Lambris2, S. Knechtle1

    1Surgery, Duke University, Durham, NC, 2Pathology & Laboratory Medicine, University of Pennsylvania, Philadelphia, PA

    *Purpose: One third of sensitized, HLA-incompatible transplant recipients experience antibody-mediated rejection (AMR) with limited effective treatment options. We tested a novel treatment strategy for AMR…
  • 2021 American Transplant Congress

    Are Tacrolimus Concentrations Reduced with Direct-acting Antiviral Administration in Transplant Recipients?

    K. Huang, K. Farrow, M. Christian

    Pharmacy, Penn State Health Hershey Medical Center, Hershey, PA

    *Purpose: To evaluate the effects of direct-acting antivirals (DAAs) on tacrolimus trough concentrations and clinical outcome and to assess the need for a priori dose…
  • 2021 American Transplant Congress

    Drones and Airplanes: Modeling the Potentially Deleterious Effects of Transportation on Shipped Organs

    Y. S. Lee, J. S. Bromberg, J. R. Scalea

    Surgery, University of Maryland, Baltimore, MD

    *Purpose: During the first shipments of human organs by drone, we identified significant differences in pressure and vibration that may adversely affect shipped organs. Liver…
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