Am J Transplant, Volume 21, Suppl 3 Archives - Page 114 of 139 - ATC Abstracts

2021 American Transplant Congress
Living Donor Kidney Transplantation Racial Disparities Persist Independent of Social Vulnerability
A. C. Killian¹, M. C. McLeod¹, B. Shelton¹, R. D. Reed¹, P. MacLennan¹, H. Qu¹, B. J. Orandi¹, V. Kumar¹, D. Sawinski², R. M. Cannon¹, D. J. Anderson¹, M. J. Hanaway¹, J. E. Locke¹
¹University of Alabama at Birmingham Hospital, Birmingham, AL, ²Hospital of the University of Pennsylvania, Philadelphia, PA
*Purpose: Living donor kidney transplantation (LDKT) confers a significant survival benefit over deceased donor transplantation. Racial disparities in access to LDKT are well recognized, yet…
2021 American Transplant Congress
Addressing a Need in Transplant Clinical Care: Creation of the Organ Transplant Caregiver Toolkit
H. Bruschwein¹, G. Chen², A. Ortega³, W. Balliet⁴, T. Coco⁵, C. Thomas⁶, B. Hansen⁵, D. Richardson⁷, K. Canavan⁸, C. Burch⁹, A. Yaldo¹⁰, M. Jesse¹¹
¹University of Virginia School of Medicine, Charlottesville, VA, ²Memorial Hermann Transplant Center, Houston, TX, ³Memorial Transplant Institute, Miami, FL, ⁴Medical University of South Carolina, Charleston, SC, ⁵Mayo Clinic, Pheonix, AZ, ⁶Banner Transplant Institute, Pheonix, AZ, ⁷Caregiver, Minburn, IA, ⁸National Kidney Foundation, New York, NY, ⁹Stanford Children's Hospital, Palo Alto, CA, ¹⁰University of Michigan, Ann Arbor, MI, ¹¹Henry Ford Transplant Institute, Detroit, MI
*Purpose: Lay or informal caregivers are a critical component of pre- and post-operative care in adult organ transplantation and living donation. Caregiving in organ transplantation…
2021 American Transplant Congress
Allograft Function and Baseline Donor Derived Cell Free DNA in Kidney Transplant Recipients: One Size Doesn’t Fit All
K. K. Sureshkumar, A. Grazier, B. Chopra
Allegheny General Hospital, Allegheny Health Network, Pittsburgh, PA
*Purpose: Donor derived cell free DNA (dd-cfDNA) is increasingly used to predict acute rejection in kidney allografts . Cell free DNA fragments are constantly released…
2021 American Transplant Congress
Video Virtual Transplant Evaluation and Listing
V. Casingal¹, B. Thrasher², J. Brown², C. Fotiadis²
¹Department of Surgery, Atrium Health, Charlotte, NC, ²Department of Transplant, Atrium Health, Charlotte, NC
*Purpose: Due to the COVID-19 pandemic, many hospitals suspended in person evaluations of kidney transplants during the March-April time period of 2020. State and local…
2021 American Transplant Congress
Value of a Personal Systems Approach in Improving Medication Adherence in Adult Kidney Transplant Patients: A Cost-effectiveness Analysis of the MAGIC Randomized Clinical Trial
M. R. Wakefield¹, M. Whittington², C. Ashbaugh³, L. M. Remy⁴, D. Aholt⁴, C. Miller⁴, D. Hathaway⁵, D. Clark⁵, K. Goggin⁵, R. J. Ellis⁶, C. L. Russell⁴
¹Surgery/Urology, University of Missouri School of Medicine, Columbia, MO, ²University of Kansas Medical Center, Kansas City, KS, ³University of Missouri Health Care, Columbia, MO, ⁴University of Missouri-Kansas City, Kansas City, MO, ⁵Children's Mercy Kansas City, Kansas City, MO, ⁶Indiana University School of Nursing, Indianapolis, IN
*Purpose: The objective of this evaluation was to estimate the cost of implementation and the cost-effectiveness of a person-level intervention called SystemCHANGETM .*Methods: To estimate…
2021 American Transplant Congress
Re-Transplantation of Mouse Kidney Grafts to Study Local Immune Responses
D. Zhao, M. Oberbarnscheidt, F. Lakkis, K. Khodor
Starzl Transplantation Institution, Pittsburgh, PA
*Purpose: Mouse kidney transplantation has been widely used to study the immune response to allogeneic grafts. This response includes a circulating systemic compartment and a…
2021 American Transplant Congress
A Novel Mouse Model of Cardiac Allograft Vasculopathy
H. Tsuda¹, E. Reed², W. Baldwin¹, R. Fairchild¹
¹Inflammation and Immunity, Cleveland Clinic, Cleveland, OH, ²Pathology and Laboratory Medicine, University of California, Los Angeles, CA
*Purpose: Cardiac allograft vasculopathy (CAV) is a major long-term complication of heart transplantation and the presence of donor specific antibodies (DSA) is associated with an…
2021 American Transplant Congress
Src Kinase Inhibitor Pp1 Blunts Tgf-β1 Dependent Endothelial‐to‐Mesenchymal Transition to Alleviate Allograft Kidney Fibrosis Through Orchestrating β-catenin Signaling
Z. Gui, Z. Wang, Z. Han, J. Tao, X. Ju, R. Tan, M. Gu
Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
*Purpose: Allograft fibrosis is an important contributor to graft loss in chronic renal allograft injury. Endothelial‐to‐mesenchymal transition (EndMT), dysfunction of endothelial cells, played a vital…
2021 American Transplant Congress
Recipient Neutrophils Producing Myeloperoxidase Provoke Nk Cell and Monocyte/macrophage Activation During Acute Antibody-mediated Rejection of Kidney Allografts
D. Ueda, S. Miyairi, K. Keslar, W. M. Baldwin, R. L. Fairchild
Lerner Research Institute, Cleveland Clinic, Cleveland, OH
*Purpose: Dysregulated donor-specific antibody (DSA) responses are induced in B6.CCR5-/- mice transplanted with complete MHC mismatched A/J kidney allografts and mediate acute graft rejection. Acute…
2021 American Transplant Congress
CRISPR Screens to Map CTLA-4 Regulatory Networks in Primary Human T Cells
O. Shaked¹, J. Freimer¹, J. Pritchard², A. Marson¹
¹UCSF, San Francisco, CA, ²Stanford University, Stanford, CA
*Purpose: For most cell types, the pathways that regulate the levels of critical disease-relevant genes are not known. Recent advances in gene editing have enabled…