ATC Abstracts

American Transplant Congress abstracts

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  • 2021 American Transplant Congress

    Classification of Distinct Patterns of Ischemic Cholangiopathy Following DCD Liver Transplantation: Distinct Clinical Courses and Long-Term Outcomes from a Multicenter Cohort

    K. P. Croome1, A. K. Mathur2, B. Aqel2, L. Yang1, J. K. Heimbach3, T. Taner3, C. B. Rosen3, R. Paz-Fumagalli1, C. Taner1

    1Mayo Clinic Jacksonville, Jacksonville, FL, 2Mayo Clinic Arizona, Scottsdale, AZ, 3Mayo Clinic Rochester, Rochester, MN

    *Purpose: As the number of donation after circulatory death (DCD) liver transplants (LTs) performed in the United States continues to increase annually, there has been…
  • 2021 American Transplant Congress

    The Impact of De Novo Dose-Adjustment Strategies with Tacrolimus XR (LCP-Tac) in Kidney Transplant Recipients

    T. Carcella, F. Bartlett, N. Patel, V. Rohan, D. Taber

    Medical University of South Carolina, Charleston, SC

    *Purpose: LCP-Tac is a once daily formulation of tacrolimus indicated for the prophylaxis of rejection in de novo kidney transplant recipients. It provides less variable…
  • 2021 American Transplant Congress

    Sensitized Lung Candidates Experience Reduced Access to Donor Organs

    K. Lindblad1, R. Goff2, D. Stewart2

    1UNOS, Richmond, VA, 2UNOS, Richmnd, VA

    *Purpose: Most studies of sensitization in transplant candidates have focused on kidney candidates, and unacceptable antigens (UAs) for non-kidney candidates are believed to be underreported.…
  • 2021 American Transplant Congress

    Acoustofluidic Device to Remove Donor Specific Antibody in a Sensitized Animal Model

    J. Kwun1, E. David2, Y. Gu3, Z. Ma3, M. Kuchibhatla4, G. Arepally5, T. J. Huang3, E. T. Chambers2

    1Surgery, Duke University, Durham, NC, 2Pediatrics, Duke University, Durham, NC, 3Biomedical Engineering, Duke University, Durham, NC, 4Biostatistics and Bioinformatics, Duke University, Durham, NC, 5Internal Medicine, Duke University, Durham, NC

    *Purpose: Current therapies for antibody-mediated rejection are neither donor-specific nor are they tailored toward children, resulting in premature allograft loss and increased mortality. Apheresis involves…
  • 2021 American Transplant Congress

    Cmv Specific Cellmediated Immune Reconstitution During Letermovir Prophylaxis in High Risk Hematopoietic Cell Transplant Recipients

    M. Abidi1, J. Gutman2, A. Weinberg2

    1University of Colorado Denver/Anschutz Medical Campus, Aurora, CO, 2University of Colorado Denver, Denver, CO

    *Purpose: Patients who are cytomegalovirus (CMV) seropositive (R+) prior to hematopoietic cell transplant (HCT), have a 30% incidence of clinically significant CMV reactivation in the…
  • 2021 American Transplant Congress

    Comorbidity Burden is Associated with Increased Waitlist Mortality Among NASH Patients

    J. R. Montgomery1, M. J. Englesbe1, C. Connelly2

    1Michigan Medicine, Ann Arbor, MI, 2General Surgery, Oregon Health & Science University, Portland, OR

    *Purpose: Nonalcoholic steatotic hepatitis (NASH) is an increasing and common indication for liver transplantation. The association between increased comorbidity burden and risk of death on…
  • 2021 American Transplant Congress

    Contribution of T-bet Expressing CD27+ CD21- Activated Memory B Cells Poised for Plasma Cell Differentiation to Antibody-mediated Rejection of Kidney Transplants

    K. Louis1, E. Bailly1, C. Macedo1, B. Ramaswami1, X. Gu1, G. Chalasani1, A. Zeevi1, P. Randhawa1, H. Singh2, C. Lefaucheur3, D. Metes1

    1Surgery, University of Pittsburgh, Pittsburgh, PA, 2Center for Systems immunology, Department of Immunology, University of Pittsburgh, Pittsburgh, PA, 3Human Immunology and Immunopathology, INSERM U976, Paris, France

    *Purpose: Alloimmunity triggered by donor-specific antibodies (DSAs) and ensuing development of antibody-mediated rejection (ABMR) are detrimental to organ transplants. Yet, the cellular states underlying B…
  • 2021 American Transplant Congress

    Duration and Magnitude of BK Viremia Do Not Predict Outcome in Patients After Kidney Transplantation

    E. A. Farkash1, J. T. Rajagopal2, M. Vincent2, M. D. Doshi3

    1Dept of Pathology, Michigan Medicine, Ann Arbor, MI, 2University of Michigan, Ann Arbor, MI, 3Dept of Nephrology, Michigan Medicine, Ann Arbor, MI

    *Purpose: BK viremia was a major cause of kidney transplant failure in the early 2000’s and remains a risk factor for subsequent rejection. The standard…
  • 2021 American Transplant Congress

    Geospatial Analysis of Organ Procurement Organizations and Its Impact on Organ Donation Rates

    D. Chyou1, K. Ross-Driscoll2, R. Lynch2, D. S. Goldberg1

    1University of Miami, Miami, FL, 2Emory University School of Medicine, Atlanta, GA

    *Purpose: For the majority of organ procurement organizations (OPOs), OPO staff travel to donor hospitals to obtain consent and manage donors, while OPO headquarters (HQ)…
  • 2021 American Transplant Congress

    Immunologic Endotypes of Ischemia-reperfusion Injury in Human Liver Transplantation

    R. A. Sosa, A. Q. Terry, F. M. Kaldas, B. V. Naini, T. Ito, R. W. Busuttil, D. W. Gjertson, J. W. Kupiec-Weglinski, E. F. Reed

    UCLA, Los Angeles, CA

    *Purpose: Ischemia-reperfusion injury (IRI) is a major risk factor for allograft rejection in orthotopic liver transplantation (OLT), involving complex interactions between innate and adaptive immune…
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