Am J Transplant, Volume 21, Suppl 3 Archives - Page 107 of 139 - ATC Abstracts

2021 American Transplant Congress
The Role of Donor-derived Cell-free DNA to Detect Subclinical Acute Rejection in Kidney Allograft
S. Park¹, K. Guo², R. Heilman³, E. Poggio⁴, D. Taber⁵, C. Marsh⁶, S. Kurian⁷, S. Kleiboeker⁸, J. Weems⁹, J. Holman¹⁰, L. Zhao², R. Sinha⁸, S. Brietigam², C. Rebello², M. Abecassis¹¹, J. Friedewald¹
¹Transplant nephrology, Northwestern University, Chicago, IL, ²Feinberg School of Medicine, Northwestern University, Chicago, IL, ³Transplant nephrology, Mayo Clinic College of Medicine and Science, Phoenix, AZ, ⁴Department of Nephrology and Hypertension, Cleveland Clinic, Cleveland, OH, ⁵Division of Transplant Surgery, Medical University of South Carolina, Charleston, SC, ⁶Department of Medicine and Surgery, Scripps Clinic and Green Hospital, La Jolla, CA, ⁷Scripps Health, La Jolla, CA, ⁸Eurofins US Clinical Diagnostics, Lee's Summit, MO, ⁹Eurofins US Clinical Diagnostics, Lee’s Summit, MO, ¹⁰Transplant Genomics, Inc, Mansfield, MA, ¹¹University of Arizona College of Medicine, Northwestern University, Tucson, AZ
*Purpose: We hypothesized that donor-derived cell-free DNA (dd-cfDNA) could detect subclinical acute rejection (subAR).*Methods: 429 blood samples paired with surveillance kidney biopsies from 208 patients…
2021 American Transplant Congress
Inflammation in Scarred Cortex (i-IFTA) is Significantly Associated with T Cell-mediated Rejection (TCMR), but Not Antibody-mediated Rejection (ABMR), in Renal Allograft Biopsies (Bx)
H. Zhang
Transplant Immunology Laboratory, Cedars-Sinai Medical Center, Los Angeles, CA
*Purpose: I-IFTA in renal allograft Bx has been found to be associated with decreased death-censored graft survival. Moderate to severe i-IFTA (2 or 3) is…
2021 American Transplant Congress
Effect of HLA Class II Polymorphism on Predicted Cellular Immunity Against SARS-CoV-2 at the Individual Level and Within Twenty Five Race/ethnic Groups
H. C. Copley¹, L. Gragert², A. R. Leach³, V. Kosmoliaptsis¹
¹Department of Surgery, University of Cambridge, Cambridge, United Kingdom, ²Department of Pathology, Tulane University School of Medicine, New Orleans, LA, ³European Bioinformatics Institute (EMBL-EBI), Hinxton, United Kingdom
*Purpose: Development of adaptive immunity after COVID-19 and after vaccination against SARS-CoV-2 is predicated on recognition of viral peptides, presented on HLA class II molecules,…
2021 American Transplant Congress
TOLS are Novel Regulatory TLOs with A B Cell Signature
I. Rosales¹, Q. Yuan¹, C. Yang¹, P. Russell¹, J. Madsen¹, A. Alessandrini¹, R. Colvin¹, -. AA and RC²
¹Massachusetts General Hospital, Boston, MA, ²Co-Senior Authors, Boston, MA
*Purpose: Our previous studies suggest that a DBA/2 kidney graft is accepted by a MHC-fully mis-matched C57/BL6 recipient. Accepted renal allografts exhibited lymphoid like structures…
2021 American Transplant Congress
Immunosuppression and Cancer Risk in Kidney Transplant Recipients: A Retrospective Cohort Study
R. Sapir-Pichhadze¹, C. Laprise¹, X. Zhang¹, M. Abrahamowicz¹, M. Beauchamp², A. Della Vecchia¹, L. Azoulay¹, E. Franco¹, B. Nicolau¹
¹McGill University, Montreal, QC, Canada, ²McGill University Health Centre, Montreal, QC, Canada
*Purpose: Kidney transplant recipients (KTR) have an elevated risk of cancer. We sought to estimate to what extent does the immunosuppression regimen increase KTRs’ susceptibility…
2021 American Transplant Congress
Are All DSA’s the Same? Are We Ready for Precision Medicine in Pediatric LT?
S. E. Shin¹, M. Lee¹, N. Yazigi², K. Khan², S. Kaufman², J. Ahn³, O. Timofeeva⁴, U. Ekong²
¹Georgetown University School of Medicine, Washington, DC, ²Medstar Georgetown Transplant Institute, Medstar Georgetown University Hospital, Washington, DC, ³Biostatistics, Bioinformatics, & Biomathematics, Georgetown University, Washington, DC, ⁴Histocompatibility Laboratory, Dept. of Pathology & Laboratory Medicine, Georgetown University, Washington, DC
*Purpose: Donor-specific antibodies (DSA) play an uncertain role in rejection after liver transplantation (LT). We hypothesized that evaluation of epitope differences in HLA-DR/DQ mismatching can…
2021 American Transplant Congress
Atg16l-Dependent Autophagy Attenuates Procession of Renal Interstitial Fibrosis in Chronic Renal Graft Dysfunction via Regulating Tumor Necrosis Factor Alpha (tnf-α) Induced Endmt
Z. Gui, Z. Wang, Z. Han, J. Tao, X. Ju, R. Tan, M. Gu
The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
*Purpose: Chronic renal graft dysfunction is characterized by inflammation, tubular injury, and interstitial fibrosis. We have confirmed that endothelial-mesenchymal transition (EndMT) was one of important…
2021 American Transplant Congress
Development of De Novo Antibody in Renal Transplant Recipients with BK Viremia Managed with Immunosuppression Reduction
R. Hod Dvorai¹, R. Lee², P. Muluhngwi², M. Raijmakers³, A. Shetty², A. Tambur², M. Ison²
¹SUNY Upstate Medical University, Syracuse, NY, ²Northwestern University, Chicago, IL, ³University of Santiago, Santiago, Chile
*Purpose: To evaluate development of de novo donor specific antibodies (dnDSA) in Renal Transplant Recipients (RTR) with immunosuppression (IS) modulation due to BK viremia (BKV)…
2021 American Transplant Congress
The Impact of the Covid-19 Pandemic on Measures of Transplant Activity is Higher in Lower-Income Countries: A Multinational Survey Study
S. Sandal¹, B. Boyarsky², P. Chiang², A. Massie², D. Segev², M. Cantarovich¹
¹McGill University, Montreal, QC, Canada, ²Johns Hopkins University, Baltimore, MD
*Purpose: The COVID-19 pandemic has affected the field of solid organ transplantation due to the “ramp-down” of activity during the initial months. Impact on transplant…
2021 American Transplant Congress
Journey to Transplant: A Pilot Feasibility Trial of a Virtual Counseling Intervention for Patients and Their Social Support Networks to Improve Access to Kidney Transplant
A. Hart¹, R. Edpuganti², H. D'Cunha², S. Kurschner², W. T. McKinney¹, A. Matas¹, R. Patzer¹, S. Chu¹, M. Bruin¹, M. Partin¹
¹Hennepin Healthcare, University of Minnesota, Minneaplis, MN, ²Hennepin Healthcare Research Institute, Minneaplis, MN
*Purpose: Home counseling interventions have shown promise in increasing rates of kidney transplant, but are challenging to implement. We piloted a structured but individualized virtual…