Am J Transplant, Volume 21, Suppl 3 Archives - Page 10 of 139 - ATC Abstracts

2021 American Transplant Congress
Characterizing Kidney Transplant Recipients with SARS-CoV-2: An Academic Single Center Experience
S. Nahi, A. Shetty, S. Tanna, J. Leventhal
Northwestern University, Chicago, IL
*Purpose: Kidney transplant (KTx) recipients are a unique cohort in regard to SARS-CoV-2 susceptibility and clinical course, owing to their immunosuppressed state and propensity for…
2021 American Transplant Congress
Drivers of Graft Failure in Pediatric Kidney Transplant Change Over Time
E. Benz¹, D. Schaubel², S. Amaral¹
¹Children's Hospital of Philadelphia, Philadelphia, PA, ²Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania, Philadelphia, PA
*Purpose: Short-term pediatric kidney transplant outcomes have improved over time with advanced surgical techniques and better immunosuppression, but long-term graft outcomes remain suboptimal - concerning…
2021 American Transplant Congress
Liver Kinase B1 Knockdown Induces Platelet-Derived Growth Factor Receptor B Expression in Human Airway Epithelial Cells: A Potential Mechanism for Development of Fibrosis Leading to Chronic Lung Allograft Dysfunction
M. Rahman, J. Lee, R. Ravichandran, T. Fleming, M. Smith, R. Bremner, T. Mohanakumar
St. Joseph’s Hospital and Medical Center, Phoenix, AZ
*Purpose: The platelet-derived growth factor and its receptor (PDGFRb) signaling pathway can be activated by epithelial mesenchymal transition which facilitates fibrosis. It is not known…
2021 American Transplant Congress
Centers Avoided 67% of Kidney Offers by Participating in the OPTN’s Multifactorial Offer Filter Pilot Project
A. Toll, H. McGehee, D. Stewart, R. McTier
Research, United Network for Organ Sharing, Richmond, VA
*Purpose: Evaluate if multifactorial filters can reduce unwanted kidney offers to centers, thereby reducing administrative burden and getting to the accepting candidate quicker.*Methods: 40 centers…
2021 American Transplant Congress
Changes to Adult Heart Allocation Improve Candidate Stratification
K. Bradbrook¹, K. Lindblad¹, R. R. Goff¹, R. Daly², S. Hall³
¹Research, United Network for Organ Sharing, Richmond, VA, ²Mayo Clinic, Rochester, MN, ³Baylor University Medical Center, Dallas, TX
*Purpose: Historically, heart allocation has been driven by waitlist (WL) mortality rather than post-transplant survival. On 10/18/2018 the Organ Procurement and Transplantation Network (OPTN) implemented…
2021 American Transplant Congress
COVID-19 Potential Donor Derived Transmission Events Investigations: Early DTAC Experience
R. La Hoz, A. Agarwal, S. Aslam, K. Dunn, J. Goldman, D. Levine, C. Marboe, G. F. Marklin, S. M. Pouch, M. Rana, R. Razonable, H. L. Stevenson, H. Te, A. E. Woolley, M. Michaels, L. Danziger-Isakov
OPTN DTAC, Richmond, VA
*Purpose: US Solid organ transplantation rates significantly decreased during the initial wave of the COVID-19 pandemic. The concern for potential donor derived COVID-19 was one…
2021 American Transplant Congress
A Novel Liver Assist Device as a Bridge to Liver Transplantation in Acute on Chronic Liver Failure Patients with Multi-Organ Failure
S. Ahmad¹, I. W. Liou¹, J. Reyes², R. Bakthavatsalam³, N. C. Smith⁴, R. L. Carithers¹, C. Martin¹, D. Gao⁵
¹Medicine, University of Washington, Seattle, WA, ²Surgery, University of Washington, SEATTLE, WA, ³Surgery, University of Washington, Seattle, WA, ⁴Nursing, University of Washington, Seattle, WA, ⁵Engineering, University of Washington, Seattle, WA
*Purpose: Acute on chronic liver failure (AOCLF) occurs in nearly 25% of patients with acutely decompensated cirrhosis, with many developing multi-organ failure requiring ventilatory, vasopressor…
2021 American Transplant Congress
Belatacept Pharmacokinetic Analysis Comparing Belatacept Early Steroid Withdrawal Trial (BEST) with Benefit and Benefit-ext Trials
A. Bickenbach¹, M. McGowan¹, B. Miyagawa², T. Mizuno², A. Shields³, A. Christianson¹, P. West-Thielke⁴, J. Leone⁵, E. Woodle¹, D. Kaufman⁶, A. Wiseman⁷, A. Matas⁸, A. Vinks²
¹U Cincinnati, Cincinnati, OH, ²Cincinnati Childrens Med Center, Cincinnati, OH, ³Christ Hospital, Cincinnati, OH, ⁴UIC, Chicago, IL, ⁵Tampa Gen, Tampa, FL, ⁶U Wisconsin, Madison, WI, ⁷Centura Transplant, Denver, CO, ⁸U Minnesota, Minneapolis, MN
*Purpose: Belatacept(BELA) pharmacokinetic(PK) studies informed dosing in phase 3 studies where fixed mg/kg dosing compared a less intense(LI) and more intense(MI) regimen. LI was preferred…
2021 American Transplant Congress
The Effect of Daratumumab (Dara, Humanized Anti-CD38 Monoclonal Antibody) on Immune Cells In Vitro and in a HLA-Sensitized Kidney Transplant Patient (HS KTx Pt) Desensitized (DES) with Dara
S. Ge¹, M. Chu¹, A. De Guzman¹, E. Ortiz¹, A. Vo², N. Ammerman², S. C. Jordan², M. Toyoda¹
¹Transplant Immunology Laboratory, Cedars Sinai Medical Center, Los Angeles, CA, ²Comprehensive Transplant Center, Cedars Sinai Medical Center, Los Angeles, CA
*Purpose: Antibody-Mediated Rejection (ABMR), primarily mediated by B cells, plasma cells (PC) and antibodies (Ab), is an obstacle for successful transplantation in HS KTx Pts.…
2021 American Transplant Congress
The Impact of Donor and Recipient Age Differenceon Long Term Prognosis in Young Liver Transplant Recipients
A. Pita, A. Moro, J. C. McVey, D. J. Firl, M. Fujiki, T. Diago, C. Quintini, F. Aucejo, C. D. Kwon, K. V. Menon, K. Hashimoto, B. Eghtesad, C. Miller, K. Sasaki
The Cleveland Clinic, Cleveland, OH
*Purpose: Although the importance of donor and recipient age in liver transplant (LT) are well-studied, the prognostic influences of donor and recipient age differences are…