Am J Transplant, Volume 21, Suppl 3 Archives - ATC Abstracts

2021 American Transplant Congress
Interruption of Notch Signaling via Blockade of Delta-Like Ligand 4 Prevents Co-Stimulation Blockade Resistant Allograft Rejection
A. J. Matar, B. P. Lovasik, Y. Dong, D. A. Faber, J. Habib, C. Breeden, J. Regenold, A. Ghosh, A. Stephenson, W. H. Kitchens, A. B. Adams
Emory University Department of Surgery, Atlanta, GA
*Purpose: Co-stimulation blockade (CoB) has emerged as a promising immunosuppression strategy with the advent of Belatacept, a novel CTLA4-Ig fusion protein that blocks CD28-mediated T…
2021 American Transplant Congress
Cost-Effectiveness Analysis of Short-Duration Anti-Viral Prophylaxis for Hepatitis C Positive Donor Kidney Transplants
I. Yakubu, Y. Zhang, S. Ijioma, N. V. Carroll, J. Patterson, R. Sterling, G. Gupta
Virginia Commonwealth University Health System, Richmond, VA
*Purpose: Trials describing 4-12 week courses of direct-acting anti-viral drugs (DAAs) to treat hepatitis C virus (HCV) transmission from infected donors to uninfected kidney transplant…
2021 American Transplant Congress
Donor Service Area Characteristics Impacting Liver and Kidney Deceased Donor Population
C. O. Warren, A. Zarrinpar
Surgery, -University of Florida, Gaiinesville, FL
*Purpose: While there is ample evidence of racial and ethnic disparities in access to the waitlist, being transplanted, and post-transplant outcomes in liver and kidney…
2021 American Transplant Congress
Relationship Between %dd-cfDNA, MMDx Molecular Diagnoses, and Donor-specific Antibody in the Trifecta Study
P. F. Halloran¹, L. G. Hildago², J. Reeve¹, Z. Demko³, A. Prewett³, P. Billings³, J. Truong⁴, P. Vander Horn⁴, &. Trifecta Study Group⁵
¹Alberta Transplant Applied Genomics Centre, Edmonton, AB, Canada, ²University of Wisconsin, Madison, WI, ³Natera Inc., San Carlos, CA, ⁴One Lambda Inc., West Hills, CA, ⁵., ., AB, Canada
*Purpose: The Trifecta Study is a prospective multicenter investigator-initiated trial to evaluate the relationship between %dd-cfDNA and molecular biopsy findings at the time an indication…
2021 American Transplant Congress
Waitlist Outcomes for Patients with Hepatocellular Carcinoma Following the 2019 Exception Policy Change
K. Young¹, C. Enestvedt², W. Naugler¹, E. Maynard², A. Mitra¹, M. Wungiranirun¹, J. Jou¹, J. Ahn¹, M. Chang¹, D. Lhewa¹
¹Division of Gastroenterology and Hepatology, OHSU, Portland, OR, ²Division of Abdominal Organ Transplant, OHSU, Portland, OR
*Purpose: We aim to compare waitlist (WL) outcomes for HCC patients after the implementation of the most recent UNOS exception policy change on 5/1/2019.*Methods: All…
2021 American Transplant Congress
Review of Unos Report of Organ Offers is Supplemented with Documented Real-time Communication Messages
E. S. Pahl¹, N. Patterson²
¹University of Iowa, Iowa City, IA, ²Iowa Methodist, Des Moines, IA
*Purpose: Use real time group messaging data among procurement and transplant professionals to supplement the review of UNOS Report of Organ Offers (ROO) for declined…
2021 American Transplant Congress
Association Between Donor-Recipient Genetic Matching and Acute Rejection in Kidney Transplantation
R. Cao¹, V. Arthur², J. Chen², B. Keating², C. Dorr³, D. Schladt³, G. Onyeaghala³, R. Mannon⁴, A. Matas¹, R. Remmel¹, N. Pankratz¹, B. Wu¹, W. Oetting¹, P. Jacobson¹, A. Israni³, W. Guan¹
¹University of Minnesota, Minneapolis, MN, ²University of Pennsylvania, Philadelphia, PA, ³Hennepin Healthcare Research Institute, Minneapolis, MN, ⁴University of Nebraska, Omaha, NE
*Purpose: In this study we carried out a genome-wide association study (GWAS) between donor-recipient matching scores at individual SNP level and Acute rejection (AR) in…
2021 American Transplant Congress
Properties of Regulatory B Cells Suppressing B Cells
Q. Fu¹, K. Lee², K. Deng², G. Huai², C. Rickert², H. Yang¹, C. LeGuern², S. Deng¹, J. F. Markmann²
¹Organ Transplantation Center, Sichuan Provincial People's Hospital, University of Electronic Sciences and Technology of China, Chengdu, China, ²Center for Transplantation Sciences, MGH, Boston, MA
*Purpose: Our previous study showed that TLR-Bregs, regulatory B cells generated in vitro through TLR activation, suppressed naïve B cell proliferation triggered by a mitogen…
2021 American Transplant Congress
Enhancement of Regulatory T Cell Therapies by Biomimetic Nanofiber Matrices on Single Cells
L. A. Fraser¹, S. Lee¹, Y. Sambandam², J. He², X. Huang², D. Z. Ivancic², J. Mathew², Z. J. Zhang², J. R. Leventhal², L. Gallon², S. I. Stupp¹
¹Simpson Querrey Institute, Northwestern, Chicago, IL, ²Surgery – Comprehensive Transplant Center, Northwestern, Chicago, IL
*Purpose: Here we report a new method to create an artificial and biodegradable matrix of biomimetic nanofibers on single cells with the goal of enhancing…
2021 American Transplant Congress
Treg Lymphotoxin Engages Lymphotoxin Receptor on Cancer and Endothelial Cells to Promote Cancer Metastatic Migration: Mechanisms for Treg-Cancer Interactions
W. Piao, R. Oakes, C. Paluskievicz, J. Christopher, J. Bromberg
U Maryland, Baltimore, MD
*Purpose: Treg immune suppression which is critical for transplant graft survival may also enhance tumor growth and metastases. Treg lymphotoxin (LTα1β2) may directly engage the…

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