2020 American Transplant Congress
Vaccine Safety Concerns and Relationship to Comfort with Provider Communication in a Population of Inner-City Kidney Transplant Recipients
SUNY Downstate Medical Center, Brooklyn, NY
*Purpose: Misperceptions and incorrect beliefs among patients may contribute to patient refusal of vaccines. We examined beliefs and sources of information in a population of…2020 American Transplant Congress
Post Heart Transplant Outcomes for Patients with Cardiac Sarcoidosis
*Purpose: Cardiac sarcoidosis (CS) is a known etiology of end-stage dilated, hypertrophic, or arrhythmogenic cardiomyopathies requiring heart transplantation (HT). We sought to evaluate the long-term…2020 American Transplant Congress
Effects of Alpha-1 Proteinase Replacement Continuation Post-Lung Transplantation in Alpha-1 Antitrypsin Deficiency: A Single Center Case Series
Lung Transplant, University of California San Diego, La Jolla, CA
*Purpose: Alpha-1 antitrypsin deficiency (AATD) accounts for approximately 6% of all lung transplants (LTx) performed annually. The benefit of replacement with alpha-1 proteinase inhibitor (A1-PI)…2020 American Transplant Congress
Evaluation of the Mitra Microsampling Device for TTV Measurement in Human Whole Blood of Lung Transplant Recipients
*Purpose: The apathogenic Torque Teno Virus (TTV) is highly prevalent among solid organ transplant recipients and mirrors the immunocompetence of its host. qPCR based measurement…2020 American Transplant Congress
Donor-Derived Cell-Free DNA May Not Discriminate Rejection in Kidney Transplant Recipients with a Prior Allograft in Place
*Purpose: Donor-derived cell-free DNA (dd-cfDNA) is an injury biomarker discriminating rejection in kidney transplant (KTx) patients (pts). However, its performance when stratified by rejection risk…2020 American Transplant Congress
Single Cell RNA Sequencing of Murine Kidney Allografts Identifies Macrophage Gene Signature Associated with Acute Rejection
*Purpose: Evaluating kidney allografts using single cell RNA sequencing (scRNAseq) can provide a comprehensive qualitative and quantitative gene expression data on thousands of individual cells.…2020 American Transplant Congress
Anti-CD321 Antibody (90G4) Protects Liver against Ischemia Reperfusion Injury in a Murine Model
*Purpose: Ischemia reperfusion results in increased transmigration of leukocytes into tissue. This eventually leads to post transplant graft damage after organ transplantation. CD321 (also known…2020 American Transplant Congress
IL-10 Exposure Enhances IRAK-M Expression to Promote Endotoxin Tolerance and the T Cell Tolerogenic Potential of Liver Conventional DCs
Surgery, Starzl Transplantation Institute, Pittsburgh, PA
*Purpose: Liver conventional myeloid (m)DC contribute to liver transplant tolerance. When freshly-isolated, they produce low levels of IL-12 but high levels of IL-10 compared with…2020 American Transplant Congress
Circulating Exosomes with Cardiac Self-Antigens, Myosin and Vimentin, Induced Immune Responses Leading to Rejection Following Heterotopic Cardiac Transplantation Immunosuppressed with mTOR Inhibitor and Low Dose of IL-2 Therapy
Norton Thoracic Institute, St. Joseph’s Hospital and Medical Center, Phoenix, AZ
*Purpose: The aim of the study is to determine the role for circulating exosomes with cardiac self-antigens (SAgs) (Myosin, Vimentin) in the development of immune…2020 American Transplant Congress
High PRA Increases Rejection but Does Not Worsen Renal Function in the First Year Post Kidney Transplant with Alemtuzumab Induction
Ochsner Medical Center, New Orleans, LA
*Purpose: Sensitization is an important immunologic risk factor considered in renal allograft allocation and influences immunosuppression. Unfortunately, there is a lack of consensus regarding the…
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