Am J Transplant, Volume 20, Suppl 3 Archives - Page 28 of 223 - ATC Abstracts

2020 American Transplant Congress
The Therapeutic Potential of Human Liver-Derived Stem Cells Transplantation in Carbon Tetrachloride-Induced Rat Liver Cirrhotic Model
S. Lee¹, J. Lee², H. Park², Y. Kim², S. Lee¹
¹Department of Surgery, Samsung Medical Center, Seoul, Korea, Republic of, ²Stem Cell and Regenerative Medicine Center, Research Institute for Future Medicine, Samsung Medical Center, Seoul, Korea, Republic of
*Purpose: Cirrhosis is a long-term consequence of chronic hepatic injury and there are no effective treatment methods. Mesenchymal stem cells (MSCs) have been reported to…
2020 American Transplant Congress
Characterization of Non HLA Antibodies in Kidney Transplant Recipients
S. Rodriguez Ramirez¹, S. Clotet-Freixas¹, C. Mcevoy¹, M. Kotlyar², I. Jurisica², A. Chruscinski¹, A. Konvalinka³
¹Kidney Transplant, Toronto General Hospital Research Institute, Multi-Organ Transplant Program, University Health Network, Toronto, ON, Canada, ²Kidney Transplant, Krembil Research Institute, University Health Network, Toronto, ON, Canada, ³Kidney Transplant, Department of Medicine, Division of Nephrology, University Health Network, Toronto, ON, Canada
*Purpose: Antibody mediated rejection (AMR) causes more than 60 percent of late graft failures in kidney transplants (KT). Although antiHLA donor specific antibodies are the…
2020 American Transplant Congress
Targeting the CD40/CD40L Axis in Sensitized Nonhuman Primate Allotransplantation
Z. W. Fitch, R. Schmitz, M. Manook, A. Y. Choi, J. Yoon, J. Kwun, S. J. Knechtle
Duke University, Durham, NC
*Purpose: Blockade of the CD28/B7 costimulation pathway has shown great promise as part of desensitization and maintenance immunosuppression regimens in our sensitized nonhuman primate model.…
2020 American Transplant Congress
A Single-Cell Transcriptome Atlas of 15 Adult Human Organs
Z. Guo¹, S. He², L. Wang¹, Y. Liu², J. Xu¹, J. Bei², X. He¹
¹Organ Transplant Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China, ²The Cancer Centre of Sun Yat-Sen University, Guangzhou, China
*Purpose: The transcriptome diversity of cell types within and across tissues is of great importance for biological function of human beings. Here we conducted a…
2020 American Transplant Congress
Aging Aggravated Liver Ischemia and Reperfusion Injury by Promoting Sting-Mediated NLRP3 Activation in Macrophages
Z. Rao, W. Zhong, H. Zhou, P. Wang, X. Wang, L. Lu
The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
*Purpose: Aggravated liver injury and enhanced intrahepatic inflammation was found in old livers post ischemia and reperfusion (IR). However, the function and underlying mechanism of…
2020 American Transplant Congress
The Role of CXCL16/CXCR6 in Mediating Macrophage Chemotaxis and M1 Macrophage Polarization in Murine Renal Ischemia Reperfusion Injury
W. Zhang¹, X. Zhang², G. Tu², C. Yang¹, G. Qi¹, M. Xu¹, T. Zhu¹
¹Department of Urology, Zhongshan Hospital, Fudan University, Shanghai, China, ²Department of Critical Care Medicine, Zhongshan Hospital, Fudan University, Shanghai, China
*Purpose: The objective of this study is to investigate the role of Chemokine (C-X-C motif) ligand 16 (CXCL16) and its unique receptor C-X-C chemokine receptor…
2020 American Transplant Congress
Does Hope for a Better Future or Fear of Death Motivate Kidney Patients More? A Decisional Balance Exploration of Motivation to Pursue Living Donor Kidney Transplant
H. Rafiqzad¹, A. Wasim¹, A. Rezaeishahreza¹, J. Lam¹, A. Li¹, T. Mahiuddin¹, A. D. Waterman², M. Novak¹, I. Mucsi¹
¹University Health Network, Toronto, ON, Canada, ²University of California, Los Angeles, Los Angeles, CA
*Purpose: We assessed whether the importance attributed to “living a longer life with transplant” versus “fear of death during transplant surgery” by kidney transplant (KT)…
2020 American Transplant Congress
Crosstalk between TLR4 and HLA Class I Mediates P-Selectin Expression and Monocyte Capture to Endothelial Cells
Y. Jin, N. M. Valenzuela, R. A. Sosa, E. F. Reed
Pathology and Laboratory Medicine, University of California Los Angeles, Los Angeles, CA
*Purpose: Transplant recipients developing donor specific HLA antibodies (DSA) are at risk for acute and chronic antibody-mediated rejection (AMR). DSA contribute to the process of…
2020 American Transplant Congress
Anti-Thymocyte Globulin versus Interleukin-2 Receptor Antagonist and Deceased-Donor Kidney Transplant Outcomes among Older Recipients
J. Ahn¹, S. Bae¹, K. Lentine², M. Schnitzler², G. Hess³, D. Segev¹, M. McAdams-DeMarco¹
¹Johns Hopkins University, Baltimore, MD, ²Saint Louis University, St. Louis, MO, ³Drexel University, Philadelphia, PA
*Purpose: Kidney transplantation (KT) has been growing treatment option for older end-stage renal disease patients. Although lymphocyte-depleting agents are considered to be superior than interleukin-2…
2020 American Transplant Congress
Wage Reimbursement by the NKR: A Critical Step Towards Financial Neutrality for Living Kidney Donors
N. Garg¹, T. D’Alessandro², M. Ronin², A. D. Waterman³, M. Cooper⁴, G. Hil², D. A. Mandelbrot¹
¹UW-Madison, Madison, WI, ²NKR, Babylon, NY, ³UCLA, Terasaki Research Institute, Los Angeles, CA, ⁴Georgetown University, Washington, DC
*Purpose: The potential for out-of-pocket expenses incurred by living kidney donors has been identified as an important barrier to proceeding with live donation, with financial…