Am J Transplant, Volume 20, Suppl 3 Archives - Page 28 of 223 - ATC Abstracts

2020 American Transplant Congress
Male Native Hawaiians and Pacific Islanders are at Risk for Delayed Graft Function after Renal Transplantation
L. Lee¹, K. Bozhilov², L. L. Wong²
¹The Queen's Transplant Center, Honolulu, HI, ²Surgery, University of Hawaii - John A. Burns School of Medicine, Honolulu, HI
*Purpose: Native Hawaiians and Pacific Islanders (NHPI) have an increased risk of chronic kidney disease with disproportionately fewer patients receiving kidney transplants; this study aims…
2020 American Transplant Congress
Normothermic Ex Vivo Perfusion of Marginal Liver Grafts Rapidly Stimulates Release of Graft-Derived Exosomes and Markedly Decreases the Inflammatory Pathways Induced at Early Times after Transplant Reperfusion
K. E. Brown¹, K. S. Keslar¹, D. Margeta¹, Q. Liu², A. Simioni², L. Del Angel Diaz², W. M. Baldwin¹, R. L. Fairchild¹, C. Quintini²
¹Lerner Research Institute, Cleveland Clinic, Cleveland, OH, ²Transplant Center, Cleveland Clinic, Cleveland, OH
*Purpose: Normothermic ex vivo machine perfusion of liver grafts (EVLP) is emerging as a superior preservation technology to cold storage. Normothermic EVLP transforms a metabolically…
2020 American Transplant Congress
Pre-Transplant Pharmacogenetics Identifies CYP3A4 and CYP3A5 Heterogeneity among Caucasian Kidney Transplant Recipients
N. Oliver¹, L. Lindberg¹, S. LeCorchick¹, D. Morris¹, S. Anand¹, T. Srinivas²
¹Intermountain Medical Center, Murray, UT, ²University Hospitals Cleveland Medical Center, Cleveland, OH
*Purpose: Tacrolimus has always been dosed based on therapeutic drug monitoring, however pharmacogenomics is becoming increasingly more utilized in the era of precision based medicine…
2020 American Transplant Congress
Informed Consent and Decision Making for Upper Extremity VCA
B. Kuramitsu¹, C. Berumen¹, A. Ferzola², H. Sung², C. Kim³, D. Scarton³, T. McHugh³, A. Schultheis³, T. Riggleman³, J. Taylor³, M. Henderson², G. Brandacher², S. Tintle³, E. Gordon¹
¹Northwestern U Feinberg Sch of Medicine, Chicago, IL, ²Johns Hopkins School of Medicine, Baltimore, MD, ³Walter Reed National Military Medical Center, Bethesda, MD
*Purpose: The field of upper rxtremity (UE) Vascularized Composite Allotransplantation (VCA) continues to advance with more patients undergoing the informed consent process each year. However,…
2020 American Transplant Congress
Precision Dosing for Tacrolimus Using Genotypes and Clinical Factors
M. Al-Kofahi¹, W. Oetting¹, A. Israni², D. Schladt³, W. Guan⁴, B. Wu⁴, C. Dorr⁵, R. Remmel⁶, R. Mannon⁷, N. Pankratz⁸, A. Matas⁹, P. Jacobson¹
¹Experimental and Clinical Pharmacology, Univ of MN, College of Pharmacy, Minneapolis, MN, ²Nephrology, Univ of MN and Hennepin HealthCare, Minneapolis, MN, ³Hennepin HealthCare Research Institute, Hennepin HealthCare, Minneapolis, MN, ⁴Biostatistics, Univ of MN, Minneapolis, MN, ⁵Nephrology, Hennepin HealthCare, Minneapolis, MN, ⁶Medicinal Chemistry, Univ of MN, College of Pharmacy, Minneapolis, MN, ⁷Nephrology, Univ of Alabama, Minneapolis, MN, ⁸Lab Medicine Pathology, Univ of MN, Minneapolis, MN, ⁹Surgery, Univ of MN, Minneapolis, MN
*Purpose: Variants in CYP3A4/5 genes, clinical factors and drug-drug interactions are associated with tacrolimus (TAC) clearance and dose. This results in high intra- and inter-…
2020 American Transplant Congress
Kidney Transplantation in Inherited Kidney Diseases
Y. Caliskan¹, H. Yazici², R. Ouseph¹, Y. Ozluk³, H. Randall⁴, E. Demir², F. Savran Oguz⁵, A. Turkmen², M. S. Sever², K. Lentine¹
¹Division of Nephrology, Saint Louis University, Saint Louis, MO, ²Division of Nephrology, Istanbul Faculty of Medicine, Istanbul, Turkey, ³Department of Pathology, Istanbul Faculty of Medicine, Istanbul, Turkey, ⁴Center for Abdominal Transplantation, Saint Louis University, Saint Louis, MO, ⁵Department of Medical Biology, Istanbul Faculty of Medicine, Istanbul, Turkey
*Purpose: We aimed to evaluate the kidney transplant (KTx) recipients with inherited kidney diseases and investigate the causal genetic variants in recipients with undetermined etiology.*Methods:…
2020 American Transplant Congress
Hepatic Microenvironment: Molecular and Chemical Changes Associated with Preconditioning Maneuvers
I. Lies, C. Watkins, M. Em, J. D. Eason, C. Eynard, T. Rousselle, V. R. Mas, D. Maluf
Dept of Surgery, Transplant Research Institute, James D. Eason Transplant Institute, University of Tennessee Health Science Center, Memphis, TN
*Purpose: Liver preconditioning has been described to protect liver from ischemia injury and trigger liver regeneration. Hereby, we aimed to assess the effect of preconditioning…
2020 American Transplant Congress
The Therapeutic Potential of Human Liver-Derived Stem Cells Transplantation in Carbon Tetrachloride-Induced Rat Liver Cirrhotic Model
S. Lee¹, J. Lee², H. Park², Y. Kim², S. Lee¹
¹Department of Surgery, Samsung Medical Center, Seoul, Korea, Republic of, ²Stem Cell and Regenerative Medicine Center, Research Institute for Future Medicine, Samsung Medical Center, Seoul, Korea, Republic of
*Purpose: Cirrhosis is a long-term consequence of chronic hepatic injury and there are no effective treatment methods. Mesenchymal stem cells (MSCs) have been reported to…
2020 American Transplant Congress
Ex Vivo Generated Regulatory B Cells Can Suppress Donor-Specific CD4 T Cells Proliferation In Vivo
G. Huai¹, K. M. Lee¹, Q. Fu¹, K. Deng¹, N. J. Feeney¹, C. Leguern¹, N. Tanimine¹, C. G. Rickert¹, S. Deng², J. F. Markmann¹
¹Center for Transplantation Sciences, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ²Organ Transplantation Center, Sichuan Provincial People's Hospital and School of Medicine, University of Electronic Science and Technology of China, Chengdu, China
*Purpose: B cells expanded in vitro via TLR9 agonist CpG and activated by LPS, PMA and ionomycin have been previously denoted “TLR-Bregs” by our team.…
2020 American Transplant Congress
Characterization of CpG-stimulated, Tlr Regulatory, and Expanded Regulatory B Cells by RNA-Seq
Q. Fu, G. C. Rickert, K. Lee, G. Huai, K. Deng, N. Feeney, N. Tanimine, A. Cuenca, S. Deng, J. F. Markmann
Center for Transplant Science, MGH, Boston, MA
*Purpose: Our group previously reported three different types of in vitro generated B cell populations. Expanded regulatory B cells (eBregs), TLR regulatory B cells (TLR-Bregs),…