Am J Transplant, Volume 20, Suppl 3 Archives - Page 23 of 223 - ATC Abstracts

2020 American Transplant Congress
Bypassing the Nearest Transplant Center for Care is Associated with Gains in Time to Living Donor but Not Deceased Donor Kidney Transplantation or Improved Graft Outcomes
A. M. Whelan¹, C. McCulloch², E. Ku¹
¹Division of Nephrology, University of California San Francisco (UCSF), San Francisco, CA, ²Department of Epidemiology and Biostatistics, UCSF, San Francisco, CA
*Purpose: Some patients may gain an advantage if they choose to bypass their local transplant center and receive care at a center further away but…
2020 American Transplant Congress
Sensitization via Pregnancy Generates Alloantibody and Cross-Reactive Xeno-Antibody in a Non-Human Primate Model
J. Yoon, M. Manook, Z. Fitch, R. Schmitz, A. Choi, A. M. Jackson, S. Knechtle, J. Kwun
Surgery, Duke University, Durham, NC
*Purpose: Women are disproportionately represented among highly sensitized waitlist candidates and within HLA-incompatible transplantation programs. Due to difficulties obtaining compatible donors, sensitized patients are seen…
2020 American Transplant Congress
Comparing Two Methods of Minimally-Ischemic Cardiac Preservation in Life-Supporting Cardiac Xenotransplantation Model
C. E. Goerlich¹, A. Singh¹, D. Kaczorowski¹, M. Abdullah¹, B. Lewis¹, I. Tatarov¹, A. Hershfeld¹, T. Zhang¹, E. Strauss¹, P. Odonkor¹, B. Williams¹, D. Ayares², B. Griffith¹, M. Mohiuddin¹
¹Surgery, University of Maryland School of Medicine, Baltimore, MD, ²Surgery, Revivicor, Blacksburg, VA
*Purpose: Transplantation of organs from animals to humans (xenotransplantation) has been proposed to address the critical shortage of organs for transplantation. The use of genetically…
2020 American Transplant Congress
Increased Intra-Abdominal Pressure is Associated with Delayed Graft Function after Kidney Transplantation
A. Coca¹, C. Arias-Cabrales², M. Perez-Saez², P. Gonzalez¹, M. Crespo², M. Rollan¹, B. Toribio¹, A. Mendiluce¹, J. Pascual², J. Bustamante-Munguira³
¹Nephrology, Hospital Clínico Universitario, Valladolid, Spain, ²Nephrology, Hospital Del Mar, Barcelona, Spain, ³Cardiac Surgery, Hospital Clínico Universitario, Valladolid, Spain
*Purpose: Increased intra-abdominal pressure (IAP) is a common complication among critically ill and post-surgical patients that can cause organ dysfunction. Its prevalence and effects after…
2020 American Transplant Congress
Hepatocyte Growth Factor (HGF) Prevents the Apoptotic and Anti-Angiogenic Effect of Hypercholesterolemia on Hepatocytes in Liver Allografts
H. B. Ozdemir¹, G. Ozgun¹, A. Yucel Polat¹, N. Haberal¹, G. Moray², M. Haberal²
¹Pathology, Baskent University, Ankara, Turkey, ²Department of General Surgery, Division of Transplantation, Baskent University, Ankara, Turkey
*Purpose: Background: Hypercholesterolemia (HC) impairs angiogenesis and induces apoptosis in livers. This hyperlipidemic impairment of angiogenesis reported associated with reduced bFGF. HGF stimulates proliferation, angiogenesis,…
2020 American Transplant Congress
Significance of Gene Polymorphism on Infectious Complications and Rejection after Liver Transplantation
H. Egawa¹, T. Kato¹, Y. Kotera¹, A. Ohmori¹, G. Shibuya¹, S. Yamashita¹, S. Ariizumi¹, M. Yamamoto¹, T. Ishizuka², Y. Tanaka³, H. Ohdan³
¹Tokyo Women's Medical University, Tokyo, Japan, ²Clinical Labotratory, Tokyo Women's Medical University, Tokyo, Japan, ³Surgery, Hiroshima University, Hiroshima, Japan
*Purpose: Clinical application of gene polymorphism is a key of precision medicine in the field of organ transplantation. Infection and rejection are major factors affecting…
2020 American Transplant Congress
Is it Time for Immune Screening for Belatacept-Treated Stable Kidney Transplant Patients for Adjust the Immunosuppression?
M. C. Rial¹, F. Caro², N. Ambrosi², D. Guerrieri², A. Calleri¹, E. Chuluyan¹, D. Casadei¹
¹ITAC, Buenos Aires, Argentina, ²CEFYBO, UBA, Buenos Aires, Argentina
*Purpose: Belatacept is a co-stimulation blocker for primary maintenance immunosuppression in kidney transplant recipients. The goal of this work was to study the immunological status…
2020 American Transplant Congress
Polyfunctional Cytokine Secreting Th17 Cells Preferentially Infiltrate Murine Renal Allografts with Acute Rejection and Are Associated with Elevated Th17: Treg Ratio
R. Dhital¹, V. Velazquez¹, Q. Zeng², M. Shimamura¹
¹Center for Vaccines and Immunity, Nationwide Children's Hospital, Columbus, OH, ²Center for Cardiovascular Research, Nationwide Children's Hospital, Columbus, OH
*Purpose: Our group has shown that renal transplant patients with acute rejection have elevated blood mRNA RORγt: FOXP3 ratio compared to patients with stable graft…
2020 American Transplant Congress
Human Organ Culture: A Novel Method for Evaluation of Reperfusion Injury in Human Kidney
J. T. Langford¹, C. Edwards¹, J. DiRito², M. Harris¹, S. A. Hosgood³, M. L. Nicholson³, J. S. Pober⁴, D. Haakinson¹, G. T. Tietjen¹
¹Department of Surgery, Yale School of Medicine, New Haven, CT, ²Department of Biomedical Engineering, Yale University, New Haven, CT, ³Department of Surgery, University of Cambridge, Cambridge, United Kingdom, ⁴Department of Immunobiology, Yale School of Medicine, New Haven, CT
*Purpose: Evaluate the ability of human organ culture to assess protein secretion during a model of reperfusion injury.*Methods: Biopsies are obtained from transplanted-declined human kidneys…
2020 American Transplant Congress
Neonatal Tolerance Induction: Behaviours of Allogeneic Spleen and Bone Marrow Inocula in Neonatal Mice are Largely Determined by the Nature of Their CD8 T Cells
R. A. Bascom, K. Tao, L. J. West
University of Alberta, Edmonton, AB, Canada
*Purpose: Injected adult allo-spleen (SC) and bone marrow cells (BMC) traffic to secondary lymphoid organs, proliferate and spread throughout neonatal mice; allo-SC consistently cause acute…