2020 American Transplant Congress
Ion AmpliSeq RNA Expression Panel Evaluated by Next-Generation Sequencing (NGS) Can Detect Genes in Human Formalin-Fixed Paraffin-Embedded Kidney Biopsies to Predict T Cell and Antibody Mediated Rejection in Renal Allografts
1Surgery, University of Miami, Miami, FL, 2University of Miami, Miami, FL
*Purpose: Optimization of effective anti-rejection therapies to prevent allograft rejection and to minimize drug toxicity may be aided by utilizing in situ biomarkers for detection…2020 American Transplant Congress
The Composite Molecular and Cellular Instability Score Identifies the Sub-Phenotypes of Histologically Stable Kidney Transplants
Department of Surgery, BCHSI, University of California San Francisco, San Francisco, CA
*Purpose: Recent molecular studies have highlighted the unrecognized burden of sub-clinical graft rejection of a histologically stable allograft, defined as transplants with absence of clinical…2020 American Transplant Congress
Mir-124/ire-1α Affects Renal Ischemia/Reperfusion Injury by Regulating Endoplasmic Reticulum Stress in Renal Tubularepithelial Cells
*Purpose: In this study, we investigated the protective functions of miR-124 on renal I/R injury both in vivo and in vitro and explored its underlying…2020 American Transplant Congress
HLA Cross-Dressing of Dendritic Cells by Maternal Exosomes is Associated with PD-L1 Expression in Newborns
1University of Wisconsin-Madison, Madison, WI, 2Fred Hutchinson Cancer Research Center, Seattle, WA
*Purpose: Recipients of a kidney transplant from a haplo-identical sibling had accelerated early acute rejection episodes, followed by improved long-term graft survival if the transplant…2020 American Transplant Congress
Single Cell RNA Sequencing Analysis of 3 Human Living-Donor Liver Transplant Allograft Biopsies after Infusion of Donor-Derived Regulatory Dendritic Cells
*Purpose: Single-cell RNA sequencing is an emerging, powerful genomic technology that can describe heterogenous cellular populations of whole solid organs with high resolution. We report…2020 American Transplant Congress
The Challenge of Selecting an Induction Agent: A Dual Regimen for Medically High-Risk Kidney Recipients
Weill Cornell Medical Center, New York, NY
*Purpose: Complications of the commonly used lymphocyte-depleting induction agent, rabbit anti-thymocyte globulin (rATG),include cardiorespiratory dysfunction with hypotension, tachycardia, myocardial infarction, and pulmonary edema. The choice…2020 American Transplant Congress
Maximizing Utilization of Marginal Kidneys in a Small, Geographically Isolated Transplant Program: 10 Year Experience
Charleston Area Medical Center, Charleston, WV
*Purpose: The initial experience with the kidney allocation system (KAS) resulted in an alarming decrease in the number of transplants in our small and isolated…2020 American Transplant Congress
Long-Term Effect of Kidney Transplantation on Peripheral Arterial Disease
*Purpose: Peripheral arterial disease (PAD) that needs treatment is common and major complication in patients with chronic kidney disease (CKD). Most surgeons have been using…2020 American Transplant Congress
Transplant Center Experiences with Social Media Campaigns for Living Donation
*Purpose: The OPTN Living Donor Committee surveyed U.S. transplant (TX) programs to assess their experiences with social media campaigns intended to identify potential living donors…2020 American Transplant Congress
Use of Angiotensin Converting Enzyme Inhibitors and Angiotensin II Receptor Blockers Therapy Prior to Kidney Transplantation Does Not Impact Recovery of Function
*Purpose: The impact of chronically administered medications for renin-angiotensin-aldosterone blockade (e.g. ACE-I, ARB), taken prior to kidney transplant (KTx), on immediate allograft function is unknown.*Methods:…
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