Am J Transplant, Volume 20, Suppl 3 Archives - Page 107 of 223 - ATC Abstracts

2020 American Transplant Congress
Anticipated Observations: The Role of DQ Antigen Frequencies among Donors and Recipients in a Pediatric Renal Transplant Cohort
S. Gattis¹, R. George², R. Liverman³, A. Serluco³, R. Garro², J. Figueroa², R. A. Bray², H. M. Gebel², H. C. Sullivan²
¹Emory Healthcare, Atlanta, GA, ²Emory University School of Medicine, Atlanta, GA, ³Children's Healthcare of Atlanta, Atlanta, GA
*Purpose: Donor specific HLA antibodies (DSA) that develop in the face of donor-recipient HLA mismatches are well-established independent predictors of graft loss in solid organ…
2020 American Transplant Congress
Utilization of Kidneys with Microthrombi and Acute Kidney Injury
W. De Faria, E. Shipman, G. Ciancio, G. Guerra
Miami Transplant Institute, Miami, FL
*Purpose: Kidneys continue to be discarded for reasons such as surgical damage, high kidney donor profile index (KDPI), prolonged cold ischemia time, and acute kidney…
2020 American Transplant Congress
Donor-Specific B Cell Frequency Assessed by a Novel Multiplex Bead-Based Assay Predicts Graft Failure in Kidney Transplant Recipients
Z. Ilyas, A. Akl, D. Pinelli, L. Gallon, A. R. Tambur, M. Ansari
Northwestern University Feinberg School of Medicine, Chicago, IL
*Purpose: Kidney transplant recipients with sensitization to HLA defined by a high percentage of Panel Reactive Antibodies (PRA) or Donor-specific anti-HLA antibodies (DSA) are at…
2020 American Transplant Congress
The Transcriptomic Analysis Revealed a Clear Deregulation of the C1QB Gene in Peripheral Blood Mononuclear Cells of Renal Transplant Patients with Chronic Antibody Mediated Rejection
G. Zaza¹, S. Granata¹, G. Santoro¹, C. Caletti¹, P. Pontrelli², F. Rascio³, M. Rossi¹, S. Andrighetto¹, G. Grandaliano⁴
¹Department of Medicine, Renal Unit, University/Hospital of Verona, Verona, Italy, ²Department of Emergency and Organ Transplantation-Nephrology Unit, University of Bari, Bari, Italy, ³Nephrology, Dialysis and Transplantation Unit, Department of Medical and Surgical Sciences, University of Foggia, Foggia, Italy, ⁴Università Cattolica del Sacro Cuore, Roma, Italy
*Purpose: Chronic antibody-mediated rejection (CAMR) is a multi-factorial pathological condition that can affect more that 40-50% of kidney transplanted recipients. Its clinical evolution is often…
2020 American Transplant Congress
Effector Differentiation of Endogenous Antigen-Specific CD8⁺ T Cells is Selectively Limited by CTLA-4 Ig
S. M. Krummey, K. P. Tong, M. L. Ford
Emory Transplant Center, Emory University School of Medicine, Atlanta, GA
*Purpose: Costimulation blockade with belatacept (CTLA-4 Ig) offers improved renal function and reduced toxicity following transplantation compared to calcineurin inhibitors. Nonetheless, episodes of acute T…
2020 American Transplant Congress
The Role of Galectin-1 and Basement Membrane Remodeling in Kidney Antibody-Mediated Rejection
S. Clotet-Freixas¹, C. McEvoy¹, I. Batruch², M. Kotlyar³, C. Pastrello³, J. Van¹, M. Arambewela¹, A. Boshart¹, S. Farkona¹, A. Bozovic⁴, V. Kulasingam⁴, P. Chen¹, I. Jurisica³, A. Chruscinski¹, R. John⁴, A. Konvalinka⁵
¹Toronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada, ²Department of Laboratory Medicine and Pathobiology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada, ³Krembil Research Institute, University Health Network, Toronto, ON, Canada, ⁴Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada, ⁵Department of Medicine, Division of Nephrology, University Health Network, Toronto, ON, Canada
*Purpose: Antibody-mediated rejection (AMR), the leading cause of kidney graft loss, is caused by anti-HLA and non-HLA antibodies against proteins in two main kidney compartments:…
2020 American Transplant Congress
XBP1 Modulates Endoplasmic Reticulum and Mitochondria Crosstalk via Regulating NLRP3 Inflammasome in Renal Ischemia/Reperfusion Injury
H. Ni¹, Y. Liu¹, W. Deng¹, J. Zhang², J. Xu¹, W. Zeng¹, N. Gong², Y. Miao¹
¹Organ Transplant Department, Nanfang Hospital, Southern Medical University, Guangzhou, China, ²Institute of Organ Transplantation, Key Laboratory of the Ministry of Health and the Ministry of Education, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
*Purpose: This study aims to investigate the molecular mechanism and function of X-box binding protein 1 (XBP1)- NLR family pyrin domain-containing 3 (NLRP3) signaling which…
2020 American Transplant Congress
Effects of Preoperative Intrathecal Morphine on Postoperative Pad in Living Donor Kidney Transplantation Recipients
K. Lee, M. Lim, J. Kwon, E. Jeong, J. Yang, M. Kim, J. Park
Samsung Medical Center, Seoul, Korea, Republic of
*Purpose: Postoperative PAD (pain, agitation, delirium), especially delirium in living donor kidney transplantation (LDKT) recipients is a risk factor for increased morbidity, duration of hospital…
2020 American Transplant Congress
Short Term Outcomes in Kidney Transplant Patients Receiving De Novo Belatacept with Anti-Thymocyte Globulin Induction
B. Carlson, P. Cabrera, T. Harrison, K. Tejani, A. Centeno
Pharmacy, Jackson Memorial Hospital, Miami, FL
*Purpose: Mainstay immunosuppressive therapy after kidney transplant is a calcineurin inhibitor (CNI) based regimen. Nephrotoxicity is a common adverse effect of CNIs which can lead…
2020 American Transplant Congress
Telehealth Medicine: A Novel Tool to Make Living Donation Simple and Financially Neutral
A. Yadav, M. Cantarin Martinez, P. Singh
Thomas Jefferson University, Philadelphia, PA
*Purpose: Live kidney donation can be an overwhelming process even for the highly motivated individuals. Live donors may have to spend up to $5000 for…